Global Emergence of Resistance to Fluconazole and Voriconazole in Candida parapsilosis in Tertiary Hospitals in Spain During the OVID-19 Pandemic

Candida parapsilosis is a frequent cause of candidemia worldwide. Its incidence is associated with the use of medical implants, such as central venous catheters or parenteral nutrition. This species has reduced susceptibility to echinocandins, and it is susceptible to polyenes and azoles. Multiple o...

Descripción completa

Detalles Bibliográficos
Autores: Trevijano-Contador, Nuria, Torres-Cano, Alba, Carballo-González, Cristina, Puig-Asensio, Mireia|||0000-0002-0722-2218, Martin-Gomez, M. Teresa|||0000-0001-8119-8749, Jiménez-Martínez, Emilio|||0000-0003-2831-037X, Romero, Daniel|||0000-0003-4934-2477, Nuvials, Xavier|||0000-0002-6648-2394, Olmos-Arenas, Roberto, Moretó-Castellsagué, María Clara, Fernández-Delgado, Lucía|||0000-0001-8815-0967, Rodríguez-Sevilla, Graciela, Aguilar-Sánchez, María-Mercedes, Ayats, Josefina, Ardanuy, Carmen|||0000-0003-0225-607X, Sánchez Romero, María Isabel, Muñoz-Algarra, María, Merino-Amador, Paloma, González-Romo, Fernando, Megías-Lobón, Gregoria, García-Campos, Jose Angel, Mantecón-Vallejo, María Ángeles, Alcoceba, Eva, Escribano Martos, Pilar|||0000-0001-6254-4570, Guinea, Jesús, Durán-Valle, Maria Teresa, Fraile-Torres, Arturo, Roiz-Mesones, María Pía, Lara-Plaza, Isabel, de Ayala, Ana Pérez, Simón-Sacristán, María, Collazos-Blanco, Ana, Nebreda-Mayoral, Teresa, March-Roselló, Gabriel, Alcázar-Fuoli, Laura, Zaragoza, Óscar|||0000-0002-1581-0845
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:269566
Acceso en línea:https://ddd.uab.cat/record/269566
https://dx.doi.org/urn:doi:10.1093/ofid/ofac605
Access Level:acceso abierto
Palabra clave:Candida parapsilosis
Antifungal resistance
Fluconazole
Outbreaks
Voriconazole
Descripción
Sumario:Candida parapsilosis is a frequent cause of candidemia worldwide. Its incidence is associated with the use of medical implants, such as central venous catheters or parenteral nutrition. This species has reduced susceptibility to echinocandins, and it is susceptible to polyenes and azoles. Multiple outbreaks caused by fluconazole-nonsusceptible strains have been reported recently. A similar trend has been observed among the C. parapsilosis isolates received in the last 2 years at the Spanish Mycology Reference Laboratory. Yeast were identified by molecular biology, and antifungal susceptibility testing was performed using the European Committee on Antimicrobial Susceptibility Testing protocol. The ERG11 gene was sequenced to identify resistance mechanisms, and strain typing was carried out by microsatellite analysis. We examined the susceptibility profile of 1315 C. parapsilosis isolates available at our reference laboratory between 2000 and 2021, noticing an increase in the number of isolates with acquired resistance to fluconazole, and voriconazole has increased in at least 8 different Spanish hospitals in 2020-2021. From 121 recorded clones, 3 were identified as the most prevalent in Spain (clone 10 in Catalonia and clone 96 in Castilla-Leon and Madrid, whereas clone 67 was found in 2 geographically unrelated regions, Cantabria and the Balearic Islands). Our data suggest that concurrently with the coronavirus disease 2019 pandemic, a selection of fluconazole-resistant C. parapsilosis isolates has occurred in Spain, and the expansion of specific clones has been noted across centers. Further research is needed to determine the factors that underlie the successful expansion of these clones and their potential genetic relatedness.

Similares en LA Referencia