Prospective association between plasma amino acids and healthy aging in older adults
Background. Most studies have compared plasma amino acids profiling across different age groups using a cross-sectional design, but no previous research has assessed the relationship between specific amino acid species and healthy aging. Objectives. This study aims to explore the relationship between...
| Autores: | , , , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/720405 |
| Acesso em linha: | http://hdl.handle.net/10486/720405 https://dx.doi.org/10.1111/joim.20105 |
| Access Level: | acceso abierto |
| Palavra-chave: | amino acids healthy aging lifestyle behaviors metabolomic profiling older adults Medicina |
| Resumo: | Background. Most studies have compared plasma amino acids profiling across different age groups using a cross-sectional design, but no previous research has assessed the relationship between specific amino acid species and healthy aging. Objectives. This study aims to explore the relationship between plasma concentrations of nine amino acids and healthy aging in an older Spanish population. Methods. This longitudinal study uses data from the Seniors-ENRICA 2 Spanish cohort, which comprises community-dwelling individuals aged65 and older. Plasma amino acid concentrations were measured at baseline and after a 5-year follow-up period (n = 859). Healthy aging has been defined as the delay on the onset of chronic conditions, optimal physical functioning, and no cognitive impairment. Multilevel mixed effect logistic models were used to examine the prospective association proposed, after adjusting for age, sex, socioeconomic status, and lifestyle. Results. The baseline mean age of the participants was 70.9 years (standard deviation [SD] = 4.0), and 51.6% were men. In the fully adjusted models, lower plasma concentrations of alanine [odds ratios per 1-SD increase (95% confidence interval) = 0.78 (0.72, 0.86)], isoleucine [0.70 (0.63,0.78)], leucine [0.78 (0.71, 0.86)], and valine [0.79(0.71, 0.86)] were prospectively associated with healthy aging (p-value < 0.001 in all cases). No significant associations were observed for glutamine, glycine, histidine, and aromatic aminoacids. Conclusion. Lower concentrations of alanine and branched-chain amino acids were prospectively associated with healthy aging in the older population |
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