Physiological relevance of cell division regulators in mammalian neural development

A cubic millimeter of the cerebral cortex in the adult human brain may contain a hundred thousand cells, interacting by billions of synapses, and operating with a precision scale of milliseconds. Such cognitive dexterity allows our brain to extract, process, code, store and interpret an overwhelming...

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Detalles Bibliográficos
Autor: González Martín, José
Tipo de recurso: tesis doctoral
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/91581
Acceso en línea:https://hdl.handle.net/20.500.14352/91581
Access Level:acceso abierto
Palabra clave:611.813.1(043.2)
Cortex cerebral
Cerebral Cortex
Neurociencias (Medicina)
3205.07 Neurología
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spelling Physiological relevance of cell division regulators in mammalian neural developmentRelevancia fisiológica de los reguladores de la división celular en el desarrollo neural de mamíferosGonzález Martín, José611.813.1(043.2)Cortex cerebralCerebral CortexNeurociencias (Medicina)3205.07 NeurologíaA cubic millimeter of the cerebral cortex in the adult human brain may contain a hundred thousand cells, interacting by billions of synapses, and operating with a precision scale of milliseconds. Such cognitive dexterity allows our brain to extract, process, code, store and interpret an overwhelming amount of information about the environment and our own internal states. The brain can be considered a critical mediator for all cognitive processes including perception, motivation, memory, learning or emotion among others. Following the ontogenetic theory, a possibility to unwire the highly intricate complexity of the brain anatomy and function, entails a deep understanding of its own development. Development of the cerebral cortex in mammals relies on the tight regulation of the proliferation and differentiation of neural progenitor cells (NPs). Whereas neuroepithelial cells (NECs) initially constitute the neural tube, a hierarchy of differentially-fated NPs stems from them. NPs are able to differentiate towards the neural, astrocytic and oligodendrocytic cell lineages which populate the adult brain, and interact together forming neural networks, key for correct brain functioning. However, the molecular and cellular mechanisms underlying NPs diversity and behavior are still far from clear. Whereas cell division is known to be a critical event for the proliferation and expansion of NPs, is also proposed to be in the root of the process of cell fate and lineage diversity acquisition during neurodevelopment...Universidad Complutense de MadridMalumbres Martínez, MarcosUniversidad Complutense de Madrid20232023-12-2020232023-12-20doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/91581reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/915812026-06-02T12:44:21Z
dc.title.none.fl_str_mv Physiological relevance of cell division regulators in mammalian neural development
Relevancia fisiológica de los reguladores de la división celular en el desarrollo neural de mamíferos
title Physiological relevance of cell division regulators in mammalian neural development
spellingShingle Physiological relevance of cell division regulators in mammalian neural development
González Martín, José
611.813.1(043.2)
Cortex cerebral
Cerebral Cortex
Neurociencias (Medicina)
3205.07 Neurología
title_short Physiological relevance of cell division regulators in mammalian neural development
title_full Physiological relevance of cell division regulators in mammalian neural development
title_fullStr Physiological relevance of cell division regulators in mammalian neural development
title_full_unstemmed Physiological relevance of cell division regulators in mammalian neural development
title_sort Physiological relevance of cell division regulators in mammalian neural development
dc.creator.none.fl_str_mv González Martín, José
author González Martín, José
author_facet González Martín, José
author_role author
dc.contributor.none.fl_str_mv Malumbres Martínez, Marcos
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 611.813.1(043.2)
Cortex cerebral
Cerebral Cortex
Neurociencias (Medicina)
3205.07 Neurología
topic 611.813.1(043.2)
Cortex cerebral
Cerebral Cortex
Neurociencias (Medicina)
3205.07 Neurología
description A cubic millimeter of the cerebral cortex in the adult human brain may contain a hundred thousand cells, interacting by billions of synapses, and operating with a precision scale of milliseconds. Such cognitive dexterity allows our brain to extract, process, code, store and interpret an overwhelming amount of information about the environment and our own internal states. The brain can be considered a critical mediator for all cognitive processes including perception, motivation, memory, learning or emotion among others. Following the ontogenetic theory, a possibility to unwire the highly intricate complexity of the brain anatomy and function, entails a deep understanding of its own development. Development of the cerebral cortex in mammals relies on the tight regulation of the proliferation and differentiation of neural progenitor cells (NPs). Whereas neuroepithelial cells (NECs) initially constitute the neural tube, a hierarchy of differentially-fated NPs stems from them. NPs are able to differentiate towards the neural, astrocytic and oligodendrocytic cell lineages which populate the adult brain, and interact together forming neural networks, key for correct brain functioning. However, the molecular and cellular mechanisms underlying NPs diversity and behavior are still far from clear. Whereas cell division is known to be a critical event for the proliferation and expansion of NPs, is also proposed to be in the root of the process of cell fate and lineage diversity acquisition during neurodevelopment...
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-12-20
2023
2023-12-20
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/91581
url https://hdl.handle.net/20.500.14352/91581
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
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dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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