Membrane curvature induces cardiolipin sorting

Cardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of bacteria and in the mitochondrial cristae. This specific localization has been argued to be geometry-driven, since the CL’s conical shape relaxes curvature frustration. Although previous evidence suggests a coupli...

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Detalles Bibliográficos
Autores: Beltrán De Heredia Rodríguez, Elena, Tsai, Feng-Ching, Salinas-Almaguer, Samuel, Cao García, Francisco Javier, Bassereau, Patricia, Monroy, Francisco
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/104514
Acceso en línea:https://hdl.handle.net/20.500.14352/104514
Access Level:acceso abierto
Palabra clave:576
Biología celular (Biología)
2407 Biología Celular
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spelling Membrane curvature induces cardiolipin sortingBeltrán De Heredia Rodríguez, ElenaTsai, Feng-ChingSalinas-Almaguer, SamuelCao García, Francisco JavierBassereau, PatriciaMonroy, Francisco576Biología celular (Biología)2407 Biología CelularCardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of bacteria and in the mitochondrial cristae. This specific localization has been argued to be geometry-driven, since the CL’s conical shape relaxes curvature frustration. Although previous evidence suggests a coupling between CL concentration and membrane shape in vivo, no precise experimental data are available for curvature-based CL sorting in vitro. Here, we test this hypothesis in experiments that isolate the effects of membrane curvature in lipidbilayer nanotubes. CL sorting is observed with increasing tube curvature, reaching a maximum at optimal CL concentrations, a fact compatible with self-associative clustering. Observations are compatible with a model of membrane elasticity including van der Waals entropy, from which a negative intrinsic curvature of −1.1 nm−1 is predicted for CL. The results contribute to understanding the physicochemical interplay between membrane curvature and composition, providing key insights into mitochondrial and bacterial membrane organization and dynamics.Nature ResearchUniversidad Complutense de Madrid20192019-06-2020192019-06-20journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/104514reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengMinisterio de Educación, Cultura y Deporte http://dx.doi.org/10.13039/501100003176 Not available FPU2013%2F02826 FPU2013%2F02826Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available FIS2015-70339-C2-1-R MATERIA ACTIVA ACCIONADA MEDIANTE POLIMEROS VIVOS BIOLOGICOS: DE LA ESTOCASTICIDAD MICROSCOPICA A LA MECANICA MACROSCOPICA A TRAVES DE LA HIDRODINAMICAMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available FIS2015-67745-R MECANICA, ENERGETICA Y DINAMICA DE FLUCTUACIONES DE LA REPLICACION DEL ADN MITOCONDRIALopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1045142026-06-02T12:44:21Z
dc.title.none.fl_str_mv Membrane curvature induces cardiolipin sorting
title Membrane curvature induces cardiolipin sorting
spellingShingle Membrane curvature induces cardiolipin sorting
Beltrán De Heredia Rodríguez, Elena
576
Biología celular (Biología)
2407 Biología Celular
title_short Membrane curvature induces cardiolipin sorting
title_full Membrane curvature induces cardiolipin sorting
title_fullStr Membrane curvature induces cardiolipin sorting
title_full_unstemmed Membrane curvature induces cardiolipin sorting
title_sort Membrane curvature induces cardiolipin sorting
dc.creator.none.fl_str_mv Beltrán De Heredia Rodríguez, Elena
Tsai, Feng-Ching
Salinas-Almaguer, Samuel
Cao García, Francisco Javier
Bassereau, Patricia
Monroy, Francisco
author Beltrán De Heredia Rodríguez, Elena
author_facet Beltrán De Heredia Rodríguez, Elena
Tsai, Feng-Ching
Salinas-Almaguer, Samuel
Cao García, Francisco Javier
Bassereau, Patricia
Monroy, Francisco
author_role author
author2 Tsai, Feng-Ching
Salinas-Almaguer, Samuel
Cao García, Francisco Javier
Bassereau, Patricia
Monroy, Francisco
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 576
Biología celular (Biología)
2407 Biología Celular
topic 576
Biología celular (Biología)
2407 Biología Celular
description Cardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of bacteria and in the mitochondrial cristae. This specific localization has been argued to be geometry-driven, since the CL’s conical shape relaxes curvature frustration. Although previous evidence suggests a coupling between CL concentration and membrane shape in vivo, no precise experimental data are available for curvature-based CL sorting in vitro. Here, we test this hypothesis in experiments that isolate the effects of membrane curvature in lipidbilayer nanotubes. CL sorting is observed with increasing tube curvature, reaching a maximum at optimal CL concentrations, a fact compatible with self-associative clustering. Observations are compatible with a model of membrane elasticity including van der Waals entropy, from which a negative intrinsic curvature of −1.1 nm−1 is predicted for CL. The results contribute to understanding the physicochemical interplay between membrane curvature and composition, providing key insights into mitochondrial and bacterial membrane organization and dynamics.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-06-20
2019
2019-06-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/104514
url https://hdl.handle.net/20.500.14352/104514
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Educación, Cultura y Deporte http://dx.doi.org/10.13039/501100003176 Not available FPU2013%2F02826 FPU2013%2F02826
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available FIS2015-70339-C2-1-R MATERIA ACTIVA ACCIONADA MEDIANTE POLIMEROS VIVOS BIOLOGICOS: DE LA ESTOCASTICIDAD MICROSCOPICA A LA MECANICA MACROSCOPICA A TRAVES DE LA HIDRODINAMICA
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Not available FIS2015-67745-R MECANICA, ENERGETICA Y DINAMICA DE FLUCTUACIONES DE LA REPLICACION DEL ADN MITOCONDRIAL
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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