Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia

Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive p...

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Autores: Cillóniz, Catia, Dominedò, Cristina, Ielpo, Antonella, Ferrer Monreal, Miquel, Gabarrús, Albert, Battaglini, Denise, Bermejo Martín, Jesús, Meli, Andrea, Garcia Vidal, Carolina, Liapikou, Adamantia, Singer, Mervyn, Torres Martí, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/145319
Acceso en línea:https://hdl.handle.net/2445/145319
Access Level:acceso abierto
Palabra clave:Pneumònia adquirida a la comunitat
Septicèmia
Persones grans
Community-acquired pneumonia
Septicemia
Older people
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spelling Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired PneumoniaCillóniz, CatiaDominedò, CristinaIelpo, AntonellaFerrer Monreal, MiquelGabarrús, AlbertBattaglini, DeniseBermejo Martín, JesúsMeli, AndreaGarcia Vidal, CarolinaLiapikou, AdamantiaSinger, MervynTorres Martí, AntoniPneumònia adquirida a la comunitatSepticèmiaPersones gransCommunity-acquired pneumoniaSepticemiaOlder peopleLittle is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive patients hospitalized with CAP were included if they were very old (≥80 years) and divided into those with and without sepsis for comparison. Sepsis was diagnosed based on the Sepsis-3 criteria. The main clinical outcome was 30-day mortality. Results: Among the 4219 patients hospitalized with CAP during the study period, 1238 (29%) were very old. The prevalence of sepsis in this age group was 71%. Male sex, chronic renal disease, and diabetes mellitus were independent risk factors for sepsis, while antibiotic therapy before admission was independently associated with a lower risk of sepsis. Thirty-day and intensive care unit (ICU) mortality did not differ between patients with and without sepsis. In CAP-sepsis group, chronic renal disease and neurological disease were independent risk factors for 30-day mortality. Conclusion: In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis.MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/145319Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jcm8070961Journal of Clinical Medicine, 2019, vol. 8, num. 7https://doi.org/10.3390/jcm8070961cc by (c) Cillóniz et al., 2019http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1453192026-05-27T06:46:51Z
dc.title.none.fl_str_mv Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
title Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
spellingShingle Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
Cillóniz, Catia
Pneumònia adquirida a la comunitat
Septicèmia
Persones grans
Community-acquired pneumonia
Septicemia
Older people
title_short Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
title_full Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
title_fullStr Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
title_full_unstemmed Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
title_sort Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
dc.creator.none.fl_str_mv Cillóniz, Catia
Dominedò, Cristina
Ielpo, Antonella
Ferrer Monreal, Miquel
Gabarrús, Albert
Battaglini, Denise
Bermejo Martín, Jesús
Meli, Andrea
Garcia Vidal, Carolina
Liapikou, Adamantia
Singer, Mervyn
Torres Martí, Antoni
author Cillóniz, Catia
author_facet Cillóniz, Catia
Dominedò, Cristina
Ielpo, Antonella
Ferrer Monreal, Miquel
Gabarrús, Albert
Battaglini, Denise
Bermejo Martín, Jesús
Meli, Andrea
Garcia Vidal, Carolina
Liapikou, Adamantia
Singer, Mervyn
Torres Martí, Antoni
author_role author
author2 Dominedò, Cristina
Ielpo, Antonella
Ferrer Monreal, Miquel
Gabarrús, Albert
Battaglini, Denise
Bermejo Martín, Jesús
Meli, Andrea
Garcia Vidal, Carolina
Liapikou, Adamantia
Singer, Mervyn
Torres Martí, Antoni
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pneumònia adquirida a la comunitat
Septicèmia
Persones grans
Community-acquired pneumonia
Septicemia
Older people
topic Pneumònia adquirida a la comunitat
Septicèmia
Persones grans
Community-acquired pneumonia
Septicemia
Older people
description Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive patients hospitalized with CAP were included if they were very old (≥80 years) and divided into those with and without sepsis for comparison. Sepsis was diagnosed based on the Sepsis-3 criteria. The main clinical outcome was 30-day mortality. Results: Among the 4219 patients hospitalized with CAP during the study period, 1238 (29%) were very old. The prevalence of sepsis in this age group was 71%. Male sex, chronic renal disease, and diabetes mellitus were independent risk factors for sepsis, while antibiotic therapy before admission was independently associated with a lower risk of sepsis. Thirty-day and intensive care unit (ICU) mortality did not differ between patients with and without sepsis. In CAP-sepsis group, chronic renal disease and neurological disease were independent risk factors for 30-day mortality. Conclusion: In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/145319
url https://hdl.handle.net/2445/145319
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm8070961
Journal of Clinical Medicine, 2019, vol. 8, num. 7
https://doi.org/10.3390/jcm8070961
dc.rights.none.fl_str_mv cc by (c) Cillóniz et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Cillóniz et al., 2019
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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