Engineering and monitoring cellular barrier models

Epithelia and endothelia delineate tissue compartments and control their environments by regulating the passage of ions and solutes. This barrier function is essential for the development and maintenance of multicellular organisms, and its dysfunction is associated with numerous human diseases. Rece...

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Detalles Bibliográficos
Autores: Yeste Lozano, José, Illa, Xavi, Álvarez, Mar, Villa, Rosa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/169752
Acceso en línea:http://hdl.handle.net/10261/169752
Access Level:acceso abierto
Palabra clave:Biological barriers
Cell barrier function
Microphysiological systems
Transepithelial electrical properties
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spelling Engineering and monitoring cellular barrier modelsYeste Lozano, JoséIlla, XaviÁlvarez, MarVilla, RosaBiological barriersCell barrier functionMicrophysiological systemsTransepithelial electrical propertiesEpithelia and endothelia delineate tissue compartments and control their environments by regulating the passage of ions and solutes. This barrier function is essential for the development and maintenance of multicellular organisms, and its dysfunction is associated with numerous human diseases. Recent advances in biomaterials and microfabrication technologies have evolved in vitro approaches for modelling biological barriers. Current microphysiological systems have become more efficient and reliable in mimicking the cell microenvironment. Additionally, methods for the quantification of barrier permeability have long provided significant insight into their underlying mechanisms. In this review, we outline the current techniques to quantify the barrier function of engineered tissues, and we also give an overview of recent microphysiological systems of biological barriers that emulate the microenvironment and microarchitecture of native tissues.This work has been supported by grants from the Ministerio de Economía y Competitividad (MINECO) (SAF2014–62114-EXP, DPI2015–65401-C3–3-R, and RYC-2013-14479) and from CIBER in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN).Peer reviewedBioMed CentralMinisterio de Economía y Competitividad (España)Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820182018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/169752reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-62114-EXPinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/DPI2015-65401-C3-3-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-14479https://doi.org/10.1186/s13036-018-0108-5Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1697522026-05-22T06:33:51Z
dc.title.none.fl_str_mv Engineering and monitoring cellular barrier models
title Engineering and monitoring cellular barrier models
spellingShingle Engineering and monitoring cellular barrier models
Yeste Lozano, José
Biological barriers
Cell barrier function
Microphysiological systems
Transepithelial electrical properties
title_short Engineering and monitoring cellular barrier models
title_full Engineering and monitoring cellular barrier models
title_fullStr Engineering and monitoring cellular barrier models
title_full_unstemmed Engineering and monitoring cellular barrier models
title_sort Engineering and monitoring cellular barrier models
dc.creator.none.fl_str_mv Yeste Lozano, José
Illa, Xavi
Álvarez, Mar
Villa, Rosa
author Yeste Lozano, José
author_facet Yeste Lozano, José
Illa, Xavi
Álvarez, Mar
Villa, Rosa
author_role author
author2 Illa, Xavi
Álvarez, Mar
Villa, Rosa
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Biological barriers
Cell barrier function
Microphysiological systems
Transepithelial electrical properties
topic Biological barriers
Cell barrier function
Microphysiological systems
Transepithelial electrical properties
description Epithelia and endothelia delineate tissue compartments and control their environments by regulating the passage of ions and solutes. This barrier function is essential for the development and maintenance of multicellular organisms, and its dysfunction is associated with numerous human diseases. Recent advances in biomaterials and microfabrication technologies have evolved in vitro approaches for modelling biological barriers. Current microphysiological systems have become more efficient and reliable in mimicking the cell microenvironment. Additionally, methods for the quantification of barrier permeability have long provided significant insight into their underlying mechanisms. In this review, we outline the current techniques to quantify the barrier function of engineered tissues, and we also give an overview of recent microphysiological systems of biological barriers that emulate the microenvironment and microarchitecture of native tissues.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/169752
url http://hdl.handle.net/10261/169752
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-62114-EXP
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/DPI2015-65401-C3-3-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-14479
https://doi.org/10.1186/s13036-018-0108-5
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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