Neuropsychological deficits in patients with cognitive complaints after COVID-19
Background: While much of the scientific focus thus far has been on cognitive sequelae in patients with severe COVID-19, subjective cognitive complaints are being reported across the spectrum of disease severity, with recent studies beginning to corroborate patients' perceived deficits. In resp...
| Autores: | , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:280884 |
| Acceso en línea: | https://ddd.uab.cat/record/280884 https://dx.doi.org/urn:doi:10.1002/brb3.2508 |
| Access Level: | acceso abierto |
| Palabra clave: | Cognition Cognitive complaints Neuropsychology Post-COVID-19 |
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Neuropsychological deficits in patients with cognitive complaints after COVID-19García Sánchez, Carmen|||0000-0001-5672-9229Calabria, Marco|||0000-0003-4373-1316Grunden, Nicholas|||0000-0002-7724-4316Pons, CatalinaArroyo Díaz, Juan Antonio|||0000-0001-8029-7374Gómez Ansón, Beatriz|||0000-0001-7900-938XLleó, Alberto|||0000-0002-2568-5478Alcolea, Daniel|||0000-0002-3819-3245Belvís, Roberto|||0000-0002-2137-180XMorollón Sánchez-Mateos, Noemí|||0000-0003-4256-4210Mur, Isabel|||0000-0001-7660-8483Pomar, Virginia|||0000-0002-8473-5834Domingo Pedrol, Pedro|||0000-0003-1138-5770CognitionCognitive complaintsNeuropsychologyPost-COVID-19Background: While much of the scientific focus thus far has been on cognitive sequelae in patients with severe COVID-19, subjective cognitive complaints are being reported across the spectrum of disease severity, with recent studies beginning to corroborate patients' perceived deficits. In response to this, the aims of this study were to (1) explore the frequency of impaired performance across cognitive domains in post-COVID patients with subjective complaints and (2) uncover whether impairment existed within a single domain or across multiple. Methods: Sixty-three patients with subjective cognitive complaints post-COVID were assessed with a comprehensive protocol consisting of various neuropsychological tests and mood measures. Cognitive test performance was transformed into T scores and classified based on recommended guidelines. After performing a principal component analysis to define cognitive domain factors, distributions of test scores within and across domains were analyzed. Results: Results revealed pervasive impact on attention abilities, both as the singularly affected domain (19% of single-domain impairment) as well as coupled with decreased performance in executive functions, learning, and long-term memory. These salient attentional and associated executive deficits were largely unrelated to clinical factors such as hospitalization, disease duration, biomarkers, or affective measures. Discussion: These findings stress the importance of comprehensive evaluation and intervention to address cognitive sequelae in post-COVID patients of varying disease courses, not just those who were hospitalized or experienced severe symptoms. Future studies should investigate to what extent these cognitive abilities are recuperated over time as well as employ neuroimaging techniques to uncover underlying mechanisms of neural damage. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/280884https://dx.doi.org/urn:doi:10.1002/brb3.2508reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2808842026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Neuropsychological deficits in patients with cognitive complaints after COVID-19 |
| title |
Neuropsychological deficits in patients with cognitive complaints after COVID-19 |
| spellingShingle |
Neuropsychological deficits in patients with cognitive complaints after COVID-19 García Sánchez, Carmen|||0000-0001-5672-9229 Cognition Cognitive complaints Neuropsychology Post-COVID-19 |
| title_short |
Neuropsychological deficits in patients with cognitive complaints after COVID-19 |
| title_full |
Neuropsychological deficits in patients with cognitive complaints after COVID-19 |
| title_fullStr |
Neuropsychological deficits in patients with cognitive complaints after COVID-19 |
| title_full_unstemmed |
Neuropsychological deficits in patients with cognitive complaints after COVID-19 |
| title_sort |
Neuropsychological deficits in patients with cognitive complaints after COVID-19 |
| dc.creator.none.fl_str_mv |
García Sánchez, Carmen|||0000-0001-5672-9229 Calabria, Marco|||0000-0003-4373-1316 Grunden, Nicholas|||0000-0002-7724-4316 Pons, Catalina Arroyo Díaz, Juan Antonio|||0000-0001-8029-7374 Gómez Ansón, Beatriz|||0000-0001-7900-938X Lleó, Alberto|||0000-0002-2568-5478 Alcolea, Daniel|||0000-0002-3819-3245 Belvís, Roberto|||0000-0002-2137-180X Morollón Sánchez-Mateos, Noemí|||0000-0003-4256-4210 Mur, Isabel|||0000-0001-7660-8483 Pomar, Virginia|||0000-0002-8473-5834 Domingo Pedrol, Pedro|||0000-0003-1138-5770 |
| author |
García Sánchez, Carmen|||0000-0001-5672-9229 |
| author_facet |
García Sánchez, Carmen|||0000-0001-5672-9229 Calabria, Marco|||0000-0003-4373-1316 Grunden, Nicholas|||0000-0002-7724-4316 Pons, Catalina Arroyo Díaz, Juan Antonio|||0000-0001-8029-7374 Gómez Ansón, Beatriz|||0000-0001-7900-938X Lleó, Alberto|||0000-0002-2568-5478 Alcolea, Daniel|||0000-0002-3819-3245 Belvís, Roberto|||0000-0002-2137-180X Morollón Sánchez-Mateos, Noemí|||0000-0003-4256-4210 Mur, Isabel|||0000-0001-7660-8483 Pomar, Virginia|||0000-0002-8473-5834 Domingo Pedrol, Pedro|||0000-0003-1138-5770 |
| author_role |
author |
| author2 |
Calabria, Marco|||0000-0003-4373-1316 Grunden, Nicholas|||0000-0002-7724-4316 Pons, Catalina Arroyo Díaz, Juan Antonio|||0000-0001-8029-7374 Gómez Ansón, Beatriz|||0000-0001-7900-938X Lleó, Alberto|||0000-0002-2568-5478 Alcolea, Daniel|||0000-0002-3819-3245 Belvís, Roberto|||0000-0002-2137-180X Morollón Sánchez-Mateos, Noemí|||0000-0003-4256-4210 Mur, Isabel|||0000-0001-7660-8483 Pomar, Virginia|||0000-0002-8473-5834 Domingo Pedrol, Pedro|||0000-0003-1138-5770 |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cognition Cognitive complaints Neuropsychology Post-COVID-19 |
| topic |
Cognition Cognitive complaints Neuropsychology Post-COVID-19 |
| description |
Background: While much of the scientific focus thus far has been on cognitive sequelae in patients with severe COVID-19, subjective cognitive complaints are being reported across the spectrum of disease severity, with recent studies beginning to corroborate patients' perceived deficits. In response to this, the aims of this study were to (1) explore the frequency of impaired performance across cognitive domains in post-COVID patients with subjective complaints and (2) uncover whether impairment existed within a single domain or across multiple. Methods: Sixty-three patients with subjective cognitive complaints post-COVID were assessed with a comprehensive protocol consisting of various neuropsychological tests and mood measures. Cognitive test performance was transformed into T scores and classified based on recommended guidelines. After performing a principal component analysis to define cognitive domain factors, distributions of test scores within and across domains were analyzed. Results: Results revealed pervasive impact on attention abilities, both as the singularly affected domain (19% of single-domain impairment) as well as coupled with decreased performance in executive functions, learning, and long-term memory. These salient attentional and associated executive deficits were largely unrelated to clinical factors such as hospitalization, disease duration, biomarkers, or affective measures. Discussion: These findings stress the importance of comprehensive evaluation and intervention to address cognitive sequelae in post-COVID patients of varying disease courses, not just those who were hospitalized or experienced severe symptoms. Future studies should investigate to what extent these cognitive abilities are recuperated over time as well as employ neuroimaging techniques to uncover underlying mechanisms of neural damage. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/280884 https://dx.doi.org/urn:doi:10.1002/brb3.2508 |
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https://ddd.uab.cat/record/280884 https://dx.doi.org/urn:doi:10.1002/brb3.2508 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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