Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry

9 páginas, 2 figuras, 1 tabla

Detalles Bibliográficos
Autores: González Miguel, Javier, Morchón, Rodrigo, Siles Lucas, Mar, Oleaga, Ana, Simón Martín, Fernando
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2010
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/345111
Acceso en línea:http://hdl.handle.net/10261/345111
https://api.elsevier.com/content/abstract/scopus_id/77955842447
Access Level:acceso abierto
Palabra clave:Antigens
Dirofilaria immitis
Cats
Mass spectrometry
Soluble proteome
antigens
cats
mass spectrometry
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spelling Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometryGonzález Miguel, JavierMorchón, RodrigoSiles Lucas, MarOleaga, AnaSimón Martín, FernandoAntigensDirofilaria immitisCatsMass spectrometrySoluble proteomeantigenscatsDirofilaria immitismass spectrometry9 páginas, 2 figuras, 1 tablaThe aim of the present work was to identify proteins of Dirofilaria immitis recognized by the immune system of naturally and experimentally infected cats, using two-dimensional electrophoresis and mass spectrometry. Thirty-five immunoreactive proteins of D. immitis were identified. These proteins are involved in metabolism, plasminogen binding, anti-oxidant and detoxificant activity, up-regulation of the Th2 anti-inflammatory response and other processes. The timing evolution of this recognition pattern indicated that at 2 months post-infection a wide recognition of many parasite proteins belonging to many functional groups is still observed, increasing progressively during the course of the infection. The real effect on the vital capacity of D. immitis worms and on the development of pathological events of feline dirofilariosis will be investigated in the future.This research was supported by Agencia de Desarrollo Económico de Castilla y León (grant SA090/A09), Spain.Peer reviewedElsevierJunta de Castilla y LeónGonzález Miguel, Javier [0000-0003-4279-4761]Siles Lucas, Mar [0000-0002-1257-2562]Oleaga, Ana [0000-0002-8019-7354]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/345111https://api.elsevier.com/content/abstract/scopus_id/77955842447reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésMolecular and biochemical parasitologyhttp://dx.doi.org/10.1016/j.molbiopara.2010.06.013Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3451112026-05-22T06:33:51Z
dc.title.none.fl_str_mv Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry
title Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry
spellingShingle Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry
González Miguel, Javier
Antigens
Dirofilaria immitis
Cats
Mass spectrometry
Soluble proteome
antigens
cats
Dirofilaria immitis
mass spectrometry
title_short Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry
title_full Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry
title_fullStr Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry
title_full_unstemmed Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry
title_sort Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry
dc.creator.none.fl_str_mv González Miguel, Javier
Morchón, Rodrigo
Siles Lucas, Mar
Oleaga, Ana
Simón Martín, Fernando
author González Miguel, Javier
author_facet González Miguel, Javier
Morchón, Rodrigo
Siles Lucas, Mar
Oleaga, Ana
Simón Martín, Fernando
author_role author
author2 Morchón, Rodrigo
Siles Lucas, Mar
Oleaga, Ana
Simón Martín, Fernando
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Junta de Castilla y León
González Miguel, Javier [0000-0003-4279-4761]
Siles Lucas, Mar [0000-0002-1257-2562]
Oleaga, Ana [0000-0002-8019-7354]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Antigens
Dirofilaria immitis
Cats
Mass spectrometry
Soluble proteome
antigens
cats
Dirofilaria immitis
mass spectrometry
topic Antigens
Dirofilaria immitis
Cats
Mass spectrometry
Soluble proteome
antigens
cats
Dirofilaria immitis
mass spectrometry
description 9 páginas, 2 figuras, 1 tabla
publishDate 2010
dc.date.none.fl_str_mv 2010
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/345111
https://api.elsevier.com/content/abstract/scopus_id/77955842447
url http://hdl.handle.net/10261/345111
https://api.elsevier.com/content/abstract/scopus_id/77955842447
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Molecular and biochemical parasitology
http://dx.doi.org/10.1016/j.molbiopara.2010.06.013
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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