An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis

The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mit...

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Detalhes bibliográficos
Autores: Meunier, Sylvain, Shvedunova, Maria, Van Nguyen, Nhuong, Ávila, Leonor, Vernos, Isabelle, 1959-, Akhtar, Asifa
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2015
País:España
Recursos:Universitat Pompeu Fabra
Repositório:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/25113
Acesso em linha:http://hdl.handle.net/10230/25113
http://dx.doi.org/10.1038/ncomms8889
Access Level:Acceso aberto
Palavra-chave:Regulació genètica
Mitosi
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spelling An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosisMeunier, SylvainShvedunova, MariaVan Nguyen, NhuongÁvila, LeonorVernos, Isabelle, 1959-Akhtar, AsifaRegulació genèticaMitosiThe evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle.Nature Publishing Group201520152015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25113http://dx.doi.org/10.1038/ncomms8889reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNature communications. 2015;6:7889© 2015 Macmillan Publishers Limited. All rights reserved. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/251132026-06-12T07:21:37Z
dc.title.none.fl_str_mv An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
spellingShingle An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
Meunier, Sylvain
Regulació genètica
Mitosi
title_short An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title_full An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title_fullStr An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title_full_unstemmed An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title_sort An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
dc.creator.none.fl_str_mv Meunier, Sylvain
Shvedunova, Maria
Van Nguyen, Nhuong
Ávila, Leonor
Vernos, Isabelle, 1959-
Akhtar, Asifa
author Meunier, Sylvain
author_facet Meunier, Sylvain
Shvedunova, Maria
Van Nguyen, Nhuong
Ávila, Leonor
Vernos, Isabelle, 1959-
Akhtar, Asifa
author_role author
author2 Shvedunova, Maria
Van Nguyen, Nhuong
Ávila, Leonor
Vernos, Isabelle, 1959-
Akhtar, Asifa
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Regulació genètica
Mitosi
topic Regulació genètica
Mitosi
description The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/25113
http://dx.doi.org/10.1038/ncomms8889
url http://hdl.handle.net/10230/25113
http://dx.doi.org/10.1038/ncomms8889
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nature communications. 2015;6:7889
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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