F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse

The adaptive immune response depends on the interaction of T cells and antigen-presenting cells at the immune synapse. Formation of the immune synapse and the subsequent T-cell activation are highly dependent on the actin cytoskeleton. In this work, we describe that T cells express drebrin, a neuron...

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Autores: Pérez-Martínez, Manuel, Gordón-Alonso, Mónica, Román Cabrero, José, Barrero-Villar, Marta, Rey, Mercedes, Mittelbrunn, María, Lamana Domínguez, Amalia, Morlino, Giulia, Calabia, Carmen, Yamazaki, Hiroyuki, Shirao, Tomoaki, Vázquez, Jesús, González-Amaro, Roberto, Veiga, Esteban, Sánchez-Madrid, Francisco
Tipo de recurso: artículo
Fecha de publicación:2010
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/96255
Acceso en línea:https://hdl.handle.net/20.500.14352/96255
Access Level:acceso abierto
Palabra clave:576
577.1
Actin cytoskeleton
CXCR4
Immune synapse
Biología celular (Biología)
Bioquímica (Biología)
2407 Biología Celular
2403 Bioquímica
id ES_e3ba51facf778bcca41d2c66a7b643d4
oai_identifier_str oai:docta.ucm.es:20.500.14352/96255
network_acronym_str ES
network_name_str España
repository_id_str
spelling F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapsePérez-Martínez, ManuelGordón-Alonso, MónicaRomán Cabrero, JoséBarrero-Villar, MartaRey, MercedesMittelbrunn, MaríaLamana Domínguez, AmaliaMorlino, GiuliaCalabia, CarmenYamazaki, HiroyukiShirao, TomoakiVázquez, JesúsGonzález-Amaro, RobertoVeiga, EstebanSánchez-Madrid, Francisco576577.1Actin cytoskeletonCXCR4Immune synapseBiología celular (Biología)Bioquímica (Biología)2407 Biología Celular2403 BioquímicaThe adaptive immune response depends on the interaction of T cells and antigen-presenting cells at the immune synapse. Formation of the immune synapse and the subsequent T-cell activation are highly dependent on the actin cytoskeleton. In this work, we describe that T cells express drebrin, a neuronal actin-binding protein. Drebrin colocalizes with the chemokine receptor CXCR4 and F-actin at the peripheral supramolecular activation cluster in the immune synapse. Drebrin interacts with the cytoplasmic tail of CXCR4 and both proteins redistribute to the immune synapse with similar kinetics. Drebrin knockdown in T cells impairs the redistribution of CXCR4 and inhibits actin polymerization at the immune synapse as well as IL-2 production. Our data indicate that drebrin exerts an unexpected and relevant functional role in T cells during the generation of the immune response.The Company of BiologistsUniversidad Complutense de Madrid20102010-01-0120102010-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/96255reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/962552026-06-02T12:44:21Z
dc.title.none.fl_str_mv F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse
title F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse
spellingShingle F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse
Pérez-Martínez, Manuel
576
577.1
Actin cytoskeleton
CXCR4
Immune synapse
Biología celular (Biología)
Bioquímica (Biología)
2407 Biología Celular
2403 Bioquímica
title_short F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse
title_full F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse
title_fullStr F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse
title_full_unstemmed F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse
title_sort F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse
dc.creator.none.fl_str_mv Pérez-Martínez, Manuel
Gordón-Alonso, Mónica
Román Cabrero, José
Barrero-Villar, Marta
Rey, Mercedes
Mittelbrunn, María
Lamana Domínguez, Amalia
Morlino, Giulia
Calabia, Carmen
Yamazaki, Hiroyuki
Shirao, Tomoaki
Vázquez, Jesús
González-Amaro, Roberto
Veiga, Esteban
Sánchez-Madrid, Francisco
author Pérez-Martínez, Manuel
author_facet Pérez-Martínez, Manuel
Gordón-Alonso, Mónica
Román Cabrero, José
Barrero-Villar, Marta
Rey, Mercedes
Mittelbrunn, María
Lamana Domínguez, Amalia
Morlino, Giulia
Calabia, Carmen
Yamazaki, Hiroyuki
Shirao, Tomoaki
Vázquez, Jesús
González-Amaro, Roberto
Veiga, Esteban
Sánchez-Madrid, Francisco
author_role author
author2 Gordón-Alonso, Mónica
Román Cabrero, José
Barrero-Villar, Marta
Rey, Mercedes
Mittelbrunn, María
Lamana Domínguez, Amalia
Morlino, Giulia
Calabia, Carmen
Yamazaki, Hiroyuki
Shirao, Tomoaki
Vázquez, Jesús
González-Amaro, Roberto
Veiga, Esteban
Sánchez-Madrid, Francisco
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 576
577.1
Actin cytoskeleton
CXCR4
Immune synapse
Biología celular (Biología)
Bioquímica (Biología)
2407 Biología Celular
2403 Bioquímica
topic 576
577.1
Actin cytoskeleton
CXCR4
Immune synapse
Biología celular (Biología)
Bioquímica (Biología)
2407 Biología Celular
2403 Bioquímica
description The adaptive immune response depends on the interaction of T cells and antigen-presenting cells at the immune synapse. Formation of the immune synapse and the subsequent T-cell activation are highly dependent on the actin cytoskeleton. In this work, we describe that T cells express drebrin, a neuronal actin-binding protein. Drebrin colocalizes with the chemokine receptor CXCR4 and F-actin at the peripheral supramolecular activation cluster in the immune synapse. Drebrin interacts with the cytoplasmic tail of CXCR4 and both proteins redistribute to the immune synapse with similar kinetics. Drebrin knockdown in T cells impairs the redistribution of CXCR4 and inhibits actin polymerization at the immune synapse as well as IL-2 production. Our data indicate that drebrin exerts an unexpected and relevant functional role in T cells during the generation of the immune response.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01
2010
2010-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/96255
url https://hdl.handle.net/20.500.14352/96255
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Company of Biologists
publisher.none.fl_str_mv The Company of Biologists
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422527390941184
score 15.812455

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