Vitamin D status in distinct types of ichthyosis: Importance of genetic type and severity of scaling

Data on vitamin D status of patients with inherited ichthyosis in Europe is scarce and unspecific concerning the genetic subtype. This study determined serum levels of 25-hydroxyvitamin D3 (25(OH)D3) in 87 patients with ichthyosis; 69 patients were additionally analysed for parathyroid hormone. Vita...

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Autores: Kim, Mi-Ran, Oji, Vinzenz, Valentin, Frederic, Traupe, Heiko, Nofer, Jerzy-Roch, Hausser, Ingrid, Hennies, Hans Christian, Eckl, Katja, Wudy, Stefan A., Sánchez-Guijo, Alberto, Kerschke, Laura, Fischer, Judith, Süßmuth, Kira
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/263680
Acesso em linha:http://hdl.handle.net/10261/263680
Access Level:acceso abierto
Palavra-chave:Ichthyosis
Vitamin D deficiency
Parathyroid hormone
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spelling Vitamin D status in distinct types of ichthyosis: Importance of genetic type and severity of scalingKim, Mi-RanOji, VinzenzValentin, FredericTraupe, HeikoNofer, Jerzy-RochHausser, IngridHennies, Hans ChristianEckl, KatjaWudy, Stefan A.Sánchez-Guijo, AlbertoKerschke, LauraFischer, JudithSüßmuth, KiraIchthyosisVitamin D deficiencyParathyroid hormoneData on vitamin D status of patients with inherited ichthyosis in Europe is scarce and unspecific concerning the genetic subtype. This study determined serum levels of 25-hydroxyvitamin D3 (25(OH)D3) in 87 patients with ichthyosis; 69 patients were additionally analysed for parathyroid hormone. Vitamin D deficiency was pronounced in keratinopathic ichthyosis (n = 17; median 25(OH)D3: 10.5 ng/ml), harlequin ichthyosis (n = 2;7.0 ng/ml) and rare syndromic subtypes (n = 3; 7.0 ng/ml). Vitamin D levels were reduced in TG1-proficient lamellar ichthyosis (n = 15; 8.9 ng/ml), TG1-deficient lamellar ichthyosis (n = 12; 11.7 ng/ml), congenital ichthyosiform erythroderma (n = 13; 12.4 ng/ml), Netherton syndrome (n = 7; 10.7 ng/ml) and X-linked ichthyosis (n = 8; 13.9 ng/ml). In ichthyosis vulgaris 25(OH)D3 levels were higher (n = 10; 19.7 ng/ml). Parathyroid hormone was elevated in 12 patients. Low 25(OH)D3 levels were associated with high severity of scaling (p = 0.03) implicating scaling as a risk factor for vitamin D deficiency. Thus, this study supports our recent guidelines for ichthyoses, which recommend screening for and substituting of vitamin D deficiency.This study was supported by the Selbsthilfe Ichthyose e.V., the Medical Faculty of the University of Münster (OJI120817 & OJ111409) and of the German Research Foundation (DFG OJ 53/3-1). It is part of the medical thesis of Mi-Ran Kim. The work was supported by the Selbsthilfe Ichthyose e.V., the Medical Faculty of the University of Muenster (OJI120817 & OJ111409) and by the German Research Foundation (DFG OJ 53/3-1). Furthermore, we cooperated with members of the European Reference Network (ERN, subgroup ERN-skin). The cohort of this paper was also part of a project funded by the programme “Innovative Medizinische Forschung” (IMF); project number: SÜ212007.Society for Publication of Acta Dermato-VenereologicaSelbsthilfe IchthyoseUniversity of MünsterGerman Research FoundationConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/263680reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.2340/00015555-3887Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2636802026-05-22T06:33:51Z
dc.title.none.fl_str_mv Vitamin D status in distinct types of ichthyosis: Importance of genetic type and severity of scaling
title Vitamin D status in distinct types of ichthyosis: Importance of genetic type and severity of scaling
spellingShingle Vitamin D status in distinct types of ichthyosis: Importance of genetic type and severity of scaling
Kim, Mi-Ran
Ichthyosis
Vitamin D deficiency
Parathyroid hormone
title_short Vitamin D status in distinct types of ichthyosis: Importance of genetic type and severity of scaling
title_full Vitamin D status in distinct types of ichthyosis: Importance of genetic type and severity of scaling
title_fullStr Vitamin D status in distinct types of ichthyosis: Importance of genetic type and severity of scaling
title_full_unstemmed Vitamin D status in distinct types of ichthyosis: Importance of genetic type and severity of scaling
title_sort Vitamin D status in distinct types of ichthyosis: Importance of genetic type and severity of scaling
dc.creator.none.fl_str_mv Kim, Mi-Ran
Oji, Vinzenz
Valentin, Frederic
Traupe, Heiko
Nofer, Jerzy-Roch
Hausser, Ingrid
Hennies, Hans Christian
Eckl, Katja
Wudy, Stefan A.
Sánchez-Guijo, Alberto
Kerschke, Laura
Fischer, Judith
Süßmuth, Kira
author Kim, Mi-Ran
author_facet Kim, Mi-Ran
Oji, Vinzenz
Valentin, Frederic
Traupe, Heiko
Nofer, Jerzy-Roch
Hausser, Ingrid
Hennies, Hans Christian
Eckl, Katja
Wudy, Stefan A.
Sánchez-Guijo, Alberto
Kerschke, Laura
Fischer, Judith
Süßmuth, Kira
author_role author
author2 Oji, Vinzenz
Valentin, Frederic
Traupe, Heiko
Nofer, Jerzy-Roch
Hausser, Ingrid
Hennies, Hans Christian
Eckl, Katja
Wudy, Stefan A.
Sánchez-Guijo, Alberto
Kerschke, Laura
Fischer, Judith
Süßmuth, Kira
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Selbsthilfe Ichthyose
University of Münster
German Research Foundation
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ichthyosis
Vitamin D deficiency
Parathyroid hormone
topic Ichthyosis
Vitamin D deficiency
Parathyroid hormone
description Data on vitamin D status of patients with inherited ichthyosis in Europe is scarce and unspecific concerning the genetic subtype. This study determined serum levels of 25-hydroxyvitamin D3 (25(OH)D3) in 87 patients with ichthyosis; 69 patients were additionally analysed for parathyroid hormone. Vitamin D deficiency was pronounced in keratinopathic ichthyosis (n = 17; median 25(OH)D3: 10.5 ng/ml), harlequin ichthyosis (n = 2;7.0 ng/ml) and rare syndromic subtypes (n = 3; 7.0 ng/ml). Vitamin D levels were reduced in TG1-proficient lamellar ichthyosis (n = 15; 8.9 ng/ml), TG1-deficient lamellar ichthyosis (n = 12; 11.7 ng/ml), congenital ichthyosiform erythroderma (n = 13; 12.4 ng/ml), Netherton syndrome (n = 7; 10.7 ng/ml) and X-linked ichthyosis (n = 8; 13.9 ng/ml). In ichthyosis vulgaris 25(OH)D3 levels were higher (n = 10; 19.7 ng/ml). Parathyroid hormone was elevated in 12 patients. Low 25(OH)D3 levels were associated with high severity of scaling (p = 0.03) implicating scaling as a risk factor for vitamin D deficiency. Thus, this study supports our recent guidelines for ichthyoses, which recommend screening for and substituting of vitamin D deficiency.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/263680
url http://hdl.handle.net/10261/263680
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.2340/00015555-3887
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Society for Publication of Acta Dermato-Venereologica
publisher.none.fl_str_mv Society for Publication of Acta Dermato-Venereologica
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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