Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer

Breast cancer fertility; Pregnancy; Survival

Detalles Bibliográficos
Autores: Condorelli, Margherita, Bruzzone, M., Ceppi, Marcello, Ferrari, A., Grinshpun, A., Carrasco López, Estela, Balmaña Gelpí, Judith, Hamy, Anne-Sophie
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7520
Acceso en línea:https://hdl.handle.net/11351/7520
Access Level:acceso abierto
Palabra clave:Reproducció humana assistida
Mama - Càncer - Aspectes genètics
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Reproductive Techniques::Reproductive Techniques, Assisted
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas reproductivas::técnicas reproductivas asistidas
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
id ES_e0dc94f7b7ec8fcbfc4b331e229954cf
oai_identifier_str oai:recercat.cat:11351/7520
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer
title Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer
spellingShingle Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer
Condorelli, Margherita
Reproducció humana assistida
Mama - Càncer - Aspectes genètics
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Reproductive Techniques::Reproductive Techniques, Assisted
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas reproductivas::técnicas reproductivas asistidas
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
title_short Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer
title_full Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer
title_fullStr Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer
title_full_unstemmed Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer
title_sort Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancer
dc.creator.none.fl_str_mv Condorelli, Margherita
Bruzzone, M.
Ceppi, Marcello
Ferrari, A.
Grinshpun, A.
Carrasco López, Estela
Balmaña Gelpí, Judith
Hamy, Anne-Sophie
author Condorelli, Margherita
author_facet Condorelli, Margherita
Bruzzone, M.
Ceppi, Marcello
Ferrari, A.
Grinshpun, A.
Carrasco López, Estela
Balmaña Gelpí, Judith
Hamy, Anne-Sophie
author_role author
author2 Bruzzone, M.
Ceppi, Marcello
Ferrari, A.
Grinshpun, A.
Carrasco López, Estela
Balmaña Gelpí, Judith
Hamy, Anne-Sophie
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Condorelli M] Department of Obstetrics and Gynecology, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.), Fertility Clinic, Brussels. Research Laboratory on Human Reproduction, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium. [Bruzzone M, Ceppi M] Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova. [Ferrari A] Department of Surgical Sciences, General Surgery III-Breast Surgery, Fondazione IRCCS Policlinico San Matteo, Pavia. Department of Clinical Surgical Sciences, University of Pavia, Pavia, Italy. [Grinshpun A] Breast Oncology Unit Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. [Hamy AS] Department of Medical Oncology, Institut Curie, Paris, France. [Carrasco E, Balmaña J] Hereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Reproducció humana assistida
Mama - Càncer - Aspectes genètics
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Reproductive Techniques::Reproductive Techniques, Assisted
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas reproductivas::técnicas reproductivas asistidas
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
topic Reproducció humana assistida
Mama - Càncer - Aspectes genètics
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Reproductive Techniques::Reproductive Techniques, Assisted
Other subheadings::Other subheadings::Other subheadings::/adverse effects
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas reproductivas::técnicas reproductivas asistidas
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
description Breast cancer fertility; Pregnancy; Survival
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7520
url https://hdl.handle.net/11351/7520
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv ESMO Open;6(6)
https://doi.org/10.1016/j.esmoop.2021.100300
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422241042661376
spelling Safety of assisted reproductive techniques in young women harboring germline pathogenic variants in BRCA1/2 with a pregnancy after prior history of breast cancerCondorelli, MargheritaBruzzone, M.Ceppi, MarcelloFerrari, A.Grinshpun, A.Carrasco López, EstelaBalmaña Gelpí, JudithHamy, Anne-SophieReproducció humana assistidaMama - Càncer - Aspectes genèticsDISEASES::Neoplasms::Neoplasms by Site::Breast NeoplasmsANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Reproductive Techniques::Reproductive Techniques, AssistedOther subheadings::Other subheadings::Other subheadings::/adverse effectsENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mamaTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas reproductivas::técnicas reproductivas asistidasOtros calificadores::Otros calificadores::Otros calificadores::/efectos adversosBreast cancer fertility; Pregnancy; SurvivalFertilidad y cáncer de mama; Embarazo; SupervivenciaFertilitat i càncer de mama; Embaràs; SupervivènciaBackground Knowledge is growing on the safety of assisted reproductive techniques (ART) in cancer survivors. No data exist, however, for the specific population of breast cancer patients harboring germline BRCA1/2 pathogenic variants. Patients and methods This is a multicenter retrospective cohort study across 30 centers worldwide including women diagnosed at ≤40 years with stage I-III breast cancer, between January 2000 and December 2012, harboring known germline BRCA1/2 pathogenic variants. Patients included in this analysis had a post-treatment pregnancy either achieved through use of ART (ART group) or naturally (non-ART group). ART procedures included ovulation induction, ovarian stimulation for in vitro fertilization or intracytoplasmic sperm injection, and embryo transfer under hormonal replacement therapy. Results Among the 1424 patients registered in the study, 168 were eligible for inclusion in the present analysis, of whom 22 were in the ART group and 146 in the non-ART group. Survivors in the ART group conceived at an older age compared with those in the non-ART group (median age: 39.7 versus 35.4 years, respectively). Women in the ART group experienced more delivery complications compared with those in the non-ART group (22.1% versus 4.1%, respectively). No other apparent differences in obstetrical outcomes were observed between cohorts. The median follow-up from pregnancy was 3.4 years (range: 0.8-8.6 years) in the ART group and 5.0 years (range: 0.8-17.6 years) in the non-ART group. Two patients (9.1%) in the ART group experienced a disease-free survival event (specifically, a locoregional recurrence) compared with 40 patients (27.4%) in the non-ART group. In the ART group, no patients deceased compared with 10 patients (6.9%) in the non-ART group. Conclusion This study provides encouraging safety data on the use of ART in breast cancer survivors harboring germline pathogenic variants in BRCA1/2, when natural conception fails or when they opt for ART in order to carry out preimplantation genetic testing.The present work was supported by the Italian Association for Cancer Research (‘Associazione Italiana per la Ricerca sul Cancro’, AIRC; MFAG 2020 ID 24698) and the Italian Ministry of Health (5 × 1000 funds 2017). MC and ID acknowledge the Fonds National de la Recherche Scientifique (FNRS and Télévie 7.6508.20) and Fonds Erasme for their financial support.ElsevierInstitut Català de la Salut[Condorelli M] Department of Obstetrics and Gynecology, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.), Fertility Clinic, Brussels. Research Laboratory on Human Reproduction, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium. [Bruzzone M, Ceppi M] Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova. [Ferrari A] Department of Surgical Sciences, General Surgery III-Breast Surgery, Fondazione IRCCS Policlinico San Matteo, Pavia. Department of Clinical Surgical Sciences, University of Pavia, Pavia, Italy. [Grinshpun A] Breast Oncology Unit Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. [Hamy AS] Department of Medical Oncology, Institut Curie, Paris, France. [Carrasco E, Balmaña J] Hereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7520Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésESMO Open;6(6)https://doi.org/10.1016/j.esmoop.2021.100300Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/75202026-05-29T05:05:01Z
score 15,228081

Similares en LA Referencia