Metabolipidomic Analysis in Patients with Obstructive Sleep Apnea Discloses a Circulating Metabotype of Non-Dipping Blood Pressure

A non-dipping blood pressure (BP) pattern, which is frequently present in patients with obstructive sleep apnea (OSA), confers high cardiovascular risk. The mechanisms connecting these two conditions remain unclear. In the present study we performed a comprehensive analysis of the blood metabolipido...

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Autores: Pinilla, Lucía, Benítez, Iván, Gracia-Lavedan, Esther, Torres, Gerard, Minguez Roure, Olga, Vaca, Rafaela, Jové Font, Mariona, Sol, Joaquim, Pamplona Gras, Reinald, Barbé Illa, Ferran, Sánchez de la Torre, Manuel
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Universitat de Lleida (UdL)
Repositório:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/465632
Acesso em linha:https://doi.org/10.3390/antiox12122047
https://hdl.handle.net/10459.1/465632
Access Level:Acceso aberto
Palavra-chave:Obstructive sleep apnea
Blood pressure
Non-dipping
Metabolomic
Lipidomic
Metabolic pathways
CPAP
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spelling Metabolipidomic Analysis in Patients with Obstructive Sleep Apnea Discloses a Circulating Metabotype of Non-Dipping Blood PressurePinilla, LucíaBenítez, IvánGracia-Lavedan, EstherTorres, GerardMinguez Roure, OlgaVaca, RafaelaJové Font, MarionaSol, JoaquimPamplona Gras, ReinaldBarbé Illa, FerranSánchez de la Torre, ManuelObstructive sleep apneaBlood pressureNon-dippingMetabolomicLipidomicMetabolic pathwaysCPAPA non-dipping blood pressure (BP) pattern, which is frequently present in patients with obstructive sleep apnea (OSA), confers high cardiovascular risk. The mechanisms connecting these two conditions remain unclear. In the present study we performed a comprehensive analysis of the blood metabolipidome that aims to provide new insights into the molecular link between OSA and the dysregulation of circadian BP rhythmicity. This was an observational prospective longitudinal study involving adults with suspected OSA who were subjected to full polysomnography (PSG). Patients with an apnea-hypopnea index ≥ 5 events/h were included. Fasting plasma samples were obtained the morning after PSG. Based on the dipping ratio (DR; ratio of night/day BP values) measured via 24 h ambulatory BP monitoring, two groups were established: dippers (DR ≤ 0.9) and non-dippers (DR > 0.9). Treatment recommendations for OSA followed the clinical guidelines. Untargeted metabolomic and lipidomic analyses were performed in plasma samples via liquid chromatography-tandem mass spectrometry. Non-dipper patients represented 53.7% of the cohort (88/164 patients). A set of 31 metabolic species and 13 lipidic species were differentially detected between OSA patients who present a physiologic nocturnal BP decrease and those with abnormal BP dipping. Among the 44 differentially abundant plasma compounds, 25 were putatively identified, notably glycerophospholipids, glycolipids, sterols, and fatty acid derivates. Multivariate analysis defined a specific metabotype of non-dipping BP, which showed a significant dose-response relationship with PSG parameters of OSA severity, and with BP dipping changes after 6 months of OSA treatment with continuous positive airway pressure (CPAP). Bioinformatic analyses revealed that the identified metabolipidomic profile was found to be implicated in multiple systemic biological pathways, with potential physiopathologic implications for the circadian control of BP among individuals with OSA.This research was funded by Instituto de Salud Carlos III (ISCIII), grant number PI21/00337, co-funded by the European Union; IRBLleida—Fundació Dr. Pifarré; CERCA Programme/Generalitat de Catalunya; and Soeciedad Española de Neumoología y Cirugía Torácica (SEPAR), grant number 1209/2022. We thank the individuals who participated in this trial, their families, and the clinical and research team in the sleep unit. L.P. was the recipient of a predoctoral fellowship from the Ministry of Universities of Spain (FPU19/01555). M.S.-d.-l.-T. has received financial support from the “Ramón y Cajal” grant (RYC2019-027831-I) from the “Ministerio de Ciencia e Innovación—Agencia Estatal de Investigación” co-funded by the European Social Fund (ESF)/“Investing in your future”.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/antiox12122047https://hdl.handle.net/10459.1/465632reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a: https://doi.org/10.3390/antiox12122047Antioxidants, 2023, vol. 12, num. 12, p. 2047cc-by (c) Authors, 2023info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/4656322026-06-24T12:42:17Z
dc.title.none.fl_str_mv Metabolipidomic Analysis in Patients with Obstructive Sleep Apnea Discloses a Circulating Metabotype of Non-Dipping Blood Pressure
title Metabolipidomic Analysis in Patients with Obstructive Sleep Apnea Discloses a Circulating Metabotype of Non-Dipping Blood Pressure
spellingShingle Metabolipidomic Analysis in Patients with Obstructive Sleep Apnea Discloses a Circulating Metabotype of Non-Dipping Blood Pressure
Pinilla, Lucía
Obstructive sleep apnea
Blood pressure
Non-dipping
Metabolomic
Lipidomic
Metabolic pathways
CPAP
title_short Metabolipidomic Analysis in Patients with Obstructive Sleep Apnea Discloses a Circulating Metabotype of Non-Dipping Blood Pressure
title_full Metabolipidomic Analysis in Patients with Obstructive Sleep Apnea Discloses a Circulating Metabotype of Non-Dipping Blood Pressure
title_fullStr Metabolipidomic Analysis in Patients with Obstructive Sleep Apnea Discloses a Circulating Metabotype of Non-Dipping Blood Pressure
title_full_unstemmed Metabolipidomic Analysis in Patients with Obstructive Sleep Apnea Discloses a Circulating Metabotype of Non-Dipping Blood Pressure
title_sort Metabolipidomic Analysis in Patients with Obstructive Sleep Apnea Discloses a Circulating Metabotype of Non-Dipping Blood Pressure
dc.creator.none.fl_str_mv Pinilla, Lucía
Benítez, Iván
Gracia-Lavedan, Esther
Torres, Gerard
Minguez Roure, Olga
Vaca, Rafaela
Jové Font, Mariona
Sol, Joaquim
Pamplona Gras, Reinald
Barbé Illa, Ferran
Sánchez de la Torre, Manuel
author Pinilla, Lucía
author_facet Pinilla, Lucía
Benítez, Iván
Gracia-Lavedan, Esther
Torres, Gerard
Minguez Roure, Olga
Vaca, Rafaela
Jové Font, Mariona
Sol, Joaquim
Pamplona Gras, Reinald
Barbé Illa, Ferran
Sánchez de la Torre, Manuel
author_role author
author2 Benítez, Iván
Gracia-Lavedan, Esther
Torres, Gerard
Minguez Roure, Olga
Vaca, Rafaela
Jové Font, Mariona
Sol, Joaquim
Pamplona Gras, Reinald
Barbé Illa, Ferran
Sánchez de la Torre, Manuel
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obstructive sleep apnea
Blood pressure
Non-dipping
Metabolomic
Lipidomic
Metabolic pathways
CPAP
topic Obstructive sleep apnea
Blood pressure
Non-dipping
Metabolomic
Lipidomic
Metabolic pathways
CPAP
description A non-dipping blood pressure (BP) pattern, which is frequently present in patients with obstructive sleep apnea (OSA), confers high cardiovascular risk. The mechanisms connecting these two conditions remain unclear. In the present study we performed a comprehensive analysis of the blood metabolipidome that aims to provide new insights into the molecular link between OSA and the dysregulation of circadian BP rhythmicity. This was an observational prospective longitudinal study involving adults with suspected OSA who were subjected to full polysomnography (PSG). Patients with an apnea-hypopnea index ≥ 5 events/h were included. Fasting plasma samples were obtained the morning after PSG. Based on the dipping ratio (DR; ratio of night/day BP values) measured via 24 h ambulatory BP monitoring, two groups were established: dippers (DR ≤ 0.9) and non-dippers (DR > 0.9). Treatment recommendations for OSA followed the clinical guidelines. Untargeted metabolomic and lipidomic analyses were performed in plasma samples via liquid chromatography-tandem mass spectrometry. Non-dipper patients represented 53.7% of the cohort (88/164 patients). A set of 31 metabolic species and 13 lipidic species were differentially detected between OSA patients who present a physiologic nocturnal BP decrease and those with abnormal BP dipping. Among the 44 differentially abundant plasma compounds, 25 were putatively identified, notably glycerophospholipids, glycolipids, sterols, and fatty acid derivates. Multivariate analysis defined a specific metabotype of non-dipping BP, which showed a significant dose-response relationship with PSG parameters of OSA severity, and with BP dipping changes after 6 months of OSA treatment with continuous positive airway pressure (CPAP). Bioinformatic analyses revealed that the identified metabolipidomic profile was found to be implicated in multiple systemic biological pathways, with potential physiopathologic implications for the circadian control of BP among individuals with OSA.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/antiox12122047
https://hdl.handle.net/10459.1/465632
url https://doi.org/10.3390/antiox12122047
https://hdl.handle.net/10459.1/465632
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antiox12122047
Antioxidants, 2023, vol. 12, num. 12, p. 2047
dc.rights.none.fl_str_mv cc-by (c) Authors, 2023
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Authors, 2023
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
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repository.mail.fl_str_mv
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