The associations of air pollution mixture exposure with plasma proteins in an elderly U.S. panel
The impact of air pollution exposure on circulating proteins remains underexplored, particularly in vulnerable elderly populations. This study investigated the individual and joint effects of air pollutants on circulating proteins in 208 elderly participants from the Cancer Prevention Study-II Nutri...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:dnet:rdupf_______::2a606c3fd08dc09e1f02631792218ed9 |
| Acceso en línea: | https://hdl.handle.net/10230/73449 http://dx.doi.org/10.1021/acs.est.5c03052 |
| Access Level: | acceso abierto |
| Palabra clave: | Air pollution Immune responses Inflammation Long-term exposure Mixture Proteins Signaling |
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The associations of air pollution mixture exposure with plasma proteins in an elderly U.S. panelTang, ZiyinWang, YingSarnat, Jeremy A.Diver, W. RyanEverson, Todd M.Deubler, Emily L.Tan, YouranEick, Stephanie M.Kesarwala, Aparna HTurner, Michelle C.Marsit, Carmen J.Johansson, MattiasRobbins, Hilary ALiang, DonghaiAir pollutionImmune responsesInflammationLong-term exposureMixtureProteinsSignalingThe impact of air pollution exposure on circulating proteins remains underexplored, particularly in vulnerable elderly populations. This study investigated the individual and joint effects of air pollutants on circulating proteins in 208 elderly participants from the Cancer Prevention Study-II Nutrition Cohort. Prediagnostic plasma samples were collected (1998-2001), and 484 proteins were measured using the Olink platform. Annual average exposures to six air pollutants in the calendar year of blood draw were estimated. We used linear regression for individual pollutants and quantile g-computation for mixture effects, adjusting for confounders, considering multiple comparison correction, and testing interactions with smoking status. Pathway enrichment and protein-protein interaction analyses were conducted for the associated proteins. We identified 167 distinct proteins associated with individual pollutants or mixtures (p < 0.05), including 15 meeting a false discovery rate <0.2. IL32, ADAM15, and IL8 demonstrated consistent negative associations with ≥4 exposure metrics. Twenty proteins were associated with both mixtures and individual air pollutants with consistent effect directions. These proteins were enriched in pathways linked to immunity and signaling. Stratified analyses revealed differing associations with 99 proteins between current and former smokers. The findings offer valuable insight into the chronic biological response in plasma protein levels to air pollution exposure.The American Cancer Society funds the creation, maintenance, and updating of the Cancer Prevention Study-II cohort. Support for this project is provided by the Michel and Claire Gudefin Family Foundation Inc. ZT is supported by the National Cancer Institute (NCI) F99/K00 Award [F99CA294242]. We also acknowledge support from the National Institutes of Health (NIH) research grants [R21ES032117, R01ES035738] and the HERCULES Exposome Research Center, supported by the National Institute of Environmental Health Sciences of the NIH (P30ES019776). MCT is funded by a Ramon y Cajal fellowship (RYC-2017- 01892) from the Spanish Ministry of Science, nnovation and Universities and cofunded by the European Social Fund. ISGlobal acknowledges support from the grant CEX2023- 0001290-S funded by MCIN/AEI/10.13039/501100011033, as well as support from the Generalitat de Catalunya through the CERCA Program.American Chemical Society (ACS)2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/73449http://dx.doi.org/10.1021/acs.est.5c03052reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEnvironmental Science and Technology. 2025;59(30):15692-704info:eu-repo/grantAgreement/ES/3PE/CEX2023-0001290-S© 2025 The Authors. Published by American Chemical Society. This article is licensed under CC-BY 4.0 (http://creativecommons.org/licenses/by/4.0/)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:rdupf_______::2a606c3fd08dc09e1f02631792218ed92026-06-12T07:21:37Z |
| dc.title.none.fl_str_mv |
The associations of air pollution mixture exposure with plasma proteins in an elderly U.S. panel |
| title |
The associations of air pollution mixture exposure with plasma proteins in an elderly U.S. panel |
| spellingShingle |
The associations of air pollution mixture exposure with plasma proteins in an elderly U.S. panel Tang, Ziyin Air pollution Immune responses Inflammation Long-term exposure Mixture Proteins Signaling |
| title_short |
The associations of air pollution mixture exposure with plasma proteins in an elderly U.S. panel |
| title_full |
The associations of air pollution mixture exposure with plasma proteins in an elderly U.S. panel |
| title_fullStr |
The associations of air pollution mixture exposure with plasma proteins in an elderly U.S. panel |
| title_full_unstemmed |
The associations of air pollution mixture exposure with plasma proteins in an elderly U.S. panel |
| title_sort |
The associations of air pollution mixture exposure with plasma proteins in an elderly U.S. panel |
| dc.creator.none.fl_str_mv |
Tang, Ziyin Wang, Ying Sarnat, Jeremy A. Diver, W. Ryan Everson, Todd M. Deubler, Emily L. Tan, Youran Eick, Stephanie M. Kesarwala, Aparna H Turner, Michelle C. Marsit, Carmen J. Johansson, Mattias Robbins, Hilary A Liang, Donghai |
| author |
Tang, Ziyin |
| author_facet |
Tang, Ziyin Wang, Ying Sarnat, Jeremy A. Diver, W. Ryan Everson, Todd M. Deubler, Emily L. Tan, Youran Eick, Stephanie M. Kesarwala, Aparna H Turner, Michelle C. Marsit, Carmen J. Johansson, Mattias Robbins, Hilary A Liang, Donghai |
| author_role |
author |
| author2 |
Wang, Ying Sarnat, Jeremy A. Diver, W. Ryan Everson, Todd M. Deubler, Emily L. Tan, Youran Eick, Stephanie M. Kesarwala, Aparna H Turner, Michelle C. Marsit, Carmen J. Johansson, Mattias Robbins, Hilary A Liang, Donghai |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Air pollution Immune responses Inflammation Long-term exposure Mixture Proteins Signaling |
| topic |
Air pollution Immune responses Inflammation Long-term exposure Mixture Proteins Signaling |
| description |
The impact of air pollution exposure on circulating proteins remains underexplored, particularly in vulnerable elderly populations. This study investigated the individual and joint effects of air pollutants on circulating proteins in 208 elderly participants from the Cancer Prevention Study-II Nutrition Cohort. Prediagnostic plasma samples were collected (1998-2001), and 484 proteins were measured using the Olink platform. Annual average exposures to six air pollutants in the calendar year of blood draw were estimated. We used linear regression for individual pollutants and quantile g-computation for mixture effects, adjusting for confounders, considering multiple comparison correction, and testing interactions with smoking status. Pathway enrichment and protein-protein interaction analyses were conducted for the associated proteins. We identified 167 distinct proteins associated with individual pollutants or mixtures (p < 0.05), including 15 meeting a false discovery rate <0.2. IL32, ADAM15, and IL8 demonstrated consistent negative associations with ≥4 exposure metrics. Twenty proteins were associated with both mixtures and individual air pollutants with consistent effect directions. These proteins were enriched in pathways linked to immunity and signaling. Stratified analyses revealed differing associations with 99 proteins between current and former smokers. The findings offer valuable insight into the chronic biological response in plasma protein levels to air pollution exposure. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2026 2026 2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10230/73449 http://dx.doi.org/10.1021/acs.est.5c03052 |
| url |
https://hdl.handle.net/10230/73449 http://dx.doi.org/10.1021/acs.est.5c03052 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
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Environmental Science and Technology. 2025;59(30):15692-704 info:eu-repo/grantAgreement/ES/3PE/CEX2023-0001290-S |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
American Chemical Society (ACS) |
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American Chemical Society (ACS) |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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Repositorio Digital de la UPF |
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