Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis

[EN]Thrombosis is frequent in patients with Behçet's disease (BD), although the exact cause remains uncertain. Some single nucleotide polymorphism (SNP) (G1691A in factor V gene, also called factor V Leiden [FVL], G20210A in prothrombin gene and C677T in methyltetrahydrofolate reductase [MTHFR]...

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Autores: Chamorro Fernández, Antonio Javier, Marcos Martín, Miguel, Hernández-García, Ignacio, Calvo, Antonia, Mejia, Juan-Carlos, Cervera Segura, Ricard, Espinosa Garriga, Gerard
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/154048
Acceso en línea:http://hdl.handle.net/10366/154048
Access Level:acceso embargado
Palabra clave:Behcet syndrome
Factor V
Prothrombin
Methylenetetrahydrofolate reductase
Polymorphism
Genetic
Meta-analysis
Behcet Syndrome
Meta-Analysis
Polymorphism, Genetic
polimorfismo genético
factor V
protrombina
síndrome de Behçet
metanálisis
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spelling Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysisChamorro Fernández, Antonio JavierMarcos Martín, MiguelHernández-García, IgnacioCalvo, AntoniaMejia, Juan-CarlosCervera Segura, RicardEspinosa Garriga, GerardBehcet syndromeFactor VProthrombinMethylenetetrahydrofolate reductasePolymorphismGeneticMeta-analysisFactor VBehcet SyndromeMeta-AnalysisProthrombinPolymorphism, Geneticpolimorfismo genéticofactor Vprotrombinasíndrome de Behçetmetanálisis[EN]Thrombosis is frequent in patients with Behçet's disease (BD), although the exact cause remains uncertain. Some single nucleotide polymorphism (SNP) (G1691A in factor V gene, also called factor V Leiden [FVL], G20210A in prothrombin gene and C677T in methyltetrahydrofolate reductase [MTHFR] gene) have been associated with thrombosis and ocular involvement in BD with controversial results. Aim: To assess the effects of FVL, prothrombin and MTHFR SNP variants in patients with BD and thrombosis and ocular involvement by means of a systematic review and meta-analysis. Methods: We retrieved studies analyzing the genotype of the above-mentioned polymorphism among patients with BD. A meta-analysis was conducted in a random effects model and calculations of odds ratio (OR) and confidence intervals (CI) were done. Sensitivity analysis and tests for heterogeneity of the results were performed. Results: 27 previous studies analyzed the association of BD and thrombosis with the FVL, prothrombin and MTHFR polymorphisms. A significant association was found between the possession of the AA or GA genotypes of FVL polymorphism among patients with BD and the presence of any thrombosis (OR=2.51; 95% CI: 1.68, 3.74; Pb0.00001). In addition, a significant association was found between the possession of the GA or AA genotypes and the presence of BD (OR=2.67; 95% CI: 1.93. 3.72; Pb0.00001) when cases with BD and healthy controls were compared. This association was not found when studies from Turkey were excluded. No association was found between prothrombin and MTHFR SNPs and thrombosis in BD, and no association between any SNP and ocular involvement was shown either. Conclusions: Factor V Leiden could be responsible for some thrombotic events in at least Turkish patients. However, this relationship has to be demonstrated from a pathogenic point of viewElsevierinfo202420242013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/154048reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/embargoedAccessoai:gredos.usal.es:10366/1540482026-06-07T06:28:51Z
dc.title.none.fl_str_mv Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis
title Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis
spellingShingle Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis
Chamorro Fernández, Antonio Javier
Behcet syndrome
Factor V
Prothrombin
Methylenetetrahydrofolate reductase
Polymorphism
Genetic
Meta-analysis
Factor V
Behcet Syndrome
Meta-Analysis
Prothrombin
Polymorphism, Genetic
polimorfismo genético
factor V
protrombina
síndrome de Behçet
metanálisis
title_short Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis
title_full Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis
title_fullStr Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis
title_full_unstemmed Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis
title_sort Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Chamorro Fernández, Antonio Javier
Marcos Martín, Miguel
Hernández-García, Ignacio
Calvo, Antonia
Mejia, Juan-Carlos
Cervera Segura, Ricard
Espinosa Garriga, Gerard
author Chamorro Fernández, Antonio Javier
author_facet Chamorro Fernández, Antonio Javier
Marcos Martín, Miguel
Hernández-García, Ignacio
Calvo, Antonia
Mejia, Juan-Carlos
Cervera Segura, Ricard
Espinosa Garriga, Gerard
author_role author
author2 Marcos Martín, Miguel
Hernández-García, Ignacio
Calvo, Antonia
Mejia, Juan-Carlos
Cervera Segura, Ricard
Espinosa Garriga, Gerard
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Behcet syndrome
Factor V
Prothrombin
Methylenetetrahydrofolate reductase
Polymorphism
Genetic
Meta-analysis
Factor V
Behcet Syndrome
Meta-Analysis
Prothrombin
Polymorphism, Genetic
polimorfismo genético
factor V
protrombina
síndrome de Behçet
metanálisis
topic Behcet syndrome
Factor V
Prothrombin
Methylenetetrahydrofolate reductase
Polymorphism
Genetic
Meta-analysis
Factor V
Behcet Syndrome
Meta-Analysis
Prothrombin
Polymorphism, Genetic
polimorfismo genético
factor V
protrombina
síndrome de Behçet
metanálisis
description [EN]Thrombosis is frequent in patients with Behçet's disease (BD), although the exact cause remains uncertain. Some single nucleotide polymorphism (SNP) (G1691A in factor V gene, also called factor V Leiden [FVL], G20210A in prothrombin gene and C677T in methyltetrahydrofolate reductase [MTHFR] gene) have been associated with thrombosis and ocular involvement in BD with controversial results. Aim: To assess the effects of FVL, prothrombin and MTHFR SNP variants in patients with BD and thrombosis and ocular involvement by means of a systematic review and meta-analysis. Methods: We retrieved studies analyzing the genotype of the above-mentioned polymorphism among patients with BD. A meta-analysis was conducted in a random effects model and calculations of odds ratio (OR) and confidence intervals (CI) were done. Sensitivity analysis and tests for heterogeneity of the results were performed. Results: 27 previous studies analyzed the association of BD and thrombosis with the FVL, prothrombin and MTHFR polymorphisms. A significant association was found between the possession of the AA or GA genotypes of FVL polymorphism among patients with BD and the presence of any thrombosis (OR=2.51; 95% CI: 1.68, 3.74; Pb0.00001). In addition, a significant association was found between the possession of the GA or AA genotypes and the presence of BD (OR=2.67; 95% CI: 1.93. 3.72; Pb0.00001) when cases with BD and healthy controls were compared. This association was not found when studies from Turkey were excluded. No association was found between prothrombin and MTHFR SNPs and thrombosis in BD, and no association between any SNP and ocular involvement was shown either. Conclusions: Factor V Leiden could be responsible for some thrombotic events in at least Turkish patients. However, this relationship has to be demonstrated from a pathogenic point of view
publishDate 2013
dc.date.none.fl_str_mv 2013
2024
2024
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/154048
url http://hdl.handle.net/10366/154048
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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