Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysis

Anemia is a multifactorial condition influenced by nutritional deficiencies, chronic diseases, and inflammatory processes. These factors not only contribute to anemia but may also exacerbate oral conditions such as Oral Lichen Planus (OLP) by impairing epithelial integrity and immune function. By sy...

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Detalhes bibliográficos
Autores: Egido Moreno, Sonia, Valls Roca-Umbert, Joan, Schemel Suárez, Mayra, Vidal Bel, August, Blanco Carrión, Andrés, López López, José
Formato: artículo
Fecha de publicación:2026
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:dnet:minerva_____::670cdf2b8706c88a07023beb0ae96fa1
Acesso em linha:https://hdl.handle.net/10347/47270
Access Level:acceso abierto
Palavra-chave:Oral lichen planus
Anemia
Iron deficiency
Vitamin B12 deficiency
Folic acid deficiency
321313 Ortodoncia-estomatología
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spelling Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysisEgido Moreno, SoniaValls Roca-Umbert, JoanSchemel Suárez, MayraVidal Bel, AugustBlanco Carrión, AndrésLópez López, JoséOral lichen planusAnemiaIron deficiencyVitamin B12 deficiencyFolic acid deficiency321313 Ortodoncia-estomatologíaAnemia is a multifactorial condition influenced by nutritional deficiencies, chronic diseases, and inflammatory processes. These factors not only contribute to anemia but may also exacerbate oral conditions such as Oral Lichen Planus (OLP) by impairing epithelial integrity and immune function. By synthesizing published studies, this review seeks to clarify whether anemia is associated with OLP and to highlight biological mechanisms common to both conditions that could be relevant for future therapeutic development. Methods: A comprehensive literature search was conducted across the selected electronic databases: Medline/Pubmed, Scopus, and Cochrane. Methodological quality and potential bias of the included studies were evaluated using the Newcastle–Ottawa Scale (NOS), while the overall certainty of the evidence was appraised according to the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) framework. Forest plots were generated using the Cochrane RevMan software to evaluate and visually summarize the results of the included studies. Results: Application of the search strategy resulted in the identification of 549 articles; after applying exclusion and inclusion criteria, 11 papers were selected. The prevalence of anemia, iron deficiency, and folic acid deficiency was significantly increased in the study population (p < 0.05); whereas hemoglobin deficiency was observed exclusively in women with statistical significance (p < 0.00001), driven by a single large study. Conclusions: Patients with OLP show a higher prevalence of anemia and deficiencies in key hematologic micronutrients such as vitamin B12, folic acid, and iron. Routine laboratory evaluation is recommended to detect and manage these systemic alterations. In addition to corticosteroid therapy, micronutrient supplementation may serve as a useful complementary treatment approach.Multidisciplinary Digital Publishing Institute MDPIUniversidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas20262026-01-1120262026-01-11journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/47270reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2© 2026 by the authors. Creative Commons Attribution (CC BY) license.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:minerva_____::670cdf2b8706c88a07023beb0ae96fa12026-06-15T12:47:27Z
dc.title.none.fl_str_mv Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysis
title Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysis
spellingShingle Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysis
Egido Moreno, Sonia
Oral lichen planus
Anemia
Iron deficiency
Vitamin B12 deficiency
Folic acid deficiency
321313 Ortodoncia-estomatología
title_short Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysis
title_full Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysis
title_fullStr Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysis
title_full_unstemmed Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysis
title_sort Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Egido Moreno, Sonia
Valls Roca-Umbert, Joan
Schemel Suárez, Mayra
Vidal Bel, August
Blanco Carrión, Andrés
López López, José
author Egido Moreno, Sonia
author_facet Egido Moreno, Sonia
Valls Roca-Umbert, Joan
Schemel Suárez, Mayra
Vidal Bel, August
Blanco Carrión, Andrés
López López, José
author_role author
author2 Valls Roca-Umbert, Joan
Schemel Suárez, Mayra
Vidal Bel, August
Blanco Carrión, Andrés
López López, José
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
dc.subject.none.fl_str_mv Oral lichen planus
Anemia
Iron deficiency
Vitamin B12 deficiency
Folic acid deficiency
321313 Ortodoncia-estomatología
topic Oral lichen planus
Anemia
Iron deficiency
Vitamin B12 deficiency
Folic acid deficiency
321313 Ortodoncia-estomatología
description Anemia is a multifactorial condition influenced by nutritional deficiencies, chronic diseases, and inflammatory processes. These factors not only contribute to anemia but may also exacerbate oral conditions such as Oral Lichen Planus (OLP) by impairing epithelial integrity and immune function. By synthesizing published studies, this review seeks to clarify whether anemia is associated with OLP and to highlight biological mechanisms common to both conditions that could be relevant for future therapeutic development. Methods: A comprehensive literature search was conducted across the selected electronic databases: Medline/Pubmed, Scopus, and Cochrane. Methodological quality and potential bias of the included studies were evaluated using the Newcastle–Ottawa Scale (NOS), while the overall certainty of the evidence was appraised according to the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) framework. Forest plots were generated using the Cochrane RevMan software to evaluate and visually summarize the results of the included studies. Results: Application of the search strategy resulted in the identification of 549 articles; after applying exclusion and inclusion criteria, 11 papers were selected. The prevalence of anemia, iron deficiency, and folic acid deficiency was significantly increased in the study population (p < 0.05); whereas hemoglobin deficiency was observed exclusively in women with statistical significance (p < 0.00001), driven by a single large study. Conclusions: Patients with OLP show a higher prevalence of anemia and deficiencies in key hematologic micronutrients such as vitamin B12, folic acid, and iron. Routine laboratory evaluation is recommended to detect and manage these systemic alterations. In addition to corticosteroid therapy, micronutrient supplementation may serve as a useful complementary treatment approach.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-01-11
2026
2026-01-11
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/47270
url https://hdl.handle.net/10347/47270
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
© 2026 by the authors. Creative Commons Attribution (CC BY) license.
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
© 2026 by the authors. Creative Commons Attribution (CC BY) license.
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute MDPI
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute MDPI
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.228081

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