The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2)

SARS-CoV-2 infection; Corticosteroid therapy; Pre-existing heart disease

Detalles Bibliográficos
Autores: García-Onrubia, Jorge, Feltes, Gisela, Vazirani Ballesteros, Ravi, Sánchez del Hoyo, Rafael, Viana-Llamas, María C., RAPOSEIRAS-ROUBIN, SERGIO, Uribarri, Aitor
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:dnet:scientia____::edbb2e63bb0054fabd7522bcd28ea80b
Acceso en línea:http://hdl.handle.net/11351/14359
Access Level:acceso abierto
Palabra clave:COVID-19 (Malaltia) - Tractament
COVID-19 (Malaltia) - Prognosi
Corticosteroides - Ús terapèutic
Sistema cardiovascular - Malalties
CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones
Other subheadings::Other subheadings::/therapeutic use
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/drug therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
DISEASES::Cardiovascular Diseases
COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas de la corteza suprarrenal
Otros calificadores::Otros calificadores::/uso terapéutico
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
ENFERMEDADES::enfermedades cardiovasculares
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oai_identifier_str oai:dnet:scientia____::edbb2e63bb0054fabd7522bcd28ea80b
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2)
title The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2)
spellingShingle The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2)
García-Onrubia, Jorge
COVID-19 (Malaltia) - Tractament
COVID-19 (Malaltia) - Prognosi
Corticosteroides - Ús terapèutic
Sistema cardiovascular - Malalties
CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones
Other subheadings::Other subheadings::/therapeutic use
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/drug therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
DISEASES::Cardiovascular Diseases
COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas de la corteza suprarrenal
Otros calificadores::Otros calificadores::/uso terapéutico
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
ENFERMEDADES::enfermedades cardiovasculares
title_short The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2)
title_full The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2)
title_fullStr The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2)
title_full_unstemmed The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2)
title_sort The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2)
dc.creator.none.fl_str_mv García-Onrubia, Jorge
Feltes, Gisela
Vazirani Ballesteros, Ravi
Sánchez del Hoyo, Rafael
Viana-Llamas, María C.
RAPOSEIRAS-ROUBIN, SERGIO
Uribarri, Aitor
author García-Onrubia, Jorge
author_facet García-Onrubia, Jorge
Feltes, Gisela
Vazirani Ballesteros, Ravi
Sánchez del Hoyo, Rafael
Viana-Llamas, María C.
RAPOSEIRAS-ROUBIN, SERGIO
Uribarri, Aitor
author_role author
author2 Feltes, Gisela
Vazirani Ballesteros, Ravi
Sánchez del Hoyo, Rafael
Viana-Llamas, María C.
RAPOSEIRAS-ROUBIN, SERGIO
Uribarri, Aitor
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[García-Onrubia J, Vazirani R] Department of Cardiology, Cardiovascular Institute, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Feltes G] Cardiology Department, Hospital Vithas Arturo Soria, Madrid, Spain. Department of Cardiology, Hospital Universitario de Torrejón, Torrejón, Spain. Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain. [Sánchez-Del Hoyo R] Research Methodological Support Unit and Preventive Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Viana-Llamas MC] Cardiology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain. [Raposeiras-Roubín S] Cardiology Department, Hospital Universitario Álvaro Cunqueiro, Vigo, Spain. [Uribarri A] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv COVID-19 (Malaltia) - Tractament
COVID-19 (Malaltia) - Prognosi
Corticosteroides - Ús terapèutic
Sistema cardiovascular - Malalties
CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones
Other subheadings::Other subheadings::/therapeutic use
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/drug therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
DISEASES::Cardiovascular Diseases
COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas de la corteza suprarrenal
Otros calificadores::Otros calificadores::/uso terapéutico
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
ENFERMEDADES::enfermedades cardiovasculares
topic COVID-19 (Malaltia) - Tractament
COVID-19 (Malaltia) - Prognosi
Corticosteroides - Ús terapèutic
Sistema cardiovascular - Malalties
CHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones
Other subheadings::Other subheadings::/therapeutic use
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/drug therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
DISEASES::Cardiovascular Diseases
COMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas de la corteza suprarrenal
Otros calificadores::Otros calificadores::/uso terapéutico
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
ENFERMEDADES::enfermedades cardiovasculares
description SARS-CoV-2 infection; Corticosteroid therapy; Pre-existing heart disease
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11351/14359
url http://hdl.handle.net/11351/14359
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biomedicines;13(11)
https://doi.org/10.3390/biomedicines13112665
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421679136997376
spelling The Long-Term Outcomes of Corticosteroid Use in COVID-19 Patients with Cardiovascular Disease: A Propensity-Matched Analysis from the Multi-Center International Prospective Registry (HOPE-2)García-Onrubia, JorgeFeltes, GiselaVazirani Ballesteros, RaviSánchez del Hoyo, RafaelViana-Llamas, María C.RAPOSEIRAS-ROUBIN, SERGIOUribarri, AitorCOVID-19 (Malaltia) - TractamentCOVID-19 (Malaltia) - PrognosiCorticosteroides - Ús terapèuticSistema cardiovascular - MalaltiesCHEMICALS AND DRUGS::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex HormonesOther subheadings::Other subheadings::/therapeutic useDISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus InfectionsOther subheadings::Other subheadings::Other subheadings::/drug therapyANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::PrognosisDISEASES::Cardiovascular DiseasesCOMPUESTOS QUÍMICOS Y DROGAS::hormonas, sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas de la corteza suprarrenalOtros calificadores::Otros calificadores::/uso terapéuticoENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por CoronavirusOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronósticoENFERMEDADES::enfermedades cardiovascularesSARS-CoV-2 infection; Corticosteroid therapy; Pre-existing heart diseaseInfecció per SARS-CoV-2; Teràpia amb corticoesteroides; Malaltia cardíaca preexistentInfección por SARS-CoV-2; Terapia con corticoesteroides; Enfermedad cardíaca preexistenteIntroduction: Corticosteroid therapy has been demonstrated to improve prognosis and reduce mortality in patients with severe Coronavirus Disease 2019 (COVID-19) infection by attenuating the exaggerated inflammatory response that emerges in the late phase of infection. However, its impact on patients with pre-existing cardiovascular disease, who are at higher risk of complications, has not been specifically studied. The aim of this study is to evaluate the effect of corticosteroid therapy on mortality and long-term COVID-19 symptoms in this high-risk population. Methods: We analyzed the prospective registry HOPE-2. Patients with previous cardiovascular disease were selected, and 18-month all-cause death was defined as the primary endpoint. Long-term COVID-19 symptoms were considered as secondary endpoints. A total of 1188 patients with previous heart disease were included, of which 453 received corticosteroid treatment. Propensity score matching analysis in a 1:1 fashion was performed based on baseline variables that exhibited a p-value < 0.05 in the univariant analysis and outcome variables that defined corticosteroid use, with a final matched population of 796 patients. Results: In patients with pre-existing heart disease, corticosteroid treatment was not associated with differences in 18-month all-cause mortality (p = 0.52). However, a shorter duration of hospitalization (median: 8 days [IQR: 4–14] and 11 days [IQR: 7–18]; p < 0.001) was observed in patients who received corticosteroids. No significant differences in long-term COVID-19 symptoms were observed between the two groups. Conclusions: In patients with pre-existing heart disease, the absence of a clear harmful effect suggests that the positive effects of corticosteroids may be offset by their potential adverse effects which could contribute to the persistence of long COVID symptoms. This finding may reflect a differential response to corticosteroids in this high-risk subgroup, highlighting the need for further studies to clarify the role of this therapy in such patients.MDPIInstitut Català de la Salut[García-Onrubia J, Vazirani R] Department of Cardiology, Cardiovascular Institute, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Feltes G] Cardiology Department, Hospital Vithas Arturo Soria, Madrid, Spain. Department of Cardiology, Hospital Universitario de Torrejón, Torrejón, Spain. Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain. [Sánchez-Del Hoyo R] Research Methodological Support Unit and Preventive Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Viana-Llamas MC] Cardiology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain. [Raposeiras-Roubín S] Cardiology Department, Hospital Universitario Álvaro Cunqueiro, Vigo, Spain. [Uribarri A] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202620262025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/14359Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésBiomedicines;13(11)https://doi.org/10.3390/biomedicines13112665Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:scientia____::edbb2e63bb0054fabd7522bcd28ea80b2026-06-12T09:38:37Z
score 15,812455

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