The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control Study

The influence of different exposome factors on squamous cell carcinoma has been studied in several articles, although generally including a limited number of factors, especially chronic sun exposure. We carried out a prospective multicenter case-control study of patients with a history of squamous c...

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Autores: Navarro-Bielsa, Alba|||0000-0003-1171-6007, Gracia-Cazaña, Tamara|||0000-0002-0523-2076, Almagro Sánchez, Manuel|||0000-0002-3040-0705, De la Fuente-Meira, Sonia, Flórez, Ángeles|||0000-0001-9373-7826, Yélamos, Oriol|||0000-0002-8058-3095, Montero-Vilchez, Trinidad|||0000-0003-4035-7955, González Cruz, Carlos|||0000-0003-0117-8858, Diago, Adrián, Abadías-Granado, Isabel, Fuentelsaz, Victoria, Colmenero, María, Bañuls, José|||0000-0002-0990-7608, Arias-Santiago, Salvador|||0000-0002-4186-1435, Buendía-Eisman, Agustín, Almenara-Blasco, Manuel|||0000-0002-4350-401X, Gil-Pallares, Pedro|||0000-0001-8469-1942, Gilaberte, Yolanda|||0000-0001-8034-3617
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:291451
Acesso em linha:https://ddd.uab.cat/record/291451
https://dx.doi.org/urn:doi:10.3390/cancers15225376
Access Level:acceso abierto
Palavra-chave:Environmental exposure
Exposome
Diet
Squamous cell carcinoma
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oai_identifier_str oai:ddd.uab.cat:291451
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control Study
title The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control Study
spellingShingle The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control Study
Navarro-Bielsa, Alba|||0000-0003-1171-6007
Environmental exposure
Exposome
Diet
Squamous cell carcinoma
title_short The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control Study
title_full The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control Study
title_fullStr The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control Study
title_full_unstemmed The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control Study
title_sort The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control Study
dc.creator.none.fl_str_mv Navarro-Bielsa, Alba|||0000-0003-1171-6007
Gracia-Cazaña, Tamara|||0000-0002-0523-2076
Almagro Sánchez, Manuel|||0000-0002-3040-0705
De la Fuente-Meira, Sonia
Flórez, Ángeles|||0000-0001-9373-7826
Yélamos, Oriol|||0000-0002-8058-3095
Montero-Vilchez, Trinidad|||0000-0003-4035-7955
González Cruz, Carlos|||0000-0003-0117-8858
Diago, Adrián
Abadías-Granado, Isabel
Fuentelsaz, Victoria
Colmenero, María
Bañuls, José|||0000-0002-0990-7608
Arias-Santiago, Salvador|||0000-0002-4186-1435
Buendía-Eisman, Agustín
Almenara-Blasco, Manuel|||0000-0002-4350-401X
Gil-Pallares, Pedro|||0000-0001-8469-1942
Gilaberte, Yolanda|||0000-0001-8034-3617
author Navarro-Bielsa, Alba|||0000-0003-1171-6007
author_facet Navarro-Bielsa, Alba|||0000-0003-1171-6007
Gracia-Cazaña, Tamara|||0000-0002-0523-2076
Almagro Sánchez, Manuel|||0000-0002-3040-0705
De la Fuente-Meira, Sonia
Flórez, Ángeles|||0000-0001-9373-7826
Yélamos, Oriol|||0000-0002-8058-3095
Montero-Vilchez, Trinidad|||0000-0003-4035-7955
González Cruz, Carlos|||0000-0003-0117-8858
Diago, Adrián
Abadías-Granado, Isabel
Fuentelsaz, Victoria
Colmenero, María
Bañuls, José|||0000-0002-0990-7608
Arias-Santiago, Salvador|||0000-0002-4186-1435
Buendía-Eisman, Agustín
Almenara-Blasco, Manuel|||0000-0002-4350-401X
Gil-Pallares, Pedro|||0000-0001-8469-1942
Gilaberte, Yolanda|||0000-0001-8034-3617
author_role author
author2 Gracia-Cazaña, Tamara|||0000-0002-0523-2076
Almagro Sánchez, Manuel|||0000-0002-3040-0705
De la Fuente-Meira, Sonia
Flórez, Ángeles|||0000-0001-9373-7826
Yélamos, Oriol|||0000-0002-8058-3095
Montero-Vilchez, Trinidad|||0000-0003-4035-7955
González Cruz, Carlos|||0000-0003-0117-8858
Diago, Adrián
Abadías-Granado, Isabel
Fuentelsaz, Victoria
Colmenero, María
Bañuls, José|||0000-0002-0990-7608
Arias-Santiago, Salvador|||0000-0002-4186-1435
Buendía-Eisman, Agustín
Almenara-Blasco, Manuel|||0000-0002-4350-401X
Gil-Pallares, Pedro|||0000-0001-8469-1942
Gilaberte, Yolanda|||0000-0001-8034-3617
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Environmental exposure
Exposome
Diet
Squamous cell carcinoma
topic Environmental exposure
Exposome
Diet
Squamous cell carcinoma
description The influence of different exposome factors on squamous cell carcinoma has been studied in several articles, although generally including a limited number of factors, especially chronic sun exposure. We carried out a prospective multicenter case-control study of patients with a history of squamous cell carcinoma and a control group with no previous history of skin cancer, in which we compared most of the exposome variables, including sun exposure, photoprotection habits, diet, pollution, stress, and lifestyle. We found a significant association between squamous cell carcinoma and multiple exposome-related factors besides chronic sun exposure in the Spanish population. A better understanding of the actual impact of exposome in this condition could help design primary prevention strategies targeted at specific populations or risk behaviors. Introduction: The concept of exposome refers to the total of harmful and beneficial environmental exposures that can help predict the organism's biological responses over time. Ultraviolet radiation (UVR) from sun exposure has been recognized as the main etiological agent of skin cancer, and squamous cell carcinoma (SCC) is one most commonly associated with chronic exposure. However, in recent years, evidence suggests that lifestyle, environmental pollution, and contaminants in water and food can have an influence. Objectives: To study the relationship between SCC and sun exposure, pollution, stress, and lifestyle in a Spanish cohort. Materials and Method: A multicenter case-control study was carried out in which 13 dermatologists from different regions of Spain recruited cases and controls between April 2020 and August 2022. The group of cases were patients diagnosed with SCC and, as a control group, people who attended Dermatology consultations as companions with no history of skin cancer. Results: A total of 62 patients with SCC and 126 controls were included (62.9% males, median age 76.46 (10.1) and 33.3%, median age 55.7 (15), respectively). The SCC group had experienced more outside work than the controls (75% vs. 22.4%, p < 0.001), less recreational exposure (sunbathing, p = 0.05, and outdoor sports, p = 0.01), and a lower annual income (p = 0.01), with an increase in tobacco exposure (p < 0.001), without differences in other carcinogens, such as ionizing radiation or chemical exposure. The control group had a higher daily screentime use (p < 0.001) and practiced more relaxation activities (p = 0.03). A higher linolenic acid intake and lower coffee consumption were the only dietary variables associated with SCC (p < 0.05). Some chronic medications (anxiolytics, antidepressants, beta-blockers, statins, hydrochlorothiazide, ACE inhibitors, metformin, and omeprazole) were also statistically associated with SCC. Statistical significance for all aforementioned variables was maintained in the multivariate analysis (p < 0.05). Conclusions: The study found a significant association between SCC and multiple exposome-related factors in addition to chronic sun exposure in the Spanish population. Primary prevention strategies should target specific populations, such as outdoor workers promoting sun-safe behaviors and stress-reducing activities, in addition to adequate skin photoprotection in patients under certain medications associated with SCC.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/291451
https://dx.doi.org/urn:doi:10.3390/cancers15225376
url https://ddd.uab.cat/record/291451
https://dx.doi.org/urn:doi:10.3390/cancers15225376
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling The Influence of the Exposome in the Cutaneous Squamous Cell Carcinoma, a Multicenter Case-Control StudyNavarro-Bielsa, Alba|||0000-0003-1171-6007Gracia-Cazaña, Tamara|||0000-0002-0523-2076Almagro Sánchez, Manuel|||0000-0002-3040-0705De la Fuente-Meira, SoniaFlórez, Ángeles|||0000-0001-9373-7826Yélamos, Oriol|||0000-0002-8058-3095Montero-Vilchez, Trinidad|||0000-0003-4035-7955González Cruz, Carlos|||0000-0003-0117-8858Diago, AdriánAbadías-Granado, IsabelFuentelsaz, VictoriaColmenero, MaríaBañuls, José|||0000-0002-0990-7608Arias-Santiago, Salvador|||0000-0002-4186-1435Buendía-Eisman, AgustínAlmenara-Blasco, Manuel|||0000-0002-4350-401XGil-Pallares, Pedro|||0000-0001-8469-1942Gilaberte, Yolanda|||0000-0001-8034-3617Environmental exposureExposomeDietSquamous cell carcinomaThe influence of different exposome factors on squamous cell carcinoma has been studied in several articles, although generally including a limited number of factors, especially chronic sun exposure. We carried out a prospective multicenter case-control study of patients with a history of squamous cell carcinoma and a control group with no previous history of skin cancer, in which we compared most of the exposome variables, including sun exposure, photoprotection habits, diet, pollution, stress, and lifestyle. We found a significant association between squamous cell carcinoma and multiple exposome-related factors besides chronic sun exposure in the Spanish population. A better understanding of the actual impact of exposome in this condition could help design primary prevention strategies targeted at specific populations or risk behaviors. Introduction: The concept of exposome refers to the total of harmful and beneficial environmental exposures that can help predict the organism's biological responses over time. Ultraviolet radiation (UVR) from sun exposure has been recognized as the main etiological agent of skin cancer, and squamous cell carcinoma (SCC) is one most commonly associated with chronic exposure. However, in recent years, evidence suggests that lifestyle, environmental pollution, and contaminants in water and food can have an influence. Objectives: To study the relationship between SCC and sun exposure, pollution, stress, and lifestyle in a Spanish cohort. Materials and Method: A multicenter case-control study was carried out in which 13 dermatologists from different regions of Spain recruited cases and controls between April 2020 and August 2022. The group of cases were patients diagnosed with SCC and, as a control group, people who attended Dermatology consultations as companions with no history of skin cancer. Results: A total of 62 patients with SCC and 126 controls were included (62.9% males, median age 76.46 (10.1) and 33.3%, median age 55.7 (15), respectively). The SCC group had experienced more outside work than the controls (75% vs. 22.4%, p < 0.001), less recreational exposure (sunbathing, p = 0.05, and outdoor sports, p = 0.01), and a lower annual income (p = 0.01), with an increase in tobacco exposure (p < 0.001), without differences in other carcinogens, such as ionizing radiation or chemical exposure. The control group had a higher daily screentime use (p < 0.001) and practiced more relaxation activities (p = 0.03). A higher linolenic acid intake and lower coffee consumption were the only dietary variables associated with SCC (p < 0.05). Some chronic medications (anxiolytics, antidepressants, beta-blockers, statins, hydrochlorothiazide, ACE inhibitors, metformin, and omeprazole) were also statistically associated with SCC. Statistical significance for all aforementioned variables was maintained in the multivariate analysis (p < 0.05). Conclusions: The study found a significant association between SCC and multiple exposome-related factors in addition to chronic sun exposure in the Spanish population. Primary prevention strategies should target specific populations, such as outdoor workers promoting sun-safe behaviors and stress-reducing activities, in addition to adequate skin photoprotection in patients under certain medications associated with SCC.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/291451https://dx.doi.org/urn:doi:10.3390/cancers15225376reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2914512026-06-06T12:50:31Z
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