Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate
Chronic inflammation plays a significant role in the development and progression of metabolic dysfunction-related diseases. This study investigating a protein hydrolysate from Lupinus angustifolius (LPH) in mice model on a western diet (WD) aimed to elucidate its potential beneficial role in improvi...
| Autores: | , , , , , , , , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2025 |
| País: | España |
| Recursos: | Universidad de Castilla-La Mancha |
| Repositório: | RUIdeRA. Repositorio Institucional de la UCLM |
| OAI Identifier: | oai:ruidera.uclm.es:10578/46648 |
| Acesso em linha: | https://doi.org/10.1038/s41538-025-00515-7 https://hdl.handle.net/10578/46648 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Chronic inflammation Lupinus angustifolius (LPH) Sphingolipid metabolism |
| Resumo: | Chronic inflammation plays a significant role in the development and progression of metabolic dysfunction-related diseases. This study investigating a protein hydrolysate from Lupinus angustifolius (LPH) in mice model on a western diet (WD) aimed to elucidate its potential beneficial role in improving the lipidomic and anti-inflammatory profile. To achieve this objective, a lipidomic approach in combination with the evaluation of protein level modulation of selected key enzymes that are pivotal involved in the bioactive lipid pathway synthesis/regulation was performed on liver homogenates. Specifically, LPH positively impacted DHCer, SM, LacCer, Sph 1, DHSph 1, and S1P 1 concentrations, and restored the basal conditions of ASAH1 and ASM, proteins involved in sphingolipid metabolism. LPH also reduced the FASN and PPAR? levels and eicosanoids, with positive modulation of the COX-2 and ALOX5. Additionally, LPH reduced the WB-induced AEA and 2AG concentrations. |
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