Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
Background Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10256/22064 |
| Acceso en línea: | http://hdl.handle.net/10256/22064 |
| Access Level: | acceso abierto |
| Palabra clave: | Disbiosis Dysbiosis Obesitat Obesity Intestins -- Microbiologia Intestines -- Microbiology Hipotàlem Hypothalamus |
| id |
ES_da5dfe724b71737aa78cfbd6cf8cd4c5 |
|---|---|
| oai_identifier_str |
oai:recercat.cat:10256/22064 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance |
| title |
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance |
| spellingShingle |
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance Contreras-Rodríguez, Oren Disbiosis Dysbiosis Obesitat Obesity Intestins -- Microbiologia Intestines -- Microbiology Hipotàlem Hypothalamus |
| title_short |
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance |
| title_full |
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance |
| title_fullStr |
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance |
| title_full_unstemmed |
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance |
| title_sort |
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance |
| dc.creator.none.fl_str_mv |
Contreras-Rodríguez, Oren Arnoriaga Rodríguez, María Miranda-Olivos, R. Blasco Solà, Gerard Biarnés, Carles Puig Alcántara, Josep Rivera-Pinto, J. Calle, M.Luz Pérez Brocal, Vicente Moya, Andrés Coll-Martinez, Clàudia Ramió i Torrentà, Lluís Soriano-Mas, Carles Fernández-Real Lemos, José Manuel |
| author |
Contreras-Rodríguez, Oren |
| author_facet |
Contreras-Rodríguez, Oren Arnoriaga Rodríguez, María Miranda-Olivos, R. Blasco Solà, Gerard Biarnés, Carles Puig Alcántara, Josep Rivera-Pinto, J. Calle, M.Luz Pérez Brocal, Vicente Moya, Andrés Coll-Martinez, Clàudia Ramió i Torrentà, Lluís Soriano-Mas, Carles Fernández-Real Lemos, José Manuel |
| author_role |
author |
| author2 |
Arnoriaga Rodríguez, María Miranda-Olivos, R. Blasco Solà, Gerard Biarnés, Carles Puig Alcántara, Josep Rivera-Pinto, J. Calle, M.Luz Pérez Brocal, Vicente Moya, Andrés Coll-Martinez, Clàudia Ramió i Torrentà, Lluís Soriano-Mas, Carles Fernández-Real Lemos, José Manuel |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Disbiosis Dysbiosis Obesitat Obesity Intestins -- Microbiologia Intestines -- Microbiology Hipotàlem Hypothalamus |
| topic |
Disbiosis Dysbiosis Obesitat Obesity Intestins -- Microbiologia Intestines -- Microbiology Hipotàlem Hypothalamus |
| description |
Background Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms. Methods Medial (MH) and lateral (LH) hypothalamic structural covariance alterations were identified in 57 subjects with obesity compared to 47 subjects without obesity. Gut dysbiosis in the subjects with obesity was defined by the presence of high (n = 28) and low (n = 29) values in a BMI-associated microbial signature, and posthoc comparisons between these groups were used as a proxy to explore the role of obesity-related gut dysbiosis on the hypothalamic measurements, executive function, and depressive symptoms. Results Structural covariance alterations between the MH and the striatum, lateral prefrontal, cingulate, insula, and temporal cortices are congruent with previously functional connectivity disruptions in obesity conditions. MH structural covariance decreases encompassed postcentral parietal cortices in the subjects with obesity and gut-dysbiosis, but increases with subcortical nuclei involved in the coding food-related hedonic information in the subjects with obesity without gut-dysbiosis. Alterations for the structural covariance of the LH in the subjects with obesity and gut-dysbiosis encompassed increases with frontolimbic networks, but decreases with the lateral orbitofrontal cortex in the subjects with obesity without gut-dysbiosis. Subjects with obesity and gut dysbiosis showed higher executive dysfunction and depressive symptoms. Conclusions Obesity-related gut dysbiosis is linked to specific structural covariance alterations in hypothalamic networks relevant to the integration of somatic-visceral information, and emotion regulation |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion peer-reviewed |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10256/22064 |
| url |
http://hdl.handle.net/10256/22064 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41366-021-00953-9 info:eu-repo/semantics/altIdentifier/issn/0307-0565 info:eu-repo/semantics/altIdentifier/eissn/1476-5497 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Springer |
| publisher.none.fl_str_mv |
Springer |
| dc.source.none.fl_str_mv |
International Journal of Obesity, 2022, vol. 46, p. 30-38 Articles publicats (D-CM) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869421571173515264 |
| spelling |
Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covarianceContreras-Rodríguez, OrenArnoriaga Rodríguez, MaríaMiranda-Olivos, R.Blasco Solà, GerardBiarnés, CarlesPuig Alcántara, JosepRivera-Pinto, J.Calle, M.LuzPérez Brocal, VicenteMoya, AndrésColl-Martinez, ClàudiaRamió i Torrentà, LluísSoriano-Mas, CarlesFernández-Real Lemos, José ManuelDisbiosisDysbiosisObesitatObesityIntestins -- MicrobiologiaIntestines -- MicrobiologyHipotàlemHypothalamusBackground Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms. Methods Medial (MH) and lateral (LH) hypothalamic structural covariance alterations were identified in 57 subjects with obesity compared to 47 subjects without obesity. Gut dysbiosis in the subjects with obesity was defined by the presence of high (n = 28) and low (n = 29) values in a BMI-associated microbial signature, and posthoc comparisons between these groups were used as a proxy to explore the role of obesity-related gut dysbiosis on the hypothalamic measurements, executive function, and depressive symptoms. Results Structural covariance alterations between the MH and the striatum, lateral prefrontal, cingulate, insula, and temporal cortices are congruent with previously functional connectivity disruptions in obesity conditions. MH structural covariance decreases encompassed postcentral parietal cortices in the subjects with obesity and gut-dysbiosis, but increases with subcortical nuclei involved in the coding food-related hedonic information in the subjects with obesity without gut-dysbiosis. Alterations for the structural covariance of the LH in the subjects with obesity and gut-dysbiosis encompassed increases with frontolimbic networks, but decreases with the lateral orbitofrontal cortex in the subjects with obesity without gut-dysbiosis. Subjects with obesity and gut dysbiosis showed higher executive dysfunction and depressive symptoms. Conclusions Obesity-related gut dysbiosis is linked to specific structural covariance alterations in hypothalamic networks relevant to the integration of somatic-visceral information, and emotion regulationThis study has been funded by the Project Grant IRONMET (PI15/01934) from the ISCIII, and the Project ThinkGut (EFA345/19) 65% co-financed by the European Regional Development Fund (ERDF) through the Interreg V-A Spain-France-Andorra program (POCTEFA 2014–2020) (JM Fernández-Real). Partial support was also obtained by the Ministerio de Economia y Competitividad, Spain, reference MTM2015-64465-C2-1-R (ML Calle). O Contreras-Rodriguez is funded by a “PERIS” postdoctoral fellowship (SLT006/17/00236) from the Health Department of the Catalan Government and by a “Miguel Servet” contract (CP20/00165) from the ISCIII. M Arnoriaga-Rodríguez is funded by a predoctoral Rio Hortega contract (CM19/00190) co-funded by European Social Fund “Investigating in your future” from the ISCIIISpringer2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/22064International Journal of Obesity, 2022, vol. 46, p. 30-38Articles publicats (D-CM)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41366-021-00953-9info:eu-repo/semantics/altIdentifier/issn/0307-0565info:eu-repo/semantics/altIdentifier/eissn/1476-5497Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/220642026-05-29T05:05:01Z |
| score |
15.228081 |