Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts

Pleopeltis crassinervata is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently, conducting biological and pharmacological assays is crucial to validate the therapeutic efficacy of this plant within the con...

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Autores: Anacleto-Santos, Jhony, Vega-Ávila, Elisa, Pacheco, Leticia, Lacueva-Arnedo, Manuel, Gómez Barrio, Alicia, Ibáñez Escribano, Alexandra, López-Pérez, Teresa de Jesús, Casarrubias-Tabarez, Brenda, Calzada, Fernando, López-Camacho, Perla Yolanda, Rivera-Fernández, Norma
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/104299
Acceso en línea:https://hdl.handle.net/20.500.14352/104299
Access Level:acceso abierto
Palabra clave:579.6
615.28
576.8
traditional medicine
antibacterial activity
trichomonacidal effect
Pleopeltis crassinervata
Ciencias Biomédicas
Microbiología (Farmacia)
Parasitología (Farmacia)
3209 Farmacología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/104299
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network_name_str España
repository_id_str
spelling Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata ExtractsAnacleto-Santos, JhonyVega-Ávila, ElisaPacheco, LeticiaLacueva-Arnedo, ManuelGómez Barrio, AliciaIbáñez Escribano, AlexandraLópez-Pérez, Teresa de JesúsCasarrubias-Tabarez, BrendaCalzada, FernandoLópez-Camacho, Perla YolandaRivera-Fernández, Norma579.6615.28576.8traditional medicineantibacterial activitytrichomonacidal effectPleopeltis crassinervataCiencias BiomédicasMicrobiología (Farmacia)Parasitología (Farmacia)3209 FarmacologíaPleopeltis crassinervata is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently, conducting biological and pharmacological assays is crucial to validate the therapeutic efficacy of this plant within the context of traditional medicine. In the present study, we investigated the biological activity of extracts and fractions obtained from P. crassinervata organs against bacteria (Salmonella typhimurium, Salmonella typhi, Staphylococcus aureus, Proteus mirabilis, Shigella flexneri, Bacillus subtilis, Escherichia coli) and Trichomonas vaginalis using in vitro models. The precipitate fraction obtained from the frond methanolic extract showed significant antibacterial activity (minimal inhibitory concentration [MIC] 120 µg/mL) against the Staphylococcus aureus strain and was effective against both Gram-positive and Gram-negative bacteria. The hexane fraction also obtained from frond methanolic extract, showed a trichomonacidal effect with an IC50 of 82.8 μg/mL and a low cytotoxic effect. Hsf6 exhibited the highest activity against T. vaginalis, and the GC-MS analysis revealed that the predominant compound was 16-pregnenolone. The remaining identified compounds were primarily terpene-type compounds.MDPIUniversidad Complutense de Madrid20242024-05-0720242024-05-07journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/104299reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1042992026-06-02T12:44:21Z
dc.title.none.fl_str_mv Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts
title Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts
spellingShingle Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts
Anacleto-Santos, Jhony
579.6
615.28
576.8
traditional medicine
antibacterial activity
trichomonacidal effect
Pleopeltis crassinervata
Ciencias Biomédicas
Microbiología (Farmacia)
Parasitología (Farmacia)
3209 Farmacología
title_short Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts
title_full Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts
title_fullStr Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts
title_full_unstemmed Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts
title_sort Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts
dc.creator.none.fl_str_mv Anacleto-Santos, Jhony
Vega-Ávila, Elisa
Pacheco, Leticia
Lacueva-Arnedo, Manuel
Gómez Barrio, Alicia
Ibáñez Escribano, Alexandra
López-Pérez, Teresa de Jesús
Casarrubias-Tabarez, Brenda
Calzada, Fernando
López-Camacho, Perla Yolanda
Rivera-Fernández, Norma
author Anacleto-Santos, Jhony
author_facet Anacleto-Santos, Jhony
Vega-Ávila, Elisa
Pacheco, Leticia
Lacueva-Arnedo, Manuel
Gómez Barrio, Alicia
Ibáñez Escribano, Alexandra
López-Pérez, Teresa de Jesús
Casarrubias-Tabarez, Brenda
Calzada, Fernando
López-Camacho, Perla Yolanda
Rivera-Fernández, Norma
author_role author
author2 Vega-Ávila, Elisa
Pacheco, Leticia
Lacueva-Arnedo, Manuel
Gómez Barrio, Alicia
Ibáñez Escribano, Alexandra
López-Pérez, Teresa de Jesús
Casarrubias-Tabarez, Brenda
Calzada, Fernando
López-Camacho, Perla Yolanda
Rivera-Fernández, Norma
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 579.6
615.28
576.8
traditional medicine
antibacterial activity
trichomonacidal effect
Pleopeltis crassinervata
Ciencias Biomédicas
Microbiología (Farmacia)
Parasitología (Farmacia)
3209 Farmacología
topic 579.6
615.28
576.8
traditional medicine
antibacterial activity
trichomonacidal effect
Pleopeltis crassinervata
Ciencias Biomédicas
Microbiología (Farmacia)
Parasitología (Farmacia)
3209 Farmacología
description Pleopeltis crassinervata is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently, conducting biological and pharmacological assays is crucial to validate the therapeutic efficacy of this plant within the context of traditional medicine. In the present study, we investigated the biological activity of extracts and fractions obtained from P. crassinervata organs against bacteria (Salmonella typhimurium, Salmonella typhi, Staphylococcus aureus, Proteus mirabilis, Shigella flexneri, Bacillus subtilis, Escherichia coli) and Trichomonas vaginalis using in vitro models. The precipitate fraction obtained from the frond methanolic extract showed significant antibacterial activity (minimal inhibitory concentration [MIC] 120 µg/mL) against the Staphylococcus aureus strain and was effective against both Gram-positive and Gram-negative bacteria. The hexane fraction also obtained from frond methanolic extract, showed a trichomonacidal effect with an IC50 of 82.8 μg/mL and a low cytotoxic effect. Hsf6 exhibited the highest activity against T. vaginalis, and the GC-MS analysis revealed that the predominant compound was 16-pregnenolone. The remaining identified compounds were primarily terpene-type compounds.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-05-07
2024
2024-05-07
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/104299
url https://hdl.handle.net/20.500.14352/104299
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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