Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study.
BACKGROUND: Previous cross-sectional studies report that cognitive impairment is associated with poor psychosocial functioning in euthymic bipolar patients. There is a lack of long-term studies to determine the course of cognitive impairment and its impact on functional outcome. Method A total of 54...
| Autores: | , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2012 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositório: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/53643 |
| Acesso em linha: | https://hdl.handle.net/2445/53643 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Trastorn bipolar Liti Trastorns de la cognició Manic-depressive illness Lithium Cognition disorders |
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Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study.Mora, EsterPortella Moll, María JesúsForcada, IreneVieta i Pascual, Eduard, 1963-Mur, MariaTrastorn bipolarLitiTrastorns de la cognicióManic-depressive illnessLithiumCognition disordersBACKGROUND: Previous cross-sectional studies report that cognitive impairment is associated with poor psychosocial functioning in euthymic bipolar patients. There is a lack of long-term studies to determine the course of cognitive impairment and its impact on functional outcome. Method A total of 54 subjects were assessed at baseline and 6 years later; 28 had DSM-IV TR bipolar I or II disorder (recruited, at baseline, from a Lithium Clinic Program) and 26 were healthy matched controls. They were all assessed with a cognitive battery tapping into the main cognitive domains (executive function, attention, processing speed, verbal memory and visual memory) twice over a 6-year follow-up period. All patients were euthymic (Hamilton Rating Scale for Depression score lower than 8 and Young mania rating scale score lower than 6) for at least 3 months before both evaluations. At the end of follow-up, psychosocial functioning was also evaluated by means of the Functioning Assessment Short Test. RESULTS: Repeated-measures multivariate analysis of covariance showed that there were main effects of group in the executive domain, in the inhibition domain, in the processing speed domain, and in the verbal memory domain (p<0.04). Among the clinical factors, only longer illness duration was significantly related to slow processing (p=0.01), whereas strong relationships were observed between impoverished cognition along time and poorer psychosocial functioning (p<0.05). CONCLUSIONS: Executive functioning, inhibition, processing speed and verbal memory were impaired in euthymic bipolar out-patients. Although cognitive deficits remained stable on average throughout the follow-up, they had enduring negative effects on psychosocial adaptation of patients.Cambridge University Press2014201420122014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/53643Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1017/S0033291712001948Psychological Medicine, 2012, vol. 43, num. 6, p. 1187-1196http://dx.doi.org/10.1017/S0033291712001948(c) Cambridge University Press, 2012info:eu-repo/semantics/openAccessoai:recercat.cat:2445/536432026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study. |
| title |
Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study. |
| spellingShingle |
Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study. Mora, Ester Trastorn bipolar Liti Trastorns de la cognició Manic-depressive illness Lithium Cognition disorders |
| title_short |
Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study. |
| title_full |
Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study. |
| title_fullStr |
Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study. |
| title_full_unstemmed |
Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study. |
| title_sort |
Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study. |
| dc.creator.none.fl_str_mv |
Mora, Ester Portella Moll, María Jesús Forcada, Irene Vieta i Pascual, Eduard, 1963- Mur, Maria |
| author |
Mora, Ester |
| author_facet |
Mora, Ester Portella Moll, María Jesús Forcada, Irene Vieta i Pascual, Eduard, 1963- Mur, Maria |
| author_role |
author |
| author2 |
Portella Moll, María Jesús Forcada, Irene Vieta i Pascual, Eduard, 1963- Mur, Maria |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Trastorn bipolar Liti Trastorns de la cognició Manic-depressive illness Lithium Cognition disorders |
| topic |
Trastorn bipolar Liti Trastorns de la cognició Manic-depressive illness Lithium Cognition disorders |
| description |
BACKGROUND: Previous cross-sectional studies report that cognitive impairment is associated with poor psychosocial functioning in euthymic bipolar patients. There is a lack of long-term studies to determine the course of cognitive impairment and its impact on functional outcome. Method A total of 54 subjects were assessed at baseline and 6 years later; 28 had DSM-IV TR bipolar I or II disorder (recruited, at baseline, from a Lithium Clinic Program) and 26 were healthy matched controls. They were all assessed with a cognitive battery tapping into the main cognitive domains (executive function, attention, processing speed, verbal memory and visual memory) twice over a 6-year follow-up period. All patients were euthymic (Hamilton Rating Scale for Depression score lower than 8 and Young mania rating scale score lower than 6) for at least 3 months before both evaluations. At the end of follow-up, psychosocial functioning was also evaluated by means of the Functioning Assessment Short Test. RESULTS: Repeated-measures multivariate analysis of covariance showed that there were main effects of group in the executive domain, in the inhibition domain, in the processing speed domain, and in the verbal memory domain (p<0.04). Among the clinical factors, only longer illness duration was significantly related to slow processing (p=0.01), whereas strong relationships were observed between impoverished cognition along time and poorer psychosocial functioning (p<0.05). CONCLUSIONS: Executive functioning, inhibition, processing speed and verbal memory were impaired in euthymic bipolar out-patients. Although cognitive deficits remained stable on average throughout the follow-up, they had enduring negative effects on psychosocial adaptation of patients. |
| publishDate |
2012 |
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2012 2014 2014 2014 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/53643 |
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https://hdl.handle.net/2445/53643 |
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Inglés |
| language_invalid_str_mv |
Inglés |
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Reproducció del document publicat a: http://dx.doi.org/10.1017/S0033291712001948 Psychological Medicine, 2012, vol. 43, num. 6, p. 1187-1196 http://dx.doi.org/10.1017/S0033291712001948 |
| dc.rights.none.fl_str_mv |
(c) Cambridge University Press, 2012 info:eu-repo/semantics/openAccess |
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(c) Cambridge University Press, 2012 |
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openAccess |
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10 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Cambridge University Press |
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Cambridge University Press |
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Articles publicats en revistes (Psicologia Clínica i Psicobiologia) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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