Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease

Introduction: The aim of the study is to describe the frequency of frailty in people with a new diagnosis of mild dementia due to Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Methods: This is a secondary analysis of the Dementia Study of Western Norway (Demvest). For this study, we...

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Authors: Borda-Borda, M.G. (Miguel German)|||/items/681ecdf1-0f23-4003-a702-417198fd228d, Soennesyn, H. (Hogne)|||/items/64ddd66b-47c3-478d-9106-124368eb5a55, Steves, C.J. (Claire J.)|||/items/487baec7-6786-4748-8aa7-c7b968fd427a, Osland-Vik-Mo, A. (Audun)|||/items/4e6b29b0-f646-4ddc-96e9-a4571c89f787, Pérez-Zepeda, M.U. (Mario Ulises)|||/items/fd0c6e2f-d3fe-4434-9b2d-156fc1f553e8, Aarsland, D. (Dag)|||/items/7f4024e7-2d11-43cf-8b41-29752ddf75e1
Format: article
Publication Date:2019
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/121623
Online Access:https://hdl.handle.net/10171/121623
Access Level:Open access
Keyword:frequency of frailty
mild dementia
Alzheimer’s disease
dementia with Lewy bodies
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spelling Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s DiseaseBorda-Borda, M.G. (Miguel German)|||/items/681ecdf1-0f23-4003-a702-417198fd228dSoennesyn, H. (Hogne)|||/items/64ddd66b-47c3-478d-9106-124368eb5a55Steves, C.J. (Claire J.)|||/items/487baec7-6786-4748-8aa7-c7b968fd427aOsland-Vik-Mo, A. (Audun)|||/items/4e6b29b0-f646-4ddc-96e9-a4571c89f787Pérez-Zepeda, M.U. (Mario Ulises)|||/items/fd0c6e2f-d3fe-4434-9b2d-156fc1f553e8Aarsland, D. (Dag)|||/items/7f4024e7-2d11-43cf-8b41-29752ddf75e1frequency of frailtymild dementiaAlzheimer’s diseasedementia with Lewy bodiesIntroduction: The aim of the study is to describe the frequency of frailty in people with a new diagnosis of mild dementia due to Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Methods: This is a secondary analysis of the Dementia Study of Western Norway (Demvest). For this study, we analysed a sample of 186 patients, 116 with AD and 70 with DLB. Subjects were included at a time in which mild dementia was diagnosed according to consensus criteria after comprehensive standardized assessment. Frailty was evaluated retrospectively using a frailty index generated from existing data. The cut-off value used to classify an older adult as frail was 0.25. Results: The prevalence of frailty was 25.81% (n = 48). In the DLB group, 37.14% (n = 26) were classified as frail, compared to 18.97% (n = 22) of those with AD (p < 0.001). The adjusted multivariate analysis revealed an OR of 2.45 (1.15–5.23) for being frail in those with DLB when using AD as the reference group. Conclusion: Frailty was higher than expected in both types of dementia. The prevalence of frailty was higher in those with DLB compared to AD. This new finding underscores the need for a multi-systems approach in both dementias, with a particular focus on DLB.KargerDadun. Depósito Académico Digital Universidad de Navarra20192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/121623reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1216232026-06-21T12:47:57Z
dc.title.none.fl_str_mv Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease
title Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease
spellingShingle Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease
Borda-Borda, M.G. (Miguel German)|||/items/681ecdf1-0f23-4003-a702-417198fd228d
frequency of frailty
mild dementia
Alzheimer’s disease
dementia with Lewy bodies
title_short Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease
title_full Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease
title_fullStr Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease
title_full_unstemmed Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease
title_sort Frailty in Older Adults with Mild Dementia: Dementia with Lewy Bodies and Alzheimer’s Disease
dc.creator.none.fl_str_mv Borda-Borda, M.G. (Miguel German)|||/items/681ecdf1-0f23-4003-a702-417198fd228d
Soennesyn, H. (Hogne)|||/items/64ddd66b-47c3-478d-9106-124368eb5a55
Steves, C.J. (Claire J.)|||/items/487baec7-6786-4748-8aa7-c7b968fd427a
Osland-Vik-Mo, A. (Audun)|||/items/4e6b29b0-f646-4ddc-96e9-a4571c89f787
Pérez-Zepeda, M.U. (Mario Ulises)|||/items/fd0c6e2f-d3fe-4434-9b2d-156fc1f553e8
Aarsland, D. (Dag)|||/items/7f4024e7-2d11-43cf-8b41-29752ddf75e1
author Borda-Borda, M.G. (Miguel German)|||/items/681ecdf1-0f23-4003-a702-417198fd228d
author_facet Borda-Borda, M.G. (Miguel German)|||/items/681ecdf1-0f23-4003-a702-417198fd228d
Soennesyn, H. (Hogne)|||/items/64ddd66b-47c3-478d-9106-124368eb5a55
Steves, C.J. (Claire J.)|||/items/487baec7-6786-4748-8aa7-c7b968fd427a
Osland-Vik-Mo, A. (Audun)|||/items/4e6b29b0-f646-4ddc-96e9-a4571c89f787
Pérez-Zepeda, M.U. (Mario Ulises)|||/items/fd0c6e2f-d3fe-4434-9b2d-156fc1f553e8
Aarsland, D. (Dag)|||/items/7f4024e7-2d11-43cf-8b41-29752ddf75e1
author_role author
author2 Soennesyn, H. (Hogne)|||/items/64ddd66b-47c3-478d-9106-124368eb5a55
Steves, C.J. (Claire J.)|||/items/487baec7-6786-4748-8aa7-c7b968fd427a
Osland-Vik-Mo, A. (Audun)|||/items/4e6b29b0-f646-4ddc-96e9-a4571c89f787
Pérez-Zepeda, M.U. (Mario Ulises)|||/items/fd0c6e2f-d3fe-4434-9b2d-156fc1f553e8
Aarsland, D. (Dag)|||/items/7f4024e7-2d11-43cf-8b41-29752ddf75e1
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv frequency of frailty
mild dementia
Alzheimer’s disease
dementia with Lewy bodies
topic frequency of frailty
mild dementia
Alzheimer’s disease
dementia with Lewy bodies
description Introduction: The aim of the study is to describe the frequency of frailty in people with a new diagnosis of mild dementia due to Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). Methods: This is a secondary analysis of the Dementia Study of Western Norway (Demvest). For this study, we analysed a sample of 186 patients, 116 with AD and 70 with DLB. Subjects were included at a time in which mild dementia was diagnosed according to consensus criteria after comprehensive standardized assessment. Frailty was evaluated retrospectively using a frailty index generated from existing data. The cut-off value used to classify an older adult as frail was 0.25. Results: The prevalence of frailty was 25.81% (n = 48). In the DLB group, 37.14% (n = 26) were classified as frail, compared to 18.97% (n = 22) of those with AD (p < 0.001). The adjusted multivariate analysis revealed an OR of 2.45 (1.15–5.23) for being frail in those with DLB when using AD as the reference group. Conclusion: Frailty was higher than expected in both types of dementia. The prevalence of frailty was higher in those with DLB compared to AD. This new finding underscores the need for a multi-systems approach in both dementias, with a particular focus on DLB.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/121623
url https://hdl.handle.net/10171/121623
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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