NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations

Current models for the study of neuroendocrine tumours (NETs) are severely limited. While in vitro (e.g. cell lines), ex vivo (e.g. organoids) and in vivo (e.g. mice) models all exist, each has limitations. To address these limitations and collectively identify strategies to move the NET models fiel...

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Bibliographic Details
Authors: Ear, Po Hie, Marinoni, Ilaria, Dayton, Talya, Guenter, Rachael, Dawn, E Quelle, Battistella, Anna, Buishand, Floryne O, Chittaranjan, Suganthi, Du, Yi-Cheih Nancy, Marqués, Inés, Pellegata, Natalia S, Sadowski, Samira M, Tirosh, Amit, April-Monn, Simon, Aurilia, Cinzia, Jaskula-Sztul, Renata, Baena Moreno, Maria Jesús, Donati, Simone, English, Katherine A, Hernández Llorens, María Almudena, Hodgetts, Harry, Marini, Francesca, Martins, Maria, Palmini, Gaia, Soldevilla Navarro, Beatriz, Schrader, Jörg, Thakker, Rajesh V, Lines, Kate E
Format: article
Publication Date:2024
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/118378
Online Access:https://hdl.handle.net/20.500.14352/118378
Access Level:Open access
Keyword:612.4
616-006
Consortium
Ex vivo
In vitro
In vivo
Endocrinología
Oncología
Genética
Fisiología
2411.04 Fisiología Endocrina
3205.08 Enfermedades Pulmonares
Description
Summary:Current models for the study of neuroendocrine tumours (NETs) are severely limited. While in vitro (e.g. cell lines), ex vivo (e.g. organoids) and in vivo (e.g. mice) models all exist, each has limitations. To address these limitations and collectively identify strategies to move the NET models field forward, we held an inaugural NET models meeting, hosted by our founding group: Dr Lines (Oxford), Prof. Quelle (Iowa), Dr Dayton (Barcelona), Dr Ear (Iowa), Dr Marinoni (Bern) and Dr Guenter (Alabama). This two-day meeting in Oxford (UK) was organised and supported by Bioscientifica Ltd and was solely dedicated to the discussion of NET models. The meeting was attended by ∼30 international researchers (from the UK, EU, Israel, USA and Canada). Plenary talks were given by Prof. Thakker, who summarised NET research over the past few decades, and Dr Schrader, who described the process and pitfalls of generating new cell lines. Eight researchers also presented their work on topics ranging from human cell 3D bioprinting to zebrafish models and included novel ideas and improvements on current concepts. This was followed by an interactive workshop, where discussion topics included a summary of currently available NET models, limitations of these models, barriers to developing new models, and how we can address these issues going forward. This white paper summarises the key points raised in these discussions and the future aspirations of the NET Models Consortium. The next meeting will take place in Oxford (UK) in 2025; contact contact@netcancerfoundation.com for more information.

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