Association between the use of short-acting bronchodilators and the risk of hospitalization for asthma in a real-life clinical practice population cohort

Objective: To determine the number of short-acting beta-agonists (SABA) canisters dispensed in a pharmacy during one year that is associated with higher asthma hospitalization risk in the same period in patients with active asthma. Multi-centre cross-sectional descriptive design. Location: Primary c...

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Autores: Sorribas Morlan, Monica, Galmes Garau, Miguel Angel, Esteva Cantó, Magdalena, Leiva, Alfonso, Román-Rodríguez, Miguel
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:español
OAI Identifier:oai:docusalut.com:20.500.13003/17232
Acceso en línea:https://hdl.handle.net/20.500.13003/17232
Access Level:acceso abierto
Palabra clave:Asthma
Treatment
Bronchodilators
Hospitalization
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spelling Association between the use of short-acting bronchodilators and the risk of hospitalization for asthma in a real-life clinical practice population cohortSorribas Morlan, MonicaGalmes Garau, Miguel AngelEsteva Cantó, MagdalenaLeiva, AlfonsoRomán-Rodríguez, MiguelAsthmaTreatmentBronchodilatorsHospitalizationObjective: To determine the number of short-acting beta-agonists (SABA) canisters dispensed in a pharmacy during one year that is associated with higher asthma hospitalization risk in the same period in patients with active asthma. Multi-centre cross-sectional descriptive design. Location: Primary care, MAJORICA cohort including sociodemographic, clinical and electronic prescription system data coded during clinical practice from 68,578 patients with COPD and asthma in the Balearic Islands. Participants: A total of 7,648 patients older than 18 years with active asthma, who got any SABA canister from the pharmacy during the 2014-2015 period were included. COPD patients were excluded. Main measurements: Asthma hospitalization, respiratory medication, tobacco, co-morbidities, age and gender. Results: Mean age 47 years, 38% women, 23.2% active smokers. Seventy-seven patients (1%) were admitted for asthma exacerbation in the study period. Patients who received more than 8 SABA containers per year increased the risk of hospitalization (OR 2.81; 95% CI 1.27-6.24). Severity by therapeutic step and amount of inhaled corticosteroids, as well as heart failure and sleep apnea were also significantly associated with hospitalization. Conclusions: There is a significant association between the risk of hospitalization and the higher number of SABA canisters dispensed from the pharmacy. The number of canisters/year that best defines a higher risk of hospitalization is >= 8 and could be used to identify asthma at risk.Ediciones Doyma SA20202020-11-0120202020-11-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/17232reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsEspañolspaopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/172322026-06-22T12:44:07Z
dc.title.none.fl_str_mv Association between the use of short-acting bronchodilators and the risk of hospitalization for asthma in a real-life clinical practice population cohort
title Association between the use of short-acting bronchodilators and the risk of hospitalization for asthma in a real-life clinical practice population cohort
spellingShingle Association between the use of short-acting bronchodilators and the risk of hospitalization for asthma in a real-life clinical practice population cohort
Sorribas Morlan, Monica
Asthma
Treatment
Bronchodilators
Hospitalization
title_short Association between the use of short-acting bronchodilators and the risk of hospitalization for asthma in a real-life clinical practice population cohort
title_full Association between the use of short-acting bronchodilators and the risk of hospitalization for asthma in a real-life clinical practice population cohort
title_fullStr Association between the use of short-acting bronchodilators and the risk of hospitalization for asthma in a real-life clinical practice population cohort
title_full_unstemmed Association between the use of short-acting bronchodilators and the risk of hospitalization for asthma in a real-life clinical practice population cohort
title_sort Association between the use of short-acting bronchodilators and the risk of hospitalization for asthma in a real-life clinical practice population cohort
dc.creator.none.fl_str_mv Sorribas Morlan, Monica
Galmes Garau, Miguel Angel
Esteva Cantó, Magdalena
Leiva, Alfonso
Román-Rodríguez, Miguel
author Sorribas Morlan, Monica
author_facet Sorribas Morlan, Monica
Galmes Garau, Miguel Angel
Esteva Cantó, Magdalena
Leiva, Alfonso
Román-Rodríguez, Miguel
author_role author
author2 Galmes Garau, Miguel Angel
Esteva Cantó, Magdalena
Leiva, Alfonso
Román-Rodríguez, Miguel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Asthma
Treatment
Bronchodilators
Hospitalization
topic Asthma
Treatment
Bronchodilators
Hospitalization
description Objective: To determine the number of short-acting beta-agonists (SABA) canisters dispensed in a pharmacy during one year that is associated with higher asthma hospitalization risk in the same period in patients with active asthma. Multi-centre cross-sectional descriptive design. Location: Primary care, MAJORICA cohort including sociodemographic, clinical and electronic prescription system data coded during clinical practice from 68,578 patients with COPD and asthma in the Balearic Islands. Participants: A total of 7,648 patients older than 18 years with active asthma, who got any SABA canister from the pharmacy during the 2014-2015 period were included. COPD patients were excluded. Main measurements: Asthma hospitalization, respiratory medication, tobacco, co-morbidities, age and gender. Results: Mean age 47 years, 38% women, 23.2% active smokers. Seventy-seven patients (1%) were admitted for asthma exacerbation in the study period. Patients who received more than 8 SABA containers per year increased the risk of hospitalization (OR 2.81; 95% CI 1.27-6.24). Severity by therapeutic step and amount of inhaled corticosteroids, as well as heart failure and sleep apnea were also significantly associated with hospitalization. Conclusions: There is a significant association between the risk of hospitalization and the higher number of SABA canisters dispensed from the pharmacy. The number of canisters/year that best defines a higher risk of hospitalization is >= 8 and could be used to identify asthma at risk.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-11-01
2020
2020-11-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/17232
url https://hdl.handle.net/20.500.13003/17232
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ediciones Doyma SA
publisher.none.fl_str_mv Ediciones Doyma SA
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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