Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies

Tauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of hyperphosphorylated tau in neurons and glia. Primary tauopathies are not uncommon in humans but exceptional in other species. We evaluate the clinical, neuropathological, and genetic alterations re...

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Autores: Vidal-Palencia, Laura, Font, Cristina, Rebollada-Merino, Agustín, Santpere Baró, Gabriel, 1981-, Andrés Benito, Pol, Ferrer, Isidre, Pumarola, Martí
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/59900
Acceso en línea:http://hdl.handle.net/10230/59900
http://dx.doi.org/10.3390/ani13182985
Access Level:acceso abierto
Palabra clave:Cat
Neurodegenerative disease
Tau
Tauopathy
Veterinary neuropathology
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spelling Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studiesVidal-Palencia, LauraFont, CristinaRebollada-Merino, AgustínSantpere Baró, Gabriel, 1981-Andrés Benito, PolFerrer, IsidrePumarola, MartíCatNeurodegenerative diseaseTauTauopathyVeterinary neuropathologyTauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of hyperphosphorylated tau in neurons and glia. Primary tauopathies are not uncommon in humans but exceptional in other species. We evaluate the clinical, neuropathological, and genetic alterations related to tau pathology in 16 cats aged from 1 to 21 years with different clinical backgrounds. Interestingly, a 10-year-old female cat presented a six-year progressive history of mental status and gait abnormalities. The imaging study revealed generalized cortical atrophy. Due to the poor prognosis, the cat was euthanatized at the age of ten. Neuropathological lesions were characterized by massive neuronal loss with marked spongiosis and associated moderate reactive gliosis in the parietal cortex, being less severe in other areas of the cerebral cortex, and the loss of Purkinje cells of the cerebellum. Immunohistochemical methods revealed a 4R-tauopathy with granular pre-tangles in neurons and coiled bodies in oligodendrocytes. Deposits were recognized with several phospho-site antibodies (4Rtau, tau5, AT8, PFH, tau-P Thr181, tau-P-Ser 262, tau-P Ser 422) and associated with increased granular expression of active tau kinases (p38-P Thr180/Tyr182 and SAPK/JNK-P Thr138/Thr185). The genetic study revealed well-preserved coding regions of MAPT. No similar alterations related to tau pathology were found in the other 15 cats processed in parallel. To our knowledge, this is the first case reporting a primary 4R-tauopathy with severe cerebral and Purkinje cell degeneration in an adult cat with neurological signs starting at a young age.L.V.-P. is supported by an FI predoctoral fellowship (2023 FI-3 00034) from the Generalitat de Catalunya (AGAUR). G.S. is supported by Instituto de Salud Carlos III Spain and European Social Fund grant MS20/00064; grant PID2019-104700GA-I00 funded by /AEI/10.13039/501100011033; grant 202230-30 from Fundació La Marató de TV3; and National Institutes of Health grant R01HG010898-01. I.F. and P.A-B are funded by “la Caixa” Foundation (ID 100010434) under the agreement LCF/PR/ HR19/52160007, HR18–00452.MDPI202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/59900http://dx.doi.org/10.3390/ani13182985reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésAnimals (Basel). 2023 Sep 21;13(18):2985info:eu-repo/grantAgreement/ES/2PE/PID2019-104700GA-I00© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/599002026-06-12T07:21:37Z
dc.title.none.fl_str_mv Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies
title Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies
spellingShingle Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies
Vidal-Palencia, Laura
Cat
Neurodegenerative disease
Tau
Tauopathy
Veterinary neuropathology
title_short Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies
title_full Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies
title_fullStr Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies
title_full_unstemmed Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies
title_sort Primary feline tauopathy: clinical, morphological, immunohistochemical, and genetic studies
dc.creator.none.fl_str_mv Vidal-Palencia, Laura
Font, Cristina
Rebollada-Merino, Agustín
Santpere Baró, Gabriel, 1981-
Andrés Benito, Pol
Ferrer, Isidre
Pumarola, Martí
author Vidal-Palencia, Laura
author_facet Vidal-Palencia, Laura
Font, Cristina
Rebollada-Merino, Agustín
Santpere Baró, Gabriel, 1981-
Andrés Benito, Pol
Ferrer, Isidre
Pumarola, Martí
author_role author
author2 Font, Cristina
Rebollada-Merino, Agustín
Santpere Baró, Gabriel, 1981-
Andrés Benito, Pol
Ferrer, Isidre
Pumarola, Martí
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cat
Neurodegenerative disease
Tau
Tauopathy
Veterinary neuropathology
topic Cat
Neurodegenerative disease
Tau
Tauopathy
Veterinary neuropathology
description Tauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of hyperphosphorylated tau in neurons and glia. Primary tauopathies are not uncommon in humans but exceptional in other species. We evaluate the clinical, neuropathological, and genetic alterations related to tau pathology in 16 cats aged from 1 to 21 years with different clinical backgrounds. Interestingly, a 10-year-old female cat presented a six-year progressive history of mental status and gait abnormalities. The imaging study revealed generalized cortical atrophy. Due to the poor prognosis, the cat was euthanatized at the age of ten. Neuropathological lesions were characterized by massive neuronal loss with marked spongiosis and associated moderate reactive gliosis in the parietal cortex, being less severe in other areas of the cerebral cortex, and the loss of Purkinje cells of the cerebellum. Immunohistochemical methods revealed a 4R-tauopathy with granular pre-tangles in neurons and coiled bodies in oligodendrocytes. Deposits were recognized with several phospho-site antibodies (4Rtau, tau5, AT8, PFH, tau-P Thr181, tau-P-Ser 262, tau-P Ser 422) and associated with increased granular expression of active tau kinases (p38-P Thr180/Tyr182 and SAPK/JNK-P Thr138/Thr185). The genetic study revealed well-preserved coding regions of MAPT. No similar alterations related to tau pathology were found in the other 15 cats processed in parallel. To our knowledge, this is the first case reporting a primary 4R-tauopathy with severe cerebral and Purkinje cell degeneration in an adult cat with neurological signs starting at a young age.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/59900
http://dx.doi.org/10.3390/ani13182985
url http://hdl.handle.net/10230/59900
http://dx.doi.org/10.3390/ani13182985
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Animals (Basel). 2023 Sep 21;13(18):2985
info:eu-repo/grantAgreement/ES/2PE/PID2019-104700GA-I00
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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