Nocturnal blood pressure patterns in pediatric obstructive sleep apnea: The Kids Trial study

Obstructive sleep apnea (OSA) in children is associated with cardiovascular risk, but its impact on sleep blood pressure (BP) remains incompletely understood. Objective: To assess the association between the severity of OSA, stratified by the obstructive apnea-hypopnea index (OAHI), and altered slee...

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Detalles Bibliográficos
Autores: Mediano, Olga, Castillo-García, María, Romero-Peralta, Sofía, Viejo-Ayuso, María Esther, Silgado-Martínez, Laura, Álvarez-Balado, Leticia, Forné Izquierdo, Carles, Resano-Barrio, Pilar, García-Rio, Francisco, Cano-Pumarega, Irene, Sánchez-de-la-Torre, Manuel, Ortigado, Alfonso, Fidalgo, Laura, Rodríguez, Ángel, López-Monzoni, Sonia, Álvarez, Ainhoa, Pía-Martínez, Carla, Del Río, Genoveva, Bragado, Esther, Roncero, Alejandra, García-Mediano, Belén, Mato-López, Álvaro, Rodríguez-Perojo, Adriana, Pengo, Martino F, Solano-Pérez, Esther
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:dnet:.___________::46281ec2c279c994c18e462813575715
Acceso en línea:https://doi.org/10.1016/j.sleep.2026.108957
https://hdl.handle.net/10459.1/470077
Access Level:acceso abierto
Palabra clave:Ambulatory blood pressure monitoring
Cardiovascular risk factors
Children
Non-dipping pattern
Obstructive sleep apnea
Descripción
Sumario:Obstructive sleep apnea (OSA) in children is associated with cardiovascular risk, but its impact on sleep blood pressure (BP) remains incompletely understood. Objective: To assess the association between the severity of OSA, stratified by the obstructive apnea-hypopnea index (OAHI), and altered sleep BP patterns, specifically the non-dipping pattern (NDP), using ambulatory 24-h BP monitoring (ABPM). Methods: The Kids-Trial is a multicenter observational trial (NCT03696654) conducted in Spain, including children with suspected OSA that underwent polysomnography for its diagnosis. To estimate the impact of OAHI on the risk of NDP, a multivariable logistic regression model was constructed and odds ratio (OR) was calculated. Results: A total of 267 children were included (median age of 6 years and 42.7 % girls). When BP was assessed through z-score, significant positive trends were observed according to OSA severity in 24-h mean BP, 24-h systolic BP, sleep mean BP, sleep systolic BP, sleep diastolic BP, and NDP. A negative trend was observed for the drop in sleep mean BP. The adjusted model showed that severe OSA was independently associated with a reduced drop in mean BP (-3.68 (-6.9; -0.47); p = 0.026). Adjusted multivariable analysis of NDP showed an increased but not significant risk of NDP in severe OSA vs. non-OSA (OR = 2.76 (0.92, 8.30)). Conclusion: Severe pediatric OSA was independently associated with disrupted nocturnal BP regulation, including a reduced BP dipping. These findings underscore the importance of ABPM in pediatric sleep evaluations.

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