Biocompatibility and bone regeneration with elastin-like recombinamer-based catalyst-free click gels

[EN]Large bone defects are a significant health problem today with various origins, including extensive trauma, tumours, or congenital musculoskeletal disorders. Tissue engineering, and in particular bone tissue engineering, aims to respond to this demand. As such, we propose a specific model based...

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Bibliographic Details
Authors: Camal Ruggieri, I N, Aimone, M, Juanes-Gusano, D, Ibáñez-Fonseca, A, Santiago, O, Stur, M, Mardegan Issa, J P, Missana, L R, Alonso, M, Rodríguez-Cabello, J C, Feldman, S
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Universidad de Salamanca (USAL)
Repository:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/169465
Online Access:http://hdl.handle.net/10366/169465
Access Level:Open access
Keyword:Bone
Elastin
Scaffold
Tissue engineering
Hydrogels
Tissue Engineering
Animals
Tissue Scaffolds
Rabbits
Bone Regeneration
Click Chemistry
Biocompatible Materials
regeneración ósea
materiales biocompatibles
animales
armazones tisulares
química clic
conejos
ingeniería tisular
elastina
hidrogeles
Description
Summary:[EN]Large bone defects are a significant health problem today with various origins, including extensive trauma, tumours, or congenital musculoskeletal disorders. Tissue engineering, and in particular bone tissue engineering, aims to respond to this demand. As such, we propose a specific model based on Elastin-Like Recombinamers-based click-chemistry hydrogels given their high biocompatibility and their potent on bone regeneration effect conferred by different bioactive sequences. In this work we demonstrate, using biochemistry, histology, histomorphometry and imaging techniques, the biocompatibility of our matrix and its potent effect on bone regeneration in a model of bone parietal lesion in female New Zealand rabbits.

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