Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond

Background Cognitive impairment (CI) significantly impacts the quality of life of glioma patients. The main contributing risk factors include tumor characteristics, treatment-related factors, and their complex interplay. This review explores the role of advanced structural neuroimaging techniques in...

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Autores: Cayuela, Nuria, Izquierdo, Cristina, Vaquero, Lucía, Càmara, Estela, Bruna, Jordi, Simó, Marta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/220318
Acceso en línea:https://hdl.handle.net/2445/220318
Access Level:acceso abierto
Palabra clave:Glioma
Imatges per ressonància magnètica
Trastorns de la cognició
Gliomas
Magnetic resonance imaging
Cognition disorders
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spelling Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyondCayuela, NuriaIzquierdo, CristinaVaquero, LucíaCàmara, EstelaBruna, JordiSimó, MartaGliomaImatges per ressonància magnèticaTrastorns de la cognicióGliomasMagnetic resonance imagingCognition disordersBackground Cognitive impairment (CI) significantly impacts the quality of life of glioma patients. The main contributing risk factors include tumor characteristics, treatment-related factors, and their complex interplay. This review explores the role of advanced structural neuroimaging techniques in understanding CI in glioma patients.Methods A literature search was conducted in PubMed, PsycINFO, and ISI Web of Knowledge using specific keywords. We included studies with advanced magnetic resonance imaging techniques and objective neuropsychological exams.Results At diagnosis, during the pre-surgery phase, associations between glioma characteristics and cognitive outcomes have been described. Specifically, patients with isocitrate dehydrogenase (IDH)-wild-type gliomas exhibit more adverse cognitive outcomes, accompanied by disruptions in gray (GM) and white matter (WM) networks when compared to IDH-mutant. In addition, pre- and post-surgery imaging analyses highlight the importance of preserving specific WM tracts, such as the inferior longitudinal and arcuate fasciculus, in mitigating verbal memory and language processing decline. Furthermore, examining gliomas in perisylvian regions emphasizes deleterious effects on various cognitive domains. Additionally, it has been suggested that neuroplastic reorganization could serve as a compensatory mechanism against CI. Lastly, a limited number of studies suggest long-term CI linked to GM atrophy and leukoencephalopathy induced by radiotherapy +/- chemotherapy in glioma survivors, highlighting the need for improving treatment approaches, particularly for patients with extended survival expectations.Conclusion This review underscores the need for nuanced understanding and an individual approach in the management of glioma patients. Neuroplastic insights offer clinicians valuable guidance in surgical decision-making and personalized therapeutic approaches thus improving patient outcomes in neuro-oncology.Oxford University Press (OUP)2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion20 p.application/pdfhttps://hdl.handle.net/2445/220318Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1093/noajnl/vdaf003Neuro-Oncology Advances, 2025, vol. 7, num. 1https://doi.org/10.1093/noajnl/vdaf003cc-by-nc (c) Cayuela, Nuria et al., 2025http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2203182026-05-29T05:05:01Z
dc.title.none.fl_str_mv Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond
title Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond
spellingShingle Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond
Cayuela, Nuria
Glioma
Imatges per ressonància magnètica
Trastorns de la cognició
Gliomas
Magnetic resonance imaging
Cognition disorders
title_short Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond
title_full Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond
title_fullStr Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond
title_full_unstemmed Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond
title_sort Mapping glioma’s impact on cognition: Insights from macrostructure, microstructure, and beyond
dc.creator.none.fl_str_mv Cayuela, Nuria
Izquierdo, Cristina
Vaquero, Lucía
Càmara, Estela
Bruna, Jordi
Simó, Marta
author Cayuela, Nuria
author_facet Cayuela, Nuria
Izquierdo, Cristina
Vaquero, Lucía
Càmara, Estela
Bruna, Jordi
Simó, Marta
author_role author
author2 Izquierdo, Cristina
Vaquero, Lucía
Càmara, Estela
Bruna, Jordi
Simó, Marta
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Glioma
Imatges per ressonància magnètica
Trastorns de la cognició
Gliomas
Magnetic resonance imaging
Cognition disorders
topic Glioma
Imatges per ressonància magnètica
Trastorns de la cognició
Gliomas
Magnetic resonance imaging
Cognition disorders
description Background Cognitive impairment (CI) significantly impacts the quality of life of glioma patients. The main contributing risk factors include tumor characteristics, treatment-related factors, and their complex interplay. This review explores the role of advanced structural neuroimaging techniques in understanding CI in glioma patients.Methods A literature search was conducted in PubMed, PsycINFO, and ISI Web of Knowledge using specific keywords. We included studies with advanced magnetic resonance imaging techniques and objective neuropsychological exams.Results At diagnosis, during the pre-surgery phase, associations between glioma characteristics and cognitive outcomes have been described. Specifically, patients with isocitrate dehydrogenase (IDH)-wild-type gliomas exhibit more adverse cognitive outcomes, accompanied by disruptions in gray (GM) and white matter (WM) networks when compared to IDH-mutant. In addition, pre- and post-surgery imaging analyses highlight the importance of preserving specific WM tracts, such as the inferior longitudinal and arcuate fasciculus, in mitigating verbal memory and language processing decline. Furthermore, examining gliomas in perisylvian regions emphasizes deleterious effects on various cognitive domains. Additionally, it has been suggested that neuroplastic reorganization could serve as a compensatory mechanism against CI. Lastly, a limited number of studies suggest long-term CI linked to GM atrophy and leukoencephalopathy induced by radiotherapy +/- chemotherapy in glioma survivors, highlighting the need for improving treatment approaches, particularly for patients with extended survival expectations.Conclusion This review underscores the need for nuanced understanding and an individual approach in the management of glioma patients. Neuroplastic insights offer clinicians valuable guidance in surgical decision-making and personalized therapeutic approaches thus improving patient outcomes in neuro-oncology.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/220318
url https://hdl.handle.net/2445/220318
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1093/noajnl/vdaf003
Neuro-Oncology Advances, 2025, vol. 7, num. 1
https://doi.org/10.1093/noajnl/vdaf003
dc.rights.none.fl_str_mv cc-by-nc (c) Cayuela, Nuria et al., 2025
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Cayuela, Nuria et al., 2025
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 20 p.
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press (OUP)
publisher.none.fl_str_mv Oxford University Press (OUP)
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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