Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling

Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study the differe...

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Autores: Jobst, Beatrice M., Hindriks, Rikkert, Laufs, Helmut, Tagliazucchi, Enzo, Hahn, Gerald, Ponce Álvarez, Adrián Fernando|||0000-0003-1446-7392, Stevner, Angus B.A., Kringelbach, Morten L., Deco, Gustavo
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/401710
Acceso en línea:https://hdl.handle.net/2117/401710
https://dx.doi.org/10.1038/s41598-017-04522-x
Access Level:acceso abierto
Palabra clave:Neurology
Brain -- Research
Neurologia
Cervell -- Investigació
Classificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Neurologia
Àrees temàtiques de la UPC::Enginyeria biomèdica
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repository_id_str
spelling Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modellingJobst, Beatrice M.Hindriks, RikkertLaufs, HelmutTagliazucchi, EnzoHahn, GeraldPonce Álvarez, Adrián Fernando|||0000-0003-1446-7392Stevner, Angus B.A.Kringelbach, Morten L.Deco, GustavoNeurologyBrain -- ResearchNeurologiaCervell -- InvestigacióClassificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topicsÀrees temàtiques de la UPC::Ciències de la salut::Medicina::NeurologiaÀrees temàtiques de la UPC::Enginyeria biomèdicaRecent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study the differences in global brain functional connectivity and synchrony of fMRI activity in healthy humans during wakefulness and slow-wave sleep. We applied a whole-brain model based on the normal form of a supercritical Hopf bifurcation and studied the dynamical changes when adapting the bifurcation parameter for all brain nodes to best match wakefulness and slow-wave sleep. Furthermore, we analysed differences in effective connectivity between the two states. In addition to significant changes in functional connectivity, synchrony and metastability, this analysis revealed a significant shift of the global dynamic working point of brain dynamics, from the edge of the transition between damped to sustained oscillations during wakefulness, to a stable focus during slow-wave sleep. Moreover, we identified a significant global decrease in effective interactions during slow-wave sleep. These results suggest a mechanism for the empirical functional changes observed during slow-wave sleep, namely a global shift of the brain’s dynamic working point leading to increased stability and decreased effective connectivity.BMJ, RH, GH, APA and GD were funded by the European Research Council (ERC) Advanced Grant DYSTRUCTURE (n. 295129), European Union’s Horizon 2020 research and innovation programme under grant agreement No. 720270 (HBP SGA1) and No. 661583 (CONSBRAIN), by the Programa Estatal de Investigación Cientifica y Tecnica de Excelencia MINECO (PSI2013-42091, PSI2016-75688-P (AEI/FEDER, EU) and PCIN-2013-026), Juan de la Cierva fellowship (IJCI-2014-21066) and by the Catalan Agency for Management of University and Research Grants, AGAUR (2014SGR856). ET and HL were supported by the Bundesministerium für Bildung und Forschung (grantnumber 01 EV 0703) and the LOEWE Neuronale Koordination Forschungsschwerpunkt Frankfurt (NeFF). ET was further funded by a postdoctoral grant of the AXA foundation. MLK was supported by the ERC Consolidator Grant CAREGIVING (n. 615539).Peer ReviewedSpringer Nature20172017-07-0520242024-02-12journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/401710https://dx.doi.org/10.1038/s41598-017-04522-xreponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4017102026-05-27T15:37:01Z
dc.title.none.fl_str_mv Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
title Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
spellingShingle Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
Jobst, Beatrice M.
Neurology
Brain -- Research
Neurologia
Cervell -- Investigació
Classificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Neurologia
Àrees temàtiques de la UPC::Enginyeria biomèdica
title_short Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
title_full Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
title_fullStr Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
title_full_unstemmed Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
title_sort Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
dc.creator.none.fl_str_mv Jobst, Beatrice M.
Hindriks, Rikkert
Laufs, Helmut
Tagliazucchi, Enzo
Hahn, Gerald
Ponce Álvarez, Adrián Fernando|||0000-0003-1446-7392
Stevner, Angus B.A.
Kringelbach, Morten L.
Deco, Gustavo
author Jobst, Beatrice M.
author_facet Jobst, Beatrice M.
Hindriks, Rikkert
Laufs, Helmut
Tagliazucchi, Enzo
Hahn, Gerald
Ponce Álvarez, Adrián Fernando|||0000-0003-1446-7392
Stevner, Angus B.A.
Kringelbach, Morten L.
Deco, Gustavo
author_role author
author2 Hindriks, Rikkert
Laufs, Helmut
Tagliazucchi, Enzo
Hahn, Gerald
Ponce Álvarez, Adrián Fernando|||0000-0003-1446-7392
Stevner, Angus B.A.
Kringelbach, Morten L.
Deco, Gustavo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurology
Brain -- Research
Neurologia
Cervell -- Investigació
Classificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Neurologia
Àrees temàtiques de la UPC::Enginyeria biomèdica
topic Neurology
Brain -- Research
Neurologia
Cervell -- Investigació
Classificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Neurologia
Àrees temàtiques de la UPC::Enginyeria biomèdica
description Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study the differences in global brain functional connectivity and synchrony of fMRI activity in healthy humans during wakefulness and slow-wave sleep. We applied a whole-brain model based on the normal form of a supercritical Hopf bifurcation and studied the dynamical changes when adapting the bifurcation parameter for all brain nodes to best match wakefulness and slow-wave sleep. Furthermore, we analysed differences in effective connectivity between the two states. In addition to significant changes in functional connectivity, synchrony and metastability, this analysis revealed a significant shift of the global dynamic working point of brain dynamics, from the edge of the transition between damped to sustained oscillations during wakefulness, to a stable focus during slow-wave sleep. Moreover, we identified a significant global decrease in effective interactions during slow-wave sleep. These results suggest a mechanism for the empirical functional changes observed during slow-wave sleep, namely a global shift of the brain’s dynamic working point leading to increased stability and decreased effective connectivity.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-07-05
2024
2024-02-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/401710
https://dx.doi.org/10.1038/s41598-017-04522-x
url https://hdl.handle.net/2117/401710
https://dx.doi.org/10.1038/s41598-017-04522-x
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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