Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scores

Cancer; Mortality; Nutrition

Detalhes bibliográficos
Autores: UYAR, Galip Can, BAŞKURT, KADRİYE, YEŞİLBAŞ, ENES, Recuero-Borau, Jordi, Vega, kreina, Pedrola Gómez, Anna, Serradell, Sonia, Mirallas, Oriol, Martin-Cullell, Berta, Gomez-Puerto, Diego, Salva de Torres, Clara, Dienstmann, Rodrigo, Navarro Garces, Victor
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/13287
Acesso em linha:http://hdl.handle.net/11351/13287
Access Level:acceso abierto
Palavra-chave:Càncer - Mortalitat
Càncer - Prognosi
Hospitals - Ingressos i altes
DISEASES::Neoplasms
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::Hospitalization
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::hospitalización
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oai_identifier_str oai:recercat.cat:11351/13287
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scores
title Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scores
spellingShingle Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scores
UYAR, Galip Can
Càncer - Mortalitat
Càncer - Prognosi
Hospitals - Ingressos i altes
DISEASES::Neoplasms
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::Hospitalization
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::hospitalización
title_short Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scores
title_full Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scores
title_fullStr Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scores
title_full_unstemmed Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scores
title_sort Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scores
dc.creator.none.fl_str_mv UYAR, Galip Can
BAŞKURT, KADRİYE
YEŞİLBAŞ, ENES
Recuero-Borau, Jordi
Vega, kreina
Pedrola Gómez, Anna
Serradell, Sonia
Mirallas, Oriol
Martin-Cullell, Berta
Gomez-Puerto, Diego
Salva de Torres, Clara
Dienstmann, Rodrigo
Navarro Garces, Victor
author UYAR, Galip Can
author_facet UYAR, Galip Can
BAŞKURT, KADRİYE
YEŞİLBAŞ, ENES
Recuero-Borau, Jordi
Vega, kreina
Pedrola Gómez, Anna
Serradell, Sonia
Mirallas, Oriol
Martin-Cullell, Berta
Gomez-Puerto, Diego
Salva de Torres, Clara
Dienstmann, Rodrigo
Navarro Garces, Victor
author_role author
author2 BAŞKURT, KADRİYE
YEŞİLBAŞ, ENES
Recuero-Borau, Jordi
Vega, kreina
Pedrola Gómez, Anna
Serradell, Sonia
Mirallas, Oriol
Martin-Cullell, Berta
Gomez-Puerto, Diego
Salva de Torres, Clara
Dienstmann, Rodrigo
Navarro Garces, Victor
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Uyar GC, Başkurt K, Yeşilbaş E] Medical Oncology Department, Etlik City Hospital, Ankara, Turkey. [Mirallas O, Vega Cano KS, Gómez-Puerto D, Salva de Torres C, Serradell S] Departament d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Martin-Cullell B] Medical Oncology Department, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain. [Recuero-Borau J] Medical Oncology Department, Hospital del Mar, Barcelona, Spain. [Navarro Garcés V, Pedrola Gómez A, Dienstmann R] Oncology Data Science (ODysSey) Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Càncer - Mortalitat
Càncer - Prognosi
Hospitals - Ingressos i altes
DISEASES::Neoplasms
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::Hospitalization
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::hospitalización
topic Càncer - Mortalitat
Càncer - Prognosi
Hospitals - Ingressos i altes
DISEASES::Neoplasms
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::Hospitalization
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::hospitalización
description Cancer; Mortality; Nutrition
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11351/13287
url http://hdl.handle.net/11351/13287
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The Lancet Regional Health - Europe;54
https://doi.org/10.1016/j.lanepe.2025.101317
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420334829010944
spelling Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scoresUYAR, Galip CanBAŞKURT, KADRİYEYEŞİLBAŞ, ENESRecuero-Borau, JordiVega, kreinaPedrola Gómez, AnnaSerradell, SoniaMirallas, OriolMartin-Cullell, BertaGomez-Puerto, DiegoSalva de Torres, ClaraDienstmann, RodrigoNavarro Garces, VictorCàncer - MortalitatCàncer - PrognosiHospitals - Ingressos i altesDISEASES::NeoplasmsOther subheadings::Other subheadings::Other subheadings::Other subheadings::/mortalityANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::PrognosisANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::HospitalizationENFERMEDADES::neoplasiasOtros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidadTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronósticoTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::hospitalizaciónCancer; Mortality; NutritionCàncer; Mortalitat; NutricióCáncer; Mortalidad; NutriciónBackground Accurate prediction of 90-day mortality in hospitalised cancer patients is critical for guiding personalised treatment decisions and optimising oncologic care. However, existing prognostic models often lack sufficient precision, particularly in distinguishing between high- and low-risk patients. In this retrospective study, we independently evaluated the prognostic performance of three scoring systems—the Prognostic Score for Hospitalised Cancer Patients (PROMISE), the Gustave Roussy Immune (GRIm) score, and the C-reactive protein–Triglyceride–Glucose Index (CTI)—in patients admitted for unplanned hospitalisations. Methods This retrospective observational study was conducted at the Medical Oncology Clinic of Ankara Etlik City Hospital, Turkey, and included patients aged 18 years or older with a diagnosis of cancer who were hospitalised unexpectedly between February 2023 and February 2024. Laboratory data were retrieved from the institutional hospital information system. The PROMISE score was calculated using its original specification via the online tool (https://promise.vhio.net/). The GRIm score was calculated based on neutrophil-to-lymphocyte ratio (NLR), albumin, and lactate dehydrogenase (LDH). The CTI score was computed as: CTI = [0.412 × ln (C-reactive protein [CRP])] + ln [Triglyceride × Glucose/2], with a cut-off value of 4.78. A PROMISE–CTI Combined score was derived using regression-based weighting. Risk stratification was performed for all three scores using validated thresholds. Statistical analyses included Kaplan–Meier survival analysis, log-rank tests, univariable and multivariable logistic regression to assess predictors of 90-day mortality, and receiver operating characteristic (ROC) curve analysis to evaluate discriminatory performance. Findings Among 1657 hospitalised cancer patients screened during the study period, 1109 met the inclusion criteria and were included in the analysis. PROMISE and GRIm scores were calculated for all 1109 patients, while CTI score was assessed in 333 patients with complete laboratory data. The 90-day mortality rate was 63.7% (n = 707). High PROMISE score (OR: 3.32, 95% CI: 1.40–7.86; p = 0.006) and high CTI score (OR: 2.85, 95% CI: 1.32–6.18; p = 0.008) were associated with increased 90-day mortality. Low PROMISE score (OR: 0.22, 95% CI: 0.10–0.49; p = 0.001) and low CTI score (OR: 0.35, 95% CI: 0.17–0.73; p = 0.003) were associated with reduced 90-day mortality. High GRIm score (OR: 1.83, 95% CI: 0.83–2.91; p = 0.07) and low GRIm score (OR: 0.73, 95% CI: 0.47–1.20; p = 0.08) were not significantly associated with 90-day mortality. The area under the curve (AUC) of the PROMISE–CTI Combined score was 0.884 (95% CI: 0.849–0.919; p < 0.0001). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of the PROMISE–CTI Combined score were 92.4%, 81.1%, 85.3%, 89.6%, and 86.7%, respectively. Interpretation The PROMISE score demonstrated strong discriminatory ability in predicting 90-day mortality among cancer patients admitted for unplanned hospitalisations. Integration of the CTI score further improved risk stratification by incorporating nutritional and inflammatory markers. The PROMISE–CTI Combined score may serve as a practical clinical tool for short-term prognostic assessment in this setting. Prospective, multicentre, randomised studies are needed to confirm the clinical utility and generalisability of the PROMISE–CTI Combined score.ElsevierInstitut Català de la Salut[Uyar GC, Başkurt K, Yeşilbaş E] Medical Oncology Department, Etlik City Hospital, Ankara, Turkey. [Mirallas O, Vega Cano KS, Gómez-Puerto D, Salva de Torres C, Serradell S] Departament d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Martin-Cullell B] Medical Oncology Department, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain. [Recuero-Borau J] Medical Oncology Department, Hospital del Mar, Barcelona, Spain. [Navarro Garcés V, Pedrola Gómez A, Dienstmann R] Oncology Data Science (ODysSey) Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/13287Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésThe Lancet Regional Health - Europe;54https://doi.org/10.1016/j.lanepe.2025.101317Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/132872026-05-29T05:05:01Z
score 15,198674

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