Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study

A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist i...

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Detalles Bibliográficos
Autores: Sánchez, Enric|||0000-0001-7345-1601, Kerkeni, Mohsen|||0000-0001-5594-7451, Hernández García, Marta|||0000-0003-1237-298X, Gavaldà, Ricard, Rius Riu, Ferran|||0000-0002-0916-957X, Sauret, Ariadna, Torres, Gerard|||0000-0002-1417-7320, Bermúdez-López, Marcelino|||0000-0002-3188-4158, Fernández, Elvira|||0000-0001-5236-1762, Castro-Boqué, Eva|||0000-0002-1013-0007, Purroy, Francisco|||0000-0002-1808-5968, Mauricio, Didac|||0000-0002-2868-0250, Farràs-Sallés, Cristina|||0000-0001-5956-4116, Buti, Miquel, Godoy, Pere|||0000-0002-2896-7286, Pamplona, Reinald|||0000-0003-4337-6107, Lecube, Albert|||0000-0001-9684-0183
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:290555
Acceso en línea:https://ddd.uab.cat/record/290555
https://dx.doi.org/urn:doi:10.3390/nu14051102
Access Level:acceso abierto
Palabra clave:Advanced glycation end-products
Glycosylated hemoglobin
Prediabetes
Skin autofluorescence
Descripción
Sumario:A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist in the diagnosis of prediabetes is unclear. A cross-sectional study was conducted in 4181 middle-aged subjects without diabetes. Prediabetes (n = 1444) was defined as a glycosylated hemoglobin (HbA1c) level between 39 and 47 mmol/mol (5.7 to 6.4%), and skin autofluorescence (SAF) measurement was performed to assess AGEs. A multivariable logistic regression model and receiver operating characteristic curve were used. The cohort consisted of 50.1% women with an age of 57 [52;62] years, a BMI of 28.3 [25.4;31.6] kg/m, and a prevalence of prediabetes of 34.5%. Participants with prediabetes showed higher SAF than control participants (2.0 [1.7;2.2] vs. 1.9 [1.7;2.2], p < 0.001). However, HbA1c was not significantly correlated with SAF levels (r = 0.026, p = 0.090). In addition, the SAF level was not independently associated with prediabetes (OR = 1.12 (0.96 to 1.30)). Finally, there was no good cutoff point for SAF to identify patients with prediabetes (AUC = 0.52 (0.50 to 0.54), sensitivity = 0.61, and 1-specificity = 0.56). Given all of this evidence, we can conclude that although there is an increase in SAF levels in participants with prediabetes, the applicability and clinical relevance of the results is low in this population.

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