Untangling the biological effects of cerium oxide nanoparticles: The role of surface valence states

Cerium oxide nanoparticles (nanoceria; CNPs) have been found to have both pro-oxidant and antioxidant effects on different cell systems or organisms. In order to untangle the mechanisms which underlie the biological activity of nanoceria, we have studied the effect of five different CNPs on a model...

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Autores: Pulido Reyes, Gerardo, Rodea-Palomares, Ismael, Das, Soumen, Sakthivel, Tamil Selvan, Leganés Nieto, Francisco, Rosal, Roberto, Seal, Sudipta, Fernández Piñas, Francisca
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/672888
Acesso em linha:http://hdl.handle.net/10486/672888
https://dx.doi.org/10.1038/srep15613
Access Level:acceso abierto
Palavra-chave:Cerium oxide nanoparticles
Cell systems
Aquatic microorganism
Toxicity
Biología y Biomedicina / Biología
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spelling Untangling the biological effects of cerium oxide nanoparticles: The role of surface valence statesPulido Reyes, GerardoRodea-Palomares, IsmaelDas, SoumenSakthivel, Tamil SelvanLeganés Nieto, FranciscoRosal, RobertoSeal, SudiptaFernández Piñas, FranciscaCerium oxide nanoparticlesCell systemsAquatic microorganismToxicityBiología y Biomedicina / BiologíaCerium oxide nanoparticles (nanoceria; CNPs) have been found to have both pro-oxidant and antioxidant effects on different cell systems or organisms. In order to untangle the mechanisms which underlie the biological activity of nanoceria, we have studied the effect of five different CNPs on a model relevant aquatic microorganism. Neither shape, concentration, synthesis method, surface charge (ζ-potential), nor nominal size had any influence in the observed biological activity. The main driver of toxicity was found to be the percentage of surface content of Ce3+ sites: CNP1 (58%) and CNP5 (40%) were found to be toxic whereas CNP2 (28%), CNP3 (36%) and CNP4 (26%) were found to be non-toxic. The colloidal stability and redox chemistry of the most and least toxic CNPs, CNP1 and CNP2, respectively, were modified by incubation with iron and phosphate buffers. Blocking surface Ce3+ sites of the most toxic CNP, CNP1, with phosphate treatment reverted toxicity and stimulated growth. Colloidal destabilization with Fe treatment only increased toxicity of CNP1. The results of this study are relevant in the understanding of the main drivers of biological activity of nanoceria and to define global descriptors of engineered nanoparticles (ENPs) bioactivity which may be useful in safer-by-design strategies of nanomaterialsThis research was supported by CTM2013-45775-C2-1-R and CTM2013-45775-C2-2-R grants from MINECO, the Dirección General de Universidades e Investigación de la Comunidad de Madrid, Research Network S2013/MAE-2716 and National Science Foundation for Nanotechnology Research (EECS – 0901503, CBET-1261956). Gerardo Pulido-Reyes thanks the Spanish Ministry of Education for the award of an FPU grant.Nature Publishing GroupDepartamento de BiologíaFacultad de Ciencias20152015-10-22research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/672888https://dx.doi.org/10.1038/srep15613reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6728882026-06-23T12:46:27Z
dc.title.none.fl_str_mv Untangling the biological effects of cerium oxide nanoparticles: The role of surface valence states
title Untangling the biological effects of cerium oxide nanoparticles: The role of surface valence states
spellingShingle Untangling the biological effects of cerium oxide nanoparticles: The role of surface valence states
Pulido Reyes, Gerardo
Cerium oxide nanoparticles
Cell systems
Aquatic microorganism
Toxicity
Biología y Biomedicina / Biología
title_short Untangling the biological effects of cerium oxide nanoparticles: The role of surface valence states
title_full Untangling the biological effects of cerium oxide nanoparticles: The role of surface valence states
title_fullStr Untangling the biological effects of cerium oxide nanoparticles: The role of surface valence states
title_full_unstemmed Untangling the biological effects of cerium oxide nanoparticles: The role of surface valence states
title_sort Untangling the biological effects of cerium oxide nanoparticles: The role of surface valence states
dc.creator.none.fl_str_mv Pulido Reyes, Gerardo
Rodea-Palomares, Ismael
Das, Soumen
Sakthivel, Tamil Selvan
Leganés Nieto, Francisco
Rosal, Roberto
Seal, Sudipta
Fernández Piñas, Francisca
author Pulido Reyes, Gerardo
author_facet Pulido Reyes, Gerardo
Rodea-Palomares, Ismael
Das, Soumen
Sakthivel, Tamil Selvan
Leganés Nieto, Francisco
Rosal, Roberto
Seal, Sudipta
Fernández Piñas, Francisca
author_role author
author2 Rodea-Palomares, Ismael
Das, Soumen
Sakthivel, Tamil Selvan
Leganés Nieto, Francisco
Rosal, Roberto
Seal, Sudipta
Fernández Piñas, Francisca
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología
Facultad de Ciencias
dc.subject.none.fl_str_mv Cerium oxide nanoparticles
Cell systems
Aquatic microorganism
Toxicity
Biología y Biomedicina / Biología
topic Cerium oxide nanoparticles
Cell systems
Aquatic microorganism
Toxicity
Biología y Biomedicina / Biología
description Cerium oxide nanoparticles (nanoceria; CNPs) have been found to have both pro-oxidant and antioxidant effects on different cell systems or organisms. In order to untangle the mechanisms which underlie the biological activity of nanoceria, we have studied the effect of five different CNPs on a model relevant aquatic microorganism. Neither shape, concentration, synthesis method, surface charge (ζ-potential), nor nominal size had any influence in the observed biological activity. The main driver of toxicity was found to be the percentage of surface content of Ce3+ sites: CNP1 (58%) and CNP5 (40%) were found to be toxic whereas CNP2 (28%), CNP3 (36%) and CNP4 (26%) were found to be non-toxic. The colloidal stability and redox chemistry of the most and least toxic CNPs, CNP1 and CNP2, respectively, were modified by incubation with iron and phosphate buffers. Blocking surface Ce3+ sites of the most toxic CNP, CNP1, with phosphate treatment reverted toxicity and stimulated growth. Colloidal destabilization with Fe treatment only increased toxicity of CNP1. The results of this study are relevant in the understanding of the main drivers of biological activity of nanoceria and to define global descriptors of engineered nanoparticles (ENPs) bioactivity which may be useful in safer-by-design strategies of nanomaterials
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-10-22
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/672888
https://dx.doi.org/10.1038/srep15613
url http://hdl.handle.net/10486/672888
https://dx.doi.org/10.1038/srep15613
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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