Modulation of Motor Cortex Excitability Predicts Antidepressant Response to Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation

Background: Repetitive transcranial magnetic stimulation (RTMS) targeting the left dorsolateral prefrontal cortex (DLPFC) is a treatment option for patients with medication-resistant major depressive disorder (MDD). However, antidepressant response is variable and there are currently no response pre...

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Detalles Bibliográficos
Autores: Oliveira-Maia, Albino J.|||0000-0001-5071-3007, Press, Daniel, Pascual Leone, Álvaro|||0000-0001-8975-0382
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:196496
Acceso en línea:https://ddd.uab.cat/record/196496
https://dx.doi.org/urn:doi:10.1016/j.brs.2017.03.013
Access Level:acceso abierto
Palabra clave:MDD
Rtms
Dorsolateral prefrontal cortex
Motor cortex
Excitability
Antidepressant response prediction
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spelling Modulation of Motor Cortex Excitability Predicts Antidepressant Response to Prefrontal Cortex Repetitive Transcranial Magnetic StimulationOliveira-Maia, Albino J.|||0000-0001-5071-3007Press, DanielPascual Leone, Álvaro|||0000-0001-8975-0382MDDRtmsDorsolateral prefrontal cortexMotor cortexExcitabilityAntidepressant response predictionBackground: Repetitive transcranial magnetic stimulation (RTMS) targeting the left dorsolateral prefrontal cortex (DLPFC) is a treatment option for patients with medication-resistant major depressive disorder (MDD). However, antidepressant response is variable and there are currently no response predictors with sufficient accuracy for clinical use. Objective: We report on results of an observational open-label study to determine whether the modulatory effect of 10 Hz motor cortex (MC) rTMS is predictive of the antidepressant effect of 10 Hz DLPFC rTMS. Methods: Fifty-one medication-resistant MDD patients were enrolled for a 10-day treatment course of DLPFC rTMS and antidepressant response was assessed according to post-treatment reduction of the 17-item Hamilton Rating Scale for Depression score. Prior to treatment, we assessed the modulation of motor evoked potential (MEP) amplitude by MC rTMS. MEP's were induced with single TMS pulses and measured using surface electromyography. MEP modulation was calculated as the change of mean MEP amplitude after MC rTMS. Results: MEP modulation proved to be a robust predictor of reduction of clinician-rated depression severity following the course of DLPFC rTMS: larger MC rTMS-induced increase of corticospinal excitability anticipated a better antidepressant response. This was found both in univariate analyses (Spearman regression: rho=0.43, p<0.005) and a multivariable linear regression model (β=0.25, p<0.0001) controlling for baseline depression severity, age and resting motor threshold. Conclusions: These findings suggest that MC rTMS-induced modulation of corticospinal excitability warrants further evaluation as a potential predictive biomarker of antidepressant response to left DLPFC 10 Hz rTMS. 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/196496https://dx.doi.org/urn:doi:10.1016/j.brs.2017.03.013reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1964962026-06-06T12:50:31Z
dc.title.none.fl_str_mv Modulation of Motor Cortex Excitability Predicts Antidepressant Response to Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation
title Modulation of Motor Cortex Excitability Predicts Antidepressant Response to Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation
spellingShingle Modulation of Motor Cortex Excitability Predicts Antidepressant Response to Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation
Oliveira-Maia, Albino J.|||0000-0001-5071-3007
MDD
Rtms
Dorsolateral prefrontal cortex
Motor cortex
Excitability
Antidepressant response prediction
title_short Modulation of Motor Cortex Excitability Predicts Antidepressant Response to Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation
title_full Modulation of Motor Cortex Excitability Predicts Antidepressant Response to Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation
title_fullStr Modulation of Motor Cortex Excitability Predicts Antidepressant Response to Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation
title_full_unstemmed Modulation of Motor Cortex Excitability Predicts Antidepressant Response to Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation
title_sort Modulation of Motor Cortex Excitability Predicts Antidepressant Response to Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation
dc.creator.none.fl_str_mv Oliveira-Maia, Albino J.|||0000-0001-5071-3007
Press, Daniel
Pascual Leone, Álvaro|||0000-0001-8975-0382
author Oliveira-Maia, Albino J.|||0000-0001-5071-3007
author_facet Oliveira-Maia, Albino J.|||0000-0001-5071-3007
Press, Daniel
Pascual Leone, Álvaro|||0000-0001-8975-0382
author_role author
author2 Press, Daniel
Pascual Leone, Álvaro|||0000-0001-8975-0382
author2_role author
author
dc.subject.none.fl_str_mv MDD
Rtms
Dorsolateral prefrontal cortex
Motor cortex
Excitability
Antidepressant response prediction
topic MDD
Rtms
Dorsolateral prefrontal cortex
Motor cortex
Excitability
Antidepressant response prediction
description Background: Repetitive transcranial magnetic stimulation (RTMS) targeting the left dorsolateral prefrontal cortex (DLPFC) is a treatment option for patients with medication-resistant major depressive disorder (MDD). However, antidepressant response is variable and there are currently no response predictors with sufficient accuracy for clinical use. Objective: We report on results of an observational open-label study to determine whether the modulatory effect of 10 Hz motor cortex (MC) rTMS is predictive of the antidepressant effect of 10 Hz DLPFC rTMS. Methods: Fifty-one medication-resistant MDD patients were enrolled for a 10-day treatment course of DLPFC rTMS and antidepressant response was assessed according to post-treatment reduction of the 17-item Hamilton Rating Scale for Depression score. Prior to treatment, we assessed the modulation of motor evoked potential (MEP) amplitude by MC rTMS. MEP's were induced with single TMS pulses and measured using surface electromyography. MEP modulation was calculated as the change of mean MEP amplitude after MC rTMS. Results: MEP modulation proved to be a robust predictor of reduction of clinician-rated depression severity following the course of DLPFC rTMS: larger MC rTMS-induced increase of corticospinal excitability anticipated a better antidepressant response. This was found both in univariate analyses (Spearman regression: rho=0.43, p<0.005) and a multivariable linear regression model (β=0.25, p<0.0001) controlling for baseline depression severity, age and resting motor threshold. Conclusions: These findings suggest that MC rTMS-induced modulation of corticospinal excitability warrants further evaluation as a potential predictive biomarker of antidepressant response to left DLPFC 10 Hz rTMS.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/196496
https://dx.doi.org/urn:doi:10.1016/j.brs.2017.03.013
url https://ddd.uab.cat/record/196496
https://dx.doi.org/urn:doi:10.1016/j.brs.2017.03.013
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
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https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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