Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019.

Analysis of sequencing data for 143 blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae isolates from 13 European national collections and the public domain resulted in the identification of 15 previously undetected multi-country transmission clusters. For 10 clusters, cases had prior travel/hosp...

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Authors: Ludden, Catherine, Lötsch, Felix, Alm, Erik, Kumar, Narender, Johansson, Karin, Albiger, Barbara, Huang, Te-Din, Denis, Olivier, Hammerum, Anette M, Hasman, Henrik, Jalava, Jari, Räisänen, Kati, Dortet, Laurent, Jousset, Agnès B, Gatermann, Sören, Haller, Sebastian, Cormican, Martin, Brennan, Wendy, Del Grosso, María, Monaco, Monica, Schouls, Leo, Samuelsen, Ørjan, Pirš, Mateja, Cerar, Tjaša, Sjöström, Karin, Edquist, Petra, Hopkins, Katie L, Struelens, Marc J, Palm, Daniel, Monnet, Dominique L, Kohlenberg, Anke, Oteo-Iglesias, Jesus, Perez-Vazquez, Maria
Format: article
Publication Date:2020
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/10866
Online Access:http://hdl.handle.net/20.500.12105/10866
Access Level:Open access
Keyword:Klebsiella pneumonia
OXA-48
NDM-1
Carbapenem-resistant Enterobacterales
Carbapenemase
Cross-border import
Surveillance
Whole genome sequencing
Description
Summary:Analysis of sequencing data for 143 blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae isolates from 13 European national collections and the public domain resulted in the identification of 15 previously undetected multi-country transmission clusters. For 10 clusters, cases had prior travel/hospitalisation history in countries outside of the European Union including Egypt, Iran, Morocco, Russia, Serbia, Tunisia and Turkey. These findings highlight the benefit of European whole genome sequencing-based surveillance and data sharing for control of antimicrobial resistance.

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