The regulation of Atonal 1 and the origin of hair cells in the inner ear
The vertebrate inner ear is the organ responsible for the senses of balance, acceleration and audition. Three cell types form the functional unit of the ear: hair cells, neurons and supporting cells. Atoh1 and Neurog1, two bHLH genes, drive differentiation of hair cells and neurons, respectively. Ha...
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| Formato: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Recursos: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/565808 |
| Acesso em linha: | http://hdl.handle.net/10803/565808 |
| Access Level: | acceso abierto |
| Palavra-chave: | Hair cells Inner ear bHLH factors Neural progenitors Sensory Células ciliadas Oído interno Factores bHLH Progenitores neuronales Sensorial 577 |
| Resumo: | The vertebrate inner ear is the organ responsible for the senses of balance, acceleration and audition. Three cell types form the functional unit of the ear: hair cells, neurons and supporting cells. Atoh1 and Neurog1, two bHLH genes, drive differentiation of hair cells and neurons, respectively. Hair cell and neuronal competence is established early in development. However, hair cell differentiation is delayed with respect to neurons. In this work, I provide evidence for a molecular mechanism that underlies the repression of Atoh1 by Neurog1. Neurog1 is able to reduce the levels of Atoh1 protein and as a consequence, Atoh1 cannot activate its own expression. This provides a novel mechanism for bHLH interactions by which neurons are forced to develop before hair cells during embryonic development. |
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