The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.

Mesoporous bioactive glasses (MBGs) in the system SiO2-CaO-P2O5-Ga2O3 have been synthesized by the evaporation induced self-assembly method and subsequent impregnation with Ga cations. Two different compositions have been prepared and the local environment of Ga(III) has been characterized using 29S...

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Detalhes bibliográficos
Autores: Gómez Cerezo, María Natividad, Verron, E, Montouillout, V, Fayon, F, Lagadec, P, Bouler, J.M., Bujoli, B, Arcos Navarrete, Daniel, Vallet Regí, María Dulce Nombre
Formato: artículo
Fecha de publicación:2018
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/12205
Acesso em linha:https://hdl.handle.net/20.500.14352/12205
Access Level:acceso abierto
Palavra-chave:546
615.46
Gallium
Mesoporous bioactive glasses
Osteoblast
Osteoclast
Osteoporosis
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
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oai_identifier_str oai:docta.ucm.es:20.500.14352/12205
network_acronym_str ES
network_name_str España
repository_id_str
spelling The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.Gómez Cerezo, María NatividadVerron, EMontouillout, VFayon, FLagadec, PBouler, J.M.Bujoli, BArcos Navarrete, DanielVallet Regí, María Dulce Nombre546615.46GalliumMesoporous bioactive glassesOsteoblastOsteoclastOsteoporosisMaterialesQuímica inorgánica (Farmacia)3312 Tecnología de MaterialesMesoporous bioactive glasses (MBGs) in the system SiO2-CaO-P2O5-Ga2O3 have been synthesized by the evaporation induced self-assembly method and subsequent impregnation with Ga cations. Two different compositions have been prepared and the local environment of Ga(III) has been characterized using 29Si, 71Ga and 31P NMR analysis, demonstrating that Ga(III) is efficiently incorporated as both, network former (GaO4 units) and network modifier (GaO6 units). In vitro bioactivity tests evidenced that Ga-containing MBGs retain their capability for nucleation and growth of an apatite-like layer in contact with a simulated body fluid with ion concentrations nearly equal to those of human blood plasma. Finally, in vitro cell culture tests evidenced that Ga incorporation results in a selective effect on osteoblasts and osteoclasts. Indeed, the presence of this element enhances the early differentiation towards osteoblast phenotype while disturbing osteoclastogenesis. Considering these results, Ga-doped MBGs might be proposed as bone substitutes, especially in osteoporosis scenarios.ElsevierUniversidad Complutense de Madrid20182018-06-3020182018-06-30journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/12205reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/122052026-06-02T12:44:21Z
dc.title.none.fl_str_mv The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.
title The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.
spellingShingle The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.
Gómez Cerezo, María Natividad
546
615.46
Gallium
Mesoporous bioactive glasses
Osteoblast
Osteoclast
Osteoporosis
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
title_short The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.
title_full The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.
title_fullStr The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.
title_full_unstemmed The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.
title_sort The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.
dc.creator.none.fl_str_mv Gómez Cerezo, María Natividad
Verron, E
Montouillout, V
Fayon, F
Lagadec, P
Bouler, J.M.
Bujoli, B
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
author Gómez Cerezo, María Natividad
author_facet Gómez Cerezo, María Natividad
Verron, E
Montouillout, V
Fayon, F
Lagadec, P
Bouler, J.M.
Bujoli, B
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
author_role author
author2 Verron, E
Montouillout, V
Fayon, F
Lagadec, P
Bouler, J.M.
Bujoli, B
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 546
615.46
Gallium
Mesoporous bioactive glasses
Osteoblast
Osteoclast
Osteoporosis
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
topic 546
615.46
Gallium
Mesoporous bioactive glasses
Osteoblast
Osteoclast
Osteoporosis
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
description Mesoporous bioactive glasses (MBGs) in the system SiO2-CaO-P2O5-Ga2O3 have been synthesized by the evaporation induced self-assembly method and subsequent impregnation with Ga cations. Two different compositions have been prepared and the local environment of Ga(III) has been characterized using 29Si, 71Ga and 31P NMR analysis, demonstrating that Ga(III) is efficiently incorporated as both, network former (GaO4 units) and network modifier (GaO6 units). In vitro bioactivity tests evidenced that Ga-containing MBGs retain their capability for nucleation and growth of an apatite-like layer in contact with a simulated body fluid with ion concentrations nearly equal to those of human blood plasma. Finally, in vitro cell culture tests evidenced that Ga incorporation results in a selective effect on osteoblasts and osteoclasts. Indeed, the presence of this element enhances the early differentiation towards osteoblast phenotype while disturbing osteoclastogenesis. Considering these results, Ga-doped MBGs might be proposed as bone substitutes, especially in osteoporosis scenarios.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-06-30
2018
2018-06-30
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/12205
url https://hdl.handle.net/20.500.14352/12205
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.228081

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