Continuous glucose monitoring as an alternative for cystic fibrosis related diabetes screening and diagnosis

Background and aims: The data regarding the capacity of HbA1c and Continuous Glucose Monitoring (CGM) to diagnose Cystic Fibrosis Related Diabetes (CFRD) are uncertain. We studied HbA1c, classical CGM indexes, and novel glucodensities CGM metrics’ ability to distinguish CFRD based on Oral Glucose To...

ver descrição completa

Detalhes bibliográficos
Autores: Aguilera García, Irene, Vázquez Pérez, Patricia, Lopez Plaza, Bricia, Matabuena, M., García Moreno, R. M., Palma Milla, Samara, Zamarrón de Lucas, Ester, Prados Sánchez, María Concepción, González Pérez de Villar, Noemí
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/742220
Acesso em linha:https://hdl.handle.net/10486/742220
https://dx.doi.org/10.1016/j.diabres.2025.112952
Access Level:acceso abierto
Palavra-chave:Cystic Fibrosis-Related Diabetes
Continuous Glucose Monitoring
HbA1c
Glucodensities
Medicina
id ES_cbf9b7794629debaa9113e29aa5f1541
oai_identifier_str oai:repositorio.uam.es:10486/742220
network_acronym_str ES
network_name_str España
repository_id_str
spelling Continuous glucose monitoring as an alternative for cystic fibrosis related diabetes screening and diagnosisAguilera García, IreneVázquez Pérez, PatriciaLopez Plaza, BriciaMatabuena, M.García Moreno, R. M.Palma Milla, SamaraZamarrón de Lucas, EsterPrados Sánchez, María ConcepciónGonzález Pérez de Villar, NoemíCystic Fibrosis-Related DiabetesContinuous Glucose MonitoringHbA1cGlucodensitiesMedicinaBackground and aims: The data regarding the capacity of HbA1c and Continuous Glucose Monitoring (CGM) to diagnose Cystic Fibrosis Related Diabetes (CFRD) are uncertain. We studied HbA1c, classical CGM indexes, and novel glucodensities CGM metrics’ ability to distinguish CFRD based on Oral Glucose Tolerance Test (OGTT) results. Methods: We carried out a prospective observational study involving 38 patients who had had an OGTT test within the previous 6 months and who accepted wearing a CGM sensor for 14 days. Patients answered a questionnaire regarding preferences for CFRD screening. Results: Participants reported a preference for a simpler method for CFRD screening, such as HbA1c, but CGM was better accepted than OGTT. Regarding CGM metrics, time above 180 mg/dL over 6 % presented a sensitivity of 93 % (p = 0.042) and time above 140 mg/dL over 20 %, a specificity of 90 % (p = 0.032) for CFRD diagnosis. CGM metrics distinguished CFRD better than HbA1c, but glucodensities improved CGM diagnostic capacity with sensitivity and specificity over 85 %. Conclusion: In this exploratory study, glucodensities show better discriminatory capacity than HbA1c and CGM classic metrics in distinguishing early mild CFRD. This study supports the need for future larger prospective studies to define the most accepted screening method for CFRD, as well as the optimal cut-off point of CGM metrics and/or glucodensities for the diagnosis of CFRDElsevierDepartamento de MedicinaFacultad de Medicina20252025-10-19research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10486/742220https://dx.doi.org/10.1016/j.diabres.2025.112952reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7422202026-06-23T12:46:27Z
dc.title.none.fl_str_mv Continuous glucose monitoring as an alternative for cystic fibrosis related diabetes screening and diagnosis
title Continuous glucose monitoring as an alternative for cystic fibrosis related diabetes screening and diagnosis
spellingShingle Continuous glucose monitoring as an alternative for cystic fibrosis related diabetes screening and diagnosis
Aguilera García, Irene
Cystic Fibrosis-Related Diabetes
Continuous Glucose Monitoring
HbA1c
Glucodensities
Medicina
title_short Continuous glucose monitoring as an alternative for cystic fibrosis related diabetes screening and diagnosis
title_full Continuous glucose monitoring as an alternative for cystic fibrosis related diabetes screening and diagnosis
title_fullStr Continuous glucose monitoring as an alternative for cystic fibrosis related diabetes screening and diagnosis
title_full_unstemmed Continuous glucose monitoring as an alternative for cystic fibrosis related diabetes screening and diagnosis
title_sort Continuous glucose monitoring as an alternative for cystic fibrosis related diabetes screening and diagnosis
dc.creator.none.fl_str_mv Aguilera García, Irene
Vázquez Pérez, Patricia
Lopez Plaza, Bricia
Matabuena, M.
García Moreno, R. M.
Palma Milla, Samara
Zamarrón de Lucas, Ester
Prados Sánchez, María Concepción
González Pérez de Villar, Noemí
author Aguilera García, Irene
author_facet Aguilera García, Irene
Vázquez Pérez, Patricia
Lopez Plaza, Bricia
Matabuena, M.
García Moreno, R. M.
Palma Milla, Samara
Zamarrón de Lucas, Ester
Prados Sánchez, María Concepción
González Pérez de Villar, Noemí
author_role author
author2 Vázquez Pérez, Patricia
Lopez Plaza, Bricia
Matabuena, M.
García Moreno, R. M.
Palma Milla, Samara
Zamarrón de Lucas, Ester
Prados Sánchez, María Concepción
González Pérez de Villar, Noemí
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv Cystic Fibrosis-Related Diabetes
Continuous Glucose Monitoring
HbA1c
Glucodensities
Medicina
topic Cystic Fibrosis-Related Diabetes
Continuous Glucose Monitoring
HbA1c
Glucodensities
Medicina
description Background and aims: The data regarding the capacity of HbA1c and Continuous Glucose Monitoring (CGM) to diagnose Cystic Fibrosis Related Diabetes (CFRD) are uncertain. We studied HbA1c, classical CGM indexes, and novel glucodensities CGM metrics’ ability to distinguish CFRD based on Oral Glucose Tolerance Test (OGTT) results. Methods: We carried out a prospective observational study involving 38 patients who had had an OGTT test within the previous 6 months and who accepted wearing a CGM sensor for 14 days. Patients answered a questionnaire regarding preferences for CFRD screening. Results: Participants reported a preference for a simpler method for CFRD screening, such as HbA1c, but CGM was better accepted than OGTT. Regarding CGM metrics, time above 180 mg/dL over 6 % presented a sensitivity of 93 % (p = 0.042) and time above 140 mg/dL over 20 %, a specificity of 90 % (p = 0.032) for CFRD diagnosis. CGM metrics distinguished CFRD better than HbA1c, but glucodensities improved CGM diagnostic capacity with sensitivity and specificity over 85 %. Conclusion: In this exploratory study, glucodensities show better discriminatory capacity than HbA1c and CGM classic metrics in distinguishing early mild CFRD. This study supports the need for future larger prospective studies to define the most accepted screening method for CFRD, as well as the optimal cut-off point of CGM metrics and/or glucodensities for the diagnosis of CFRD
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-10-19
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10486/742220
https://dx.doi.org/10.1016/j.diabres.2025.112952
url https://hdl.handle.net/10486/742220
https://dx.doi.org/10.1016/j.diabres.2025.112952
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419635246366720
score 15.198674

Registos relacionados