Dendritic Boronic Acids for the Delivery of Diol-containing Drugs
This thesis outlines the preparation of polymeric micelles between boronic acid-functionalized PEG-dendritic block copolymers and diol-containing drugs, as a promising strategy in drug delivery. Taking advantage of terminal azide groups for functionalization, PEG-GATG dendritic block copolymers with...
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| Tipo de documento: | tese |
| Data de publicação: | 2020 |
| País: | España |
| Recursos: | Universidad de Santiago de Compostela (USC) |
| Repositório: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglês |
| OAI Identifier: | oai:minerva.usc.gal:10347/24412 |
| Acesso em linha: | http://hdl.handle.net/10347/24412 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Materias::Investigación::23 Química::2304 Química macromolecular::230409 Modificación de macromoléculas Materias::Investigación::23 Química::2304 Química macromolecular::230423 Síntesis de macromoléculas Materias::Investigación::23 Química::2390 Química farmacéutica::239001 Diseño. Síntesis y estudio nuevos fármacos |
| Resumo: | This thesis outlines the preparation of polymeric micelles between boronic acid-functionalized PEG-dendritic block copolymers and diol-containing drugs, as a promising strategy in drug delivery. Taking advantage of terminal azide groups for functionalization, PEG-GATG dendritic block copolymers with peripheral boronic acids were obtained via reductive amination with 2-formylphenylboronic. The ability of the resulting boronic acid-functionalized copolymers (PEG-[G3]-BO2H2) to encapsulate drugs incorporating 1,2- and 1,3-diols into micelles, via selective boronic ester formation, was assessed in aqueous media at pH 7.4. Gemcitabine, an anticancer drug was selected for a deeper study. After incorporation into micelles in the presence of catechol, the encapsulation efficiency and stability of the micelles were determined, and their toxicity profile studied. |
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