Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial Growth

Bacterial infections represent a major threat that can cause millions of deaths worldwide, where bacterial species can colonize and grow into highly resistant biofilms. Autonomous micromotor propulsion can improve the overall efficiency of bacterial growth inhibition versus other static processes, l...

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Autores: Cuntín Abal, Carmen|||0000-0001-5713-0971, Chávez Peraza, Miriam|||0000-0002-5512-7485, Jurado Sánchez, Beatriz|||0000-0002-6584-1949, Escarpa Miguel, Jesús Alberto|||0000-0002-7302-0948
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/65993
Acesso em linha:http://hdl.handle.net/10017/65993
https://dx.doi.org/10.1021/acs.chemmater.5c00885
Access Level:acceso abierto
Palavra-chave:Química
Chemistry
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spelling Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial GrowthCuntín Abal, Carmen|||0000-0001-5713-0971Chávez Peraza, Miriam|||0000-0002-5512-7485Jurado Sánchez, Beatriz|||0000-0002-6584-1949Escarpa Miguel, Jesús Alberto|||0000-0002-7302-0948QuímicaChemistryBacterial infections represent a major threat that can cause millions of deaths worldwide, where bacterial species can colonize and grow into highly resistant biofilms. Autonomous micromotor propulsion can improve the overall efficiency of bacterial growth inhibition versus other static processes, leading to novel methods for bacterial treatment. Here, biotemplated magnetic and photocatalytic micromotors are synthesized using E. coli and S. aureus as bacterial templates with different morphological features, such as shape and size, to obtain reproducible micromotors, followed by decoration with Fe3O4 nanoparticles for magnetic guidance into biofilms. Then, photoactive BiOCl crystals are grown on the micromotor surface for in situ photocatalytic generation of reactive oxygen species (ROS) for efficient bacterial growth inhibition. Thanks to their high photostability, E. coli@Fe3O4@BiOCl micromotors enabled controlled and efficient ROS production under sterilization conditions by using 375 nm light to trigger an oxygen vacancy generation mechanism within a biocompatible, tailored 3D-printed electrochemical cell. The (photo)electrochemical ROS generation correlated well with highly efficient bacterial growth inhibition, demonstrating the potential application of the collective dynamics of these multifunctional biotemplate-based micromotors. The concepts described here are promising for the development of future strategies against resistant bacteria by understanding the underlying processes behind them.Ministerio de Ciencia, Innovación y UniversidadesComunidad de MadridJunta de Comunidades de Castilla la ManchaUniversidad de AlcaláEuropean UnionACS20252025-08-19journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/65993https://dx.doi.org/10.1021/acs.chemmater.5c00885reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengMCIN Not available PID2020-118154GB-I00MCIN Not available PID2023-152298NB-I00MCIN Not available TED2021- 132720B−I00MCIN AEI Not available 501100011033CM Not available JIN%2F2021-012Junta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available SBPLY%2F23%2F180225%2F000058UAH Not available EPU-INV-UAH%2F2022%2F003open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/659932026-06-18T11:13:07Z
dc.title.none.fl_str_mv Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial Growth
title Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial Growth
spellingShingle Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial Growth
Cuntín Abal, Carmen|||0000-0001-5713-0971
Química
Chemistry
title_short Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial Growth
title_full Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial Growth
title_fullStr Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial Growth
title_full_unstemmed Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial Growth
title_sort Biotemplated Photocatalytic Micromotors for Effective Inhibition of Bacterial Growth
dc.creator.none.fl_str_mv Cuntín Abal, Carmen|||0000-0001-5713-0971
Chávez Peraza, Miriam|||0000-0002-5512-7485
Jurado Sánchez, Beatriz|||0000-0002-6584-1949
Escarpa Miguel, Jesús Alberto|||0000-0002-7302-0948
author Cuntín Abal, Carmen|||0000-0001-5713-0971
author_facet Cuntín Abal, Carmen|||0000-0001-5713-0971
Chávez Peraza, Miriam|||0000-0002-5512-7485
Jurado Sánchez, Beatriz|||0000-0002-6584-1949
Escarpa Miguel, Jesús Alberto|||0000-0002-7302-0948
author_role author
author2 Chávez Peraza, Miriam|||0000-0002-5512-7485
Jurado Sánchez, Beatriz|||0000-0002-6584-1949
Escarpa Miguel, Jesús Alberto|||0000-0002-7302-0948
author2_role author
author
author
dc.subject.none.fl_str_mv Química
Chemistry
topic Química
Chemistry
description Bacterial infections represent a major threat that can cause millions of deaths worldwide, where bacterial species can colonize and grow into highly resistant biofilms. Autonomous micromotor propulsion can improve the overall efficiency of bacterial growth inhibition versus other static processes, leading to novel methods for bacterial treatment. Here, biotemplated magnetic and photocatalytic micromotors are synthesized using E. coli and S. aureus as bacterial templates with different morphological features, such as shape and size, to obtain reproducible micromotors, followed by decoration with Fe3O4 nanoparticles for magnetic guidance into biofilms. Then, photoactive BiOCl crystals are grown on the micromotor surface for in situ photocatalytic generation of reactive oxygen species (ROS) for efficient bacterial growth inhibition. Thanks to their high photostability, E. coli@Fe3O4@BiOCl micromotors enabled controlled and efficient ROS production under sterilization conditions by using 375 nm light to trigger an oxygen vacancy generation mechanism within a biocompatible, tailored 3D-printed electrochemical cell. The (photo)electrochemical ROS generation correlated well with highly efficient bacterial growth inhibition, demonstrating the potential application of the collective dynamics of these multifunctional biotemplate-based micromotors. The concepts described here are promising for the development of future strategies against resistant bacteria by understanding the underlying processes behind them.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-08-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/65993
https://dx.doi.org/10.1021/acs.chemmater.5c00885
url http://hdl.handle.net/10017/65993
https://dx.doi.org/10.1021/acs.chemmater.5c00885
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv MCIN Not available PID2020-118154GB-I00
MCIN Not available PID2023-152298NB-I00
MCIN Not available TED2021- 132720B−I00
MCIN AEI Not available 501100011033
CM Not available JIN%2F2021-012
Junta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available SBPLY%2F23%2F180225%2F000058
UAH Not available EPU-INV-UAH%2F2022%2F003
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ACS
publisher.none.fl_str_mv ACS
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
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