Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12-2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.

Invasive meningococcal disease (IMD) is associated with significant global morbidity and mortality and is addressed by conjugated polysaccharide and subcapsular vaccines. In Spain, data on 4CMenB vaccine strain coverage and antimicrobial susceptibility are limited. This study aimed to describe the g...

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Authors: Roca-Grande J, Mir-Cros A, Muñoz-Almagro C, Lung M, Bellés-Bellés A, Càmara J, Cercenado E, Galán-Ladero MÁ, Martín-Nalda A, Moreno-Mingorance A, Navarro de la Cruz D, Orellana MÁ, Palop B, Pérez-Argüello A, Puigsech-Boixeda G, Quesada MD, Rivera A, Rodriguez-Fernandez A, Ruiz de Gopegui E, Sarvisé C, Soler-Garcia A, Viñado B, Larrosa N, González-López JJ
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Fundació Sant Joan de Déu
Repository:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p28378
Online Access:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28378
Access Level:Open access
Keyword:4CMenB vaccine strain coverage
Neisseria meningitidis
antimicrobial susceptibility
cc213
gMATS
genomic epidemiology
whole genome sequencing
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spelling Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12-2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.Roca-Grande JMir-Cros AMuñoz-Almagro CLung MBellés-Bellés ACàmara JCercenado EGalán-Ladero MÁMartín-Nalda AMoreno-Mingorance ANavarro de la Cruz DOrellana MÁPalop BPérez-Argüello APuigsech-Boixeda GQuesada MDRivera ARodriguez-Fernandez ARuiz de Gopegui ESarvisé CSoler-Garcia AViñado BLarrosa NGonzález-López JJ4CMenB vaccine strain coverageNeisseria meningitidisantimicrobial susceptibilitycc213gMATSgenomic epidemiologywhole genome sequencingInvasive meningococcal disease (IMD) is associated with significant global morbidity and mortality and is addressed by conjugated polysaccharide and subcapsular vaccines. In Spain, data on 4CMenB vaccine strain coverage and antimicrobial susceptibility are limited. This study aimed to describe the genomic epidemiology, predict 4CMenB vaccine strain coverage, and assess antimicrobial susceptibility of 323 Neisseria meningitidis isolates causing IMD, collected from 57 Clinical Microbiology Laboratories in Spain over 12 years (2011/12-2022/23). Whole genome sequencing was performed to identify serogroup, clonal complex (cc), and antimicrobial resistance determinants. Vaccine strain coverage for serogroup B (MenB) isolates was predicted using the genetic Meningococcal Antigen Typing System approach. The most prevalent serogroups were B (57.9%), W (21.4%), C (10.4%), and Y (8.4%). MenB predominated throughout most seasons, except during the 2019/20 season when serogroup W peaked. Post-COVID-19 pandemic, MenB remained the most frequent (70.2%). Thirteen cc were identified among MenB isolates, with cc213 being the most prevalent (40.1%). Only 28.9% of MenB isolates were predicted to be covered by 4CMenB, with cc213 showing an exceptionally low coverage rate (5.3%) due to antigenic variants poorly targeted by the vaccine. Notably, cc213 was responsible for twice the proportion of MenB cases in 4CMenB-vaccinated versus unvaccinated. All isolates were susceptible to third generation cephalosporins, and 13.5% showed penicillin resistance. This study highlights the alarming prevalence of cc213 among MenB IMD cases in Spain and the limited 4CMenB coverage against this cc. The disproportionate representation of cc213 in vaccinated individuals underscores its potential to compromise vaccine effectiveness.TAYLOR & FRANCIS LTD2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28378Emerging Microbes & InfectionsISSN: 22221751reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p283782026-05-27T12:37:41Z
dc.title.none.fl_str_mv Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12-2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.
title Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12-2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.
spellingShingle Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12-2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.
Roca-Grande J
4CMenB vaccine strain coverage
Neisseria meningitidis
antimicrobial susceptibility
cc213
gMATS
genomic epidemiology
whole genome sequencing
title_short Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12-2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.
title_full Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12-2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.
title_fullStr Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12-2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.
title_full_unstemmed Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12-2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.
title_sort Genomic characterization of invasive Neisseria meningitidis in Spain (2011/12-2022/23): expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.
dc.creator.none.fl_str_mv Roca-Grande J
Mir-Cros A
Muñoz-Almagro C
Lung M
Bellés-Bellés A
Càmara J
Cercenado E
Galán-Ladero MÁ
Martín-Nalda A
Moreno-Mingorance A
Navarro de la Cruz D
Orellana MÁ
Palop B
Pérez-Argüello A
Puigsech-Boixeda G
Quesada MD
Rivera A
Rodriguez-Fernandez A
Ruiz de Gopegui E
Sarvisé C
Soler-Garcia A
Viñado B
Larrosa N
González-López JJ
author Roca-Grande J
author_facet Roca-Grande J
Mir-Cros A
Muñoz-Almagro C
Lung M
Bellés-Bellés A
Càmara J
Cercenado E
Galán-Ladero MÁ
Martín-Nalda A
Moreno-Mingorance A
Navarro de la Cruz D
Orellana MÁ
Palop B
Pérez-Argüello A
Puigsech-Boixeda G
Quesada MD
Rivera A
Rodriguez-Fernandez A
Ruiz de Gopegui E
Sarvisé C
Soler-Garcia A
Viñado B
Larrosa N
González-López JJ
author_role author
author2 Mir-Cros A
Muñoz-Almagro C
Lung M
Bellés-Bellés A
Càmara J
Cercenado E
Galán-Ladero MÁ
Martín-Nalda A
Moreno-Mingorance A
Navarro de la Cruz D
Orellana MÁ
Palop B
Pérez-Argüello A
Puigsech-Boixeda G
Quesada MD
Rivera A
Rodriguez-Fernandez A
Ruiz de Gopegui E
Sarvisé C
Soler-Garcia A
Viñado B
Larrosa N
González-López JJ
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 4CMenB vaccine strain coverage
Neisseria meningitidis
antimicrobial susceptibility
cc213
gMATS
genomic epidemiology
whole genome sequencing
topic 4CMenB vaccine strain coverage
Neisseria meningitidis
antimicrobial susceptibility
cc213
gMATS
genomic epidemiology
whole genome sequencing
description Invasive meningococcal disease (IMD) is associated with significant global morbidity and mortality and is addressed by conjugated polysaccharide and subcapsular vaccines. In Spain, data on 4CMenB vaccine strain coverage and antimicrobial susceptibility are limited. This study aimed to describe the genomic epidemiology, predict 4CMenB vaccine strain coverage, and assess antimicrobial susceptibility of 323 Neisseria meningitidis isolates causing IMD, collected from 57 Clinical Microbiology Laboratories in Spain over 12 years (2011/12-2022/23). Whole genome sequencing was performed to identify serogroup, clonal complex (cc), and antimicrobial resistance determinants. Vaccine strain coverage for serogroup B (MenB) isolates was predicted using the genetic Meningococcal Antigen Typing System approach. The most prevalent serogroups were B (57.9%), W (21.4%), C (10.4%), and Y (8.4%). MenB predominated throughout most seasons, except during the 2019/20 season when serogroup W peaked. Post-COVID-19 pandemic, MenB remained the most frequent (70.2%). Thirteen cc were identified among MenB isolates, with cc213 being the most prevalent (40.1%). Only 28.9% of MenB isolates were predicted to be covered by 4CMenB, with cc213 showing an exceptionally low coverage rate (5.3%) due to antigenic variants poorly targeted by the vaccine. Notably, cc213 was responsible for twice the proportion of MenB cases in 4CMenB-vaccinated versus unvaccinated. All isolates were susceptible to third generation cephalosporins, and 13.5% showed penicillin resistance. This study highlights the alarming prevalence of cc213 among MenB IMD cases in Spain and the limited 4CMenB coverage against this cc. The disproportionate representation of cc213 in vaccinated individuals underscores its potential to compromise vaccine effectiveness.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28378
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=28378
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv TAYLOR & FRANCIS LTD
publisher.none.fl_str_mv TAYLOR & FRANCIS LTD
dc.source.none.fl_str_mv Emerging Microbes & Infections
ISSN: 22221751
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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