The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics

The presence of plastic waste in our environment has continued growing and become an important environmental concern. Because of its degradation into micro- and nanoplastics (MNPLs), MNPLs are becoming environmental pollutants of special environmental/health concern. Since ingestion is one of the ma...

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Autores: Vela, Lourdes|||0000-0002-5785-8441, Villacorta, Aliro|||0000-0003-2737-4232, Venus, Tom, Estrela-Lopis, Irina, Pastor Benito, Susana|||0000-0003-2454-5163, García Rodríguez, Alba|||0000-0002-1175-7418, Rubio Lorente, Laura|||0000-0002-2088-3803, Marcos Dauder, Ricardo|||0000-0001-7891-357X, Hernández Bonilla, Alba|||0000-0001-6938-1233
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:275146
Acesso em linha:https://ddd.uab.cat/record/275146
https://dx.doi.org/urn:doi:10.1016/j.envpol.2023.121656
Access Level:acceso abierto
Palavra-chave:Nanoplastics
Polystyrene
Digestion
Characterization
Cell uptake
Hazard effects
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spelling The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplasticsVela, Lourdes|||0000-0002-5785-8441Villacorta, Aliro|||0000-0003-2737-4232Venus, TomEstrela-Lopis, IrinaPastor Benito, Susana|||0000-0003-2454-5163García Rodríguez, Alba|||0000-0002-1175-7418Rubio Lorente, Laura|||0000-0002-2088-3803Marcos Dauder, Ricardo|||0000-0001-7891-357XHernández Bonilla, Alba|||0000-0001-6938-1233NanoplasticsPolystyreneDigestionCharacterizationCell uptakeHazard effectsThe presence of plastic waste in our environment has continued growing and become an important environmental concern. Because of its degradation into micro- and nanoplastics (MNPLs), MNPLs are becoming environmental pollutants of special environmental/health concern. Since ingestion is one of the main exposure routes to MNPLs, the potential effects of digestion on the physicochemical/biological characteristics of polystyrene nanoplastics (PSNPLs) were determined. The results indicated a high tendency of digested PSNPLs to agglomerate and a differential presence of proteins on their surface. Interestingly, digested PSNPLs showed greater cell uptake than undigested PSNPLs in all three tested cell lines (TK6, Raji-B, and THP-1). Despite these differences in cell uptake, no differences in toxicity were observed except for high and assumed unrealistic exposures. When oxidative stress and genotoxicity induction were determined, the low effects observed after exposure to undigested PDNPLs were not observed in the digested ones. This indicated that the greater ability of digested PSNPLs to internalize was not accompanied by a greater hazard. This type of analysis should be performed with other MNPLs of varying sizes and chemical compositions. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/275146https://dx.doi.org/urn:doi:10.1016/j.envpol.2023.121656reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 801370European Commission https://doi.org/10.13039/501100000780 965196Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116789RB-C43Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00731open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2751462026-06-06T12:50:31Z
dc.title.none.fl_str_mv The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
title The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
spellingShingle The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
Vela, Lourdes|||0000-0002-5785-8441
Nanoplastics
Polystyrene
Digestion
Characterization
Cell uptake
Hazard effects
title_short The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
title_full The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
title_fullStr The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
title_full_unstemmed The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
title_sort The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
dc.creator.none.fl_str_mv Vela, Lourdes|||0000-0002-5785-8441
Villacorta, Aliro|||0000-0003-2737-4232
Venus, Tom
Estrela-Lopis, Irina
Pastor Benito, Susana|||0000-0003-2454-5163
García Rodríguez, Alba|||0000-0002-1175-7418
Rubio Lorente, Laura|||0000-0002-2088-3803
Marcos Dauder, Ricardo|||0000-0001-7891-357X
Hernández Bonilla, Alba|||0000-0001-6938-1233
author Vela, Lourdes|||0000-0002-5785-8441
author_facet Vela, Lourdes|||0000-0002-5785-8441
Villacorta, Aliro|||0000-0003-2737-4232
Venus, Tom
Estrela-Lopis, Irina
Pastor Benito, Susana|||0000-0003-2454-5163
García Rodríguez, Alba|||0000-0002-1175-7418
Rubio Lorente, Laura|||0000-0002-2088-3803
Marcos Dauder, Ricardo|||0000-0001-7891-357X
Hernández Bonilla, Alba|||0000-0001-6938-1233
author_role author
author2 Villacorta, Aliro|||0000-0003-2737-4232
Venus, Tom
Estrela-Lopis, Irina
Pastor Benito, Susana|||0000-0003-2454-5163
García Rodríguez, Alba|||0000-0002-1175-7418
Rubio Lorente, Laura|||0000-0002-2088-3803
Marcos Dauder, Ricardo|||0000-0001-7891-357X
Hernández Bonilla, Alba|||0000-0001-6938-1233
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Nanoplastics
Polystyrene
Digestion
Characterization
Cell uptake
Hazard effects
topic Nanoplastics
Polystyrene
Digestion
Characterization
Cell uptake
Hazard effects
description The presence of plastic waste in our environment has continued growing and become an important environmental concern. Because of its degradation into micro- and nanoplastics (MNPLs), MNPLs are becoming environmental pollutants of special environmental/health concern. Since ingestion is one of the main exposure routes to MNPLs, the potential effects of digestion on the physicochemical/biological characteristics of polystyrene nanoplastics (PSNPLs) were determined. The results indicated a high tendency of digested PSNPLs to agglomerate and a differential presence of proteins on their surface. Interestingly, digested PSNPLs showed greater cell uptake than undigested PSNPLs in all three tested cell lines (TK6, Raji-B, and THP-1). Despite these differences in cell uptake, no differences in toxicity were observed except for high and assumed unrealistic exposures. When oxidative stress and genotoxicity induction were determined, the low effects observed after exposure to undigested PDNPLs were not observed in the digested ones. This indicated that the greater ability of digested PSNPLs to internalize was not accompanied by a greater hazard. This type of analysis should be performed with other MNPLs of varying sizes and chemical compositions.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/275146
https://dx.doi.org/urn:doi:10.1016/j.envpol.2023.121656
url https://ddd.uab.cat/record/275146
https://dx.doi.org/urn:doi:10.1016/j.envpol.2023.121656
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 801370
European Commission https://doi.org/10.13039/501100000780 965196
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116789RB-C43
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00731
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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