The 2018 biomembrane curvature and remodeling roadmap

The importance of curvature as a structural feature of biological membranes has been recognized for many years and has fascinated scientists from a wide range of different backgrounds. On the one hand, changes in membrane morphology are involved in a plethora of phenomena involving the plasma membra...

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Detalles Bibliográficos
Autores: Bassereau, Patricia, Jin, Rui, Baumgart, Tobias, Deserno, Markus, Dimova, Rumiana, Frolov, Vadim, Bashkirov, Pavel V., Grubmüller, Helmut, Jahn, Reinhard, Risselada, H. Jelger, Johannes, Ludger, Kozlov, Michael M., Lipowsky, Reinhard, Pucadyil, Thomas J., Zeno, Wade F., Stachowiak, Jeanne C., Stamou, Dimitrios, Breuer, Artù, Lauritsen, Line, Simon, Camille, Sykes, Cécile, Voth, Gregory A., Weikl, Thomas R.
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/29751
Acceso en línea:http://hdl.handle.net/10810/29751
Access Level:acceso abierto
Palabra clave:biomembrane
curavture
remodeling
clathrin-mediated endocytosis
domain-containing proteins
membrane curvature
lipid-membranes
amphipathic helix
fluid membranes
bar domains
independent carriers
generating proteins
elastic properties
Descripción
Sumario:The importance of curvature as a structural feature of biological membranes has been recognized for many years and has fascinated scientists from a wide range of different backgrounds. On the one hand, changes in membrane morphology are involved in a plethora of phenomena involving the plasma membrane of eukaryotic cells, including endo-and exocytosis, phagocytosis and filopodia formation. On the other hand, a multitude of intracellular processes at the level of organelles rely on generation, modulation, and maintenance of membrane curvature to maintain the organelle shape and functionality. The contribution of biophysicists and biologists is essential for shedding light on the mechanistic understanding and quantification of these processes. Given the vast complexity of phenomena and mechanisms involved in the coupling between membrane shape and function, it is not always clear in what direction to advance to eventually arrive at an exhaustive understanding of this important research area. The 2018 Biomembrane Curvature and Remodeling Roadmap of Journal of Physics D: Applied Physics addresses this need for clarity and is intended to provide guidance both for students who have just entered the field as well as established scientists who would like to improve their orientation within this fascinating area.

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