Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life

An observational comparative study was designed to assess the fatty acids profile in erythrocyte membrane phospholipids of 30 preterm neonates (<32 weeks gestation) at birth and after 1 month of life versus a convenience sample of 10 infants born at term. The panel of fatty acids included the fam...

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Autores: Castillo Salinas, Félix|||0000-0003-3155-6290, Montaner Ramón, Alicia|||0000-0002-7327-0066, Castillo-Ferrer, Félix-Joel, Domingo-Carnice, Adrià, Cordobilla, Begoña|||0000-0002-0418-9387, Domingo, Joan Carles|||0000-0002-6356-0836
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:281757
Acesso em linha:https://ddd.uab.cat/record/281757
https://dx.doi.org/urn:doi:10.3390/nu14234956
Access Level:acceso abierto
Palavra-chave:Docosahexaenoic acid
Arachidonic acid
Linoleic acid
Eicosapentaenoic acid
Lipid profile
Preterm infants
Erythrocyte membrane
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spelling Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of LifeA Comparative Study with Infants at TermCastillo Salinas, Félix|||0000-0003-3155-6290Montaner Ramón, Alicia|||0000-0002-7327-0066Castillo-Ferrer, Félix-JoelDomingo-Carnice, AdriàCordobilla, Begoña|||0000-0002-0418-9387Domingo, Joan Carles|||0000-0002-6356-0836Docosahexaenoic acidArachidonic acidLinoleic acidEicosapentaenoic acidLipid profilePreterm infantsErythrocyte membraneAn observational comparative study was designed to assess the fatty acids profile in erythrocyte membrane phospholipids of 30 preterm neonates (<32 weeks gestation) at birth and after 1 month of life versus a convenience sample of 10 infants born at term. The panel of fatty acids included the families and components of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and n-6 and n-3 polyunsaturated fatty acids (PUFAs) as well as enzyme activity indexes and fatty acids ratios. At birth, the comparison of fatty acid families between preterm and term neonates showed a significantly higher content of SFAs and n-6 PUFAs, and a significantly lower content of MUFAs and n-3 PUFAs in the preterm group. After 30 days of life, significantly higher levels of n-6 PUFAs and significantly lower levels of n-3 PUFAs among preterm neonates persisted. At 30 days of birth, n-6 PUFA/n-3 PUFA and arachidonic acid (ARA) ARA/DHA remained significantly elevated, and DHA sufficiency index significantly decreased in the preterm group. The pattern of n-3 PUFA deficiency at birth and sustained for the first month of life would support the need of milk banking fortified with DHA and the use of DHA supplementation in breastfeeding mothers. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/281757https://dx.doi.org/urn:doi:10.3390/nu14234956reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2817572026-06-06T12:50:31Z
dc.title.none.fl_str_mv Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life
A Comparative Study with Infants at Term
title Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life
spellingShingle Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life
Castillo Salinas, Félix|||0000-0003-3155-6290
Docosahexaenoic acid
Arachidonic acid
Linoleic acid
Eicosapentaenoic acid
Lipid profile
Preterm infants
Erythrocyte membrane
title_short Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life
title_full Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life
title_fullStr Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life
title_full_unstemmed Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life
title_sort Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life
dc.creator.none.fl_str_mv Castillo Salinas, Félix|||0000-0003-3155-6290
Montaner Ramón, Alicia|||0000-0002-7327-0066
Castillo-Ferrer, Félix-Joel
Domingo-Carnice, Adrià
Cordobilla, Begoña|||0000-0002-0418-9387
Domingo, Joan Carles|||0000-0002-6356-0836
author Castillo Salinas, Félix|||0000-0003-3155-6290
author_facet Castillo Salinas, Félix|||0000-0003-3155-6290
Montaner Ramón, Alicia|||0000-0002-7327-0066
Castillo-Ferrer, Félix-Joel
Domingo-Carnice, Adrià
Cordobilla, Begoña|||0000-0002-0418-9387
Domingo, Joan Carles|||0000-0002-6356-0836
author_role author
author2 Montaner Ramón, Alicia|||0000-0002-7327-0066
Castillo-Ferrer, Félix-Joel
Domingo-Carnice, Adrià
Cordobilla, Begoña|||0000-0002-0418-9387
Domingo, Joan Carles|||0000-0002-6356-0836
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Docosahexaenoic acid
Arachidonic acid
Linoleic acid
Eicosapentaenoic acid
Lipid profile
Preterm infants
Erythrocyte membrane
topic Docosahexaenoic acid
Arachidonic acid
Linoleic acid
Eicosapentaenoic acid
Lipid profile
Preterm infants
Erythrocyte membrane
description An observational comparative study was designed to assess the fatty acids profile in erythrocyte membrane phospholipids of 30 preterm neonates (<32 weeks gestation) at birth and after 1 month of life versus a convenience sample of 10 infants born at term. The panel of fatty acids included the families and components of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and n-6 and n-3 polyunsaturated fatty acids (PUFAs) as well as enzyme activity indexes and fatty acids ratios. At birth, the comparison of fatty acid families between preterm and term neonates showed a significantly higher content of SFAs and n-6 PUFAs, and a significantly lower content of MUFAs and n-3 PUFAs in the preterm group. After 30 days of life, significantly higher levels of n-6 PUFAs and significantly lower levels of n-3 PUFAs among preterm neonates persisted. At 30 days of birth, n-6 PUFA/n-3 PUFA and arachidonic acid (ARA) ARA/DHA remained significantly elevated, and DHA sufficiency index significantly decreased in the preterm group. The pattern of n-3 PUFA deficiency at birth and sustained for the first month of life would support the need of milk banking fortified with DHA and the use of DHA supplementation in breastfeeding mothers.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/281757
https://dx.doi.org/urn:doi:10.3390/nu14234956
url https://ddd.uab.cat/record/281757
https://dx.doi.org/urn:doi:10.3390/nu14234956
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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