Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept

An increase in resistance to key antibiotics has made the need for novel treatments for the gastric colonization of Helicobacter pylori (H. pylori) a matter of the utmost urgency. Recent studies tackling this topic have focused either on the discovery of new compounds to ameliorate therapeutic regim...

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Autores: Grosso, Roberto, Benito Hernández, Elena María, Carbajo Gordillo, Ana Isabel, García Martín, María de Gracia, Pérez-Puyana, Víctor Manuel, Sánchez Cid, Pablo, Paz Báñez, María Violante de
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/143023
Acesso em linha:https://hdl.handle.net/11441/143023
https://doi.org/10.3390/ijms24032281
Access Level:acceso abierto
Palavra-chave:Amoxicillin
Bioorthogonal chemistry
Gastroretentive DDS
Guar gum
Helicobacter pylori
Mucoadhesive polymers
Semi-IPN
Super-porous hydrogels
Vonoprazan
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spelling Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of ConceptGrosso, RobertoBenito Hernández, Elena MaríaCarbajo Gordillo, Ana IsabelGarcía Martín, María de GraciaPérez-Puyana, Víctor ManuelSánchez Cid, PabloPaz Báñez, María Violante deAmoxicillinBioorthogonal chemistryGastroretentive DDSGuar gumHelicobacter pyloriMucoadhesive polymersSemi-IPNSuper-porous hydrogelsVonoprazanAn increase in resistance to key antibiotics has made the need for novel treatments for the gastric colonization of Helicobacter pylori (H. pylori) a matter of the utmost urgency. Recent studies tackling this topic have focused either on the discovery of new compounds to ameliorate therapeutic regimes (such as vonoprazan) or the synthesis of gastroretentive drug delivery systems (GRDDSs) to improve the pharmacokinetics of oral formulations. The use of semi-interpenetrating polymer networks (semi-IPNs) that can act as super-porous hydrogels for this purpose is proposed in the present work, specifically those displaying low ecological footprint, easy synthesis, self-floating properties, high encapsulation efficiency for drugs such as amoxicillin (AMOX), great mucoadhesiveness, and optimal mechanical strength when exposed to stomach-like fluids. To achieve such systems, biodegradable synthetic copolymers containing acid-labile monomers were prepared and interpenetrated with guar gum (GG) in a one-pot polymerization process based on thiol-ene click reactions. The resulting matrices were characterized by SEM, GPC, TGA, NMR, and rheology studies, and the acidic hydrolysis of the acid-sensitive polymers was also studied. Results confirm that some of the obtained matrices are expected to perform optimally as GRDDSs for the sustained release of active pharmaceutical ingredients at the gastrointestinal level, being a priori facilitated by its disaggregation. Therefore, the optimal performance of these systems is assessed by varying the molar ratio of the labile monomer in the matrices.Ministerio de Ciencia e Innovación PID2020-115916GB-I00Junta de Andalucía US-1380587Multidisciplinary Digital Publishing Institute (MDPI)Química Orgánica y FarmacéuticaIngeniería QuímicaMinisterio de Ciencia e Innovación (MICIN). EspañaJunta de Andalucía2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/143023https://doi.org/10.3390/ijms24032281reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Molecular Sciences, 24 (3), 2281.PID2020-115916GB-I00US-1380587https://doi.org/10.3390/ijms24032281info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1430232026-06-17T12:51:07Z
dc.title.none.fl_str_mv Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept
title Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept
spellingShingle Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept
Grosso, Roberto
Amoxicillin
Bioorthogonal chemistry
Gastroretentive DDS
Guar gum
Helicobacter pylori
Mucoadhesive polymers
Semi-IPN
Super-porous hydrogels
Vonoprazan
title_short Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept
title_full Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept
title_fullStr Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept
title_full_unstemmed Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept
title_sort Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept
dc.creator.none.fl_str_mv Grosso, Roberto
Benito Hernández, Elena María
Carbajo Gordillo, Ana Isabel
García Martín, María de Gracia
Pérez-Puyana, Víctor Manuel
Sánchez Cid, Pablo
Paz Báñez, María Violante de
author Grosso, Roberto
author_facet Grosso, Roberto
Benito Hernández, Elena María
Carbajo Gordillo, Ana Isabel
García Martín, María de Gracia
Pérez-Puyana, Víctor Manuel
Sánchez Cid, Pablo
Paz Báñez, María Violante de
author_role author
author2 Benito Hernández, Elena María
Carbajo Gordillo, Ana Isabel
García Martín, María de Gracia
Pérez-Puyana, Víctor Manuel
Sánchez Cid, Pablo
Paz Báñez, María Violante de
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Química Orgánica y Farmacéutica
Ingeniería Química
Ministerio de Ciencia e Innovación (MICIN). España
Junta de Andalucía
dc.subject.none.fl_str_mv Amoxicillin
Bioorthogonal chemistry
Gastroretentive DDS
Guar gum
Helicobacter pylori
Mucoadhesive polymers
Semi-IPN
Super-porous hydrogels
Vonoprazan
topic Amoxicillin
Bioorthogonal chemistry
Gastroretentive DDS
Guar gum
Helicobacter pylori
Mucoadhesive polymers
Semi-IPN
Super-porous hydrogels
Vonoprazan
description An increase in resistance to key antibiotics has made the need for novel treatments for the gastric colonization of Helicobacter pylori (H. pylori) a matter of the utmost urgency. Recent studies tackling this topic have focused either on the discovery of new compounds to ameliorate therapeutic regimes (such as vonoprazan) or the synthesis of gastroretentive drug delivery systems (GRDDSs) to improve the pharmacokinetics of oral formulations. The use of semi-interpenetrating polymer networks (semi-IPNs) that can act as super-porous hydrogels for this purpose is proposed in the present work, specifically those displaying low ecological footprint, easy synthesis, self-floating properties, high encapsulation efficiency for drugs such as amoxicillin (AMOX), great mucoadhesiveness, and optimal mechanical strength when exposed to stomach-like fluids. To achieve such systems, biodegradable synthetic copolymers containing acid-labile monomers were prepared and interpenetrated with guar gum (GG) in a one-pot polymerization process based on thiol-ene click reactions. The resulting matrices were characterized by SEM, GPC, TGA, NMR, and rheology studies, and the acidic hydrolysis of the acid-sensitive polymers was also studied. Results confirm that some of the obtained matrices are expected to perform optimally as GRDDSs for the sustained release of active pharmaceutical ingredients at the gastrointestinal level, being a priori facilitated by its disaggregation. Therefore, the optimal performance of these systems is assessed by varying the molar ratio of the labile monomer in the matrices.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/143023
https://doi.org/10.3390/ijms24032281
url https://hdl.handle.net/11441/143023
https://doi.org/10.3390/ijms24032281
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences, 24 (3), 2281.
PID2020-115916GB-I00
US-1380587
https://doi.org/10.3390/ijms24032281
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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