Associations of phosphorylated tau pathology with whole-hemisphere ex-vivo morphometry in 7 tesla MRI

IntroductionNeurodegenerative disorders are associated with different pathologies that often co-occur but cannot be measured specifically with in vivo methods.MethodsThirty-three brain hemispheres from donors with an Alzheimer's disease (AD) spectrum diagnosis underwent T2-weighted magnetic res...

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Authors: Sadaghiani, Shokufeh, Trotman, Winifred, Lim, Sydney A., Chung, Eunice, Ittyerah, Ranjit, Ravikumar, Sadhana, Artacho Pérula, Emilio, Arroyo Jiménez, María del Mar, Marcos Rabal, María del Pilar, Cebada Sánchez, Sandra, Rosa Prieto, Carlos de la, Córcoles Parada, Marta, Insausti Serrano, Ricardo, Wisse, Laura E. M., Irwin, David J., Wolk, David A., Yushkevich, Paul A.
Format: article
Publication Date:2022
Country:España
Institution:Universidad de Castilla-La Mancha
Repository:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/34553
Online Access:https://hdl.handle.net/10578/34553
Access Level:Open access
Keyword:Alzheimer’s disease
Biomarkers
Cortical thickness
Ex vivo MRI
Neurodegeneration
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Summary:IntroductionNeurodegenerative disorders are associated with different pathologies that often co-occur but cannot be measured specifically with in vivo methods.MethodsThirty-three brain hemispheres from donors with an Alzheimer's disease (AD) spectrum diagnosis underwent T2-weighted magnetic resonance imaging (MRI). Gray matter thickness was paired with histopathology from the closest anatomic region in the contralateral hemisphere.ResultsPartial Spearman correlation of phosphorylated tau and cortical thickness with TAR DNA-binding protein 43 (TDP-43) and a-synuclein scores, age, sex, and postmortem interval as covariates showed significant relationships in entorhinal and primary visual cortices, temporal pole, and insular and posterior cingulate gyri. Linear models including Braak stages, TDP-43 and a-synuclein scores, age, sex, and postmortem interval showed significant correlation between Braak stage and thickness in the parahippocampal gyrus, entorhinal cortex, and Broadman area 35.ConclusionWe demonstrated an association of measures of AD pathology with tissue loss in several AD regions despite a limited range of pathology in these cases.

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