Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition

Introduction: Maternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal disorders. This study focused on the immunomodula...

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Autores: Sáez Fuertes, Laura, Kapravelou, Garyfallia, Grases Pintó, Blanca, Massot Cladera, Malen, Bernabeu, Manuel, Knipping, Karen, Garssen, Johan, Bourdet-Sicard, Raphaëlle, Castell, Margarida, Rodríguez-Lagunas, María José, Collado, María Carmen, Pérez-Cano, Francisco José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/364098
Acceso en línea:http://hdl.handle.net/10261/364098
https://api.elsevier.com/content/abstract/scopus_id/85197504261
Access Level:acceso abierto
Palabra clave:Bifidobacterium breve M-16V
Breastfeeding
Long chain fructo-oligosachairdes (lcFOS)
Pregnancy
Short chain galacto-oligosaccharides (scGOS)
immune system
human milk
probiotics
pregnancy
breastfeeding
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repository_id_str
spelling Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk compositionSáez Fuertes, LauraKapravelou, GaryfalliaGrases Pintó, BlancaMassot Cladera, MalenBernabeu, ManuelKnipping, KarenGarssen, JohanBourdet-Sicard, RaphaëlleCastell, MargaridaRodríguez-Lagunas, María JoséCollado, María CarmenPérez-Cano, Francisco JoséBifidobacterium breve M-16VBreastfeedingLong chain fructo-oligosachairdes (lcFOS)PregnancyShort chain galacto-oligosaccharides (scGOS)immune systemhuman milkprobioticspregnancybreastfeedingIntroduction: Maternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal disorders. This study focused on the immunomodulatory effects of B. breve M-16V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosachairdes (lcFOS), including systemic and mucosal compartments and milk composition. Methods: Lewis rats were orally administered with the synbiotic or vehicle during pregnancy (21 days) and lactation (21 days). At the weaning day, small intestine (SI), mammary gland (MG), adipose tissue, milk, mesenteric lymph nodes (MLN), salivary gland (SG), feces and cecal content were collected from the mothers. Results: The immunoglobulinome profile showed increased IgG2c in plasma and milk, as well as elevated sIgA in feces at weaning. The supplementation improved lipid metabolism through enhanced brown adipose tissue activity and reinforced the intestinal barrier by increasing the expression of Muc3, Cldn4, and Ocln. The higher production of short chain fatty acids in the cecum and increased Bifidobacterium counts suggest a potential positive impact on the gastrointestinal tract. Discussion: These findings indicate that maternal synbiotic supplementation during gestation and lactation improves their immunological status and improved milk composition.The research described in this paper was supported by La Marató-TV3 (DIM-2-ELI, ref. 2018–27/30–31). LS-F holds a fellowship from the Generalitat de Catalunya, FI-SDUR (2023 FISDU 00035). The INSA-UB acknowledge the Maria de Maeztu Unit of Excellence (Grant CEX2021–001234-M) funded by MICIN/AEI/FEDER, UE. The IATA-CSIC authors also acknowledge the Spanish government MCIN/AEI to the Center of Excellence Accreditation Severo Ochoa (CEX2021–001189-S/MCIN/AEI/10.13039/501100011033).With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2021-001189-S and CEX2021-001234-M)Peer reviewedFrontiers MediaFundació La Marató de TV3Generalitat de CatalunyaEuropean CommissionMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Collado, María Carmen [0000-0002-6204-4864]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/364098https://api.elsevier.com/content/abstract/scopus_id/85197504261reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX 2021-001189-Sinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001234-MFrontiers in ImmunologyThe underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.3389/fimmu.2024.1418594https://doi.org/10.3389/fimmu.2024.1418594Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3640982026-05-22T06:33:51Z
dc.title.none.fl_str_mv Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
title Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
spellingShingle Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
Sáez Fuertes, Laura
Bifidobacterium breve M-16V
Breastfeeding
Long chain fructo-oligosachairdes (lcFOS)
Pregnancy
Short chain galacto-oligosaccharides (scGOS)
immune system
human milk
probiotics
pregnancy
breastfeeding
title_short Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
title_full Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
title_fullStr Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
title_full_unstemmed Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
title_sort Impact of maternal Bifidobacterium breve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition
dc.creator.none.fl_str_mv Sáez Fuertes, Laura
Kapravelou, Garyfallia
Grases Pintó, Blanca
Massot Cladera, Malen
Bernabeu, Manuel
Knipping, Karen
Garssen, Johan
Bourdet-Sicard, Raphaëlle
Castell, Margarida
Rodríguez-Lagunas, María José
Collado, María Carmen
Pérez-Cano, Francisco José
author Sáez Fuertes, Laura
author_facet Sáez Fuertes, Laura
Kapravelou, Garyfallia
Grases Pintó, Blanca
Massot Cladera, Malen
Bernabeu, Manuel
Knipping, Karen
Garssen, Johan
Bourdet-Sicard, Raphaëlle
Castell, Margarida
Rodríguez-Lagunas, María José
Collado, María Carmen
Pérez-Cano, Francisco José
author_role author
author2 Kapravelou, Garyfallia
Grases Pintó, Blanca
Massot Cladera, Malen
Bernabeu, Manuel
Knipping, Karen
Garssen, Johan
Bourdet-Sicard, Raphaëlle
Castell, Margarida
Rodríguez-Lagunas, María José
Collado, María Carmen
Pérez-Cano, Francisco José
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundació La Marató de TV3
Generalitat de Catalunya
European Commission
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Collado, María Carmen [0000-0002-6204-4864]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bifidobacterium breve M-16V
Breastfeeding
Long chain fructo-oligosachairdes (lcFOS)
Pregnancy
Short chain galacto-oligosaccharides (scGOS)
immune system
human milk
probiotics
pregnancy
breastfeeding
topic Bifidobacterium breve M-16V
Breastfeeding
Long chain fructo-oligosachairdes (lcFOS)
Pregnancy
Short chain galacto-oligosaccharides (scGOS)
immune system
human milk
probiotics
pregnancy
breastfeeding
description Introduction: Maternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal disorders. This study focused on the immunomodulatory effects of B. breve M-16V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosachairdes (lcFOS), including systemic and mucosal compartments and milk composition. Methods: Lewis rats were orally administered with the synbiotic or vehicle during pregnancy (21 days) and lactation (21 days). At the weaning day, small intestine (SI), mammary gland (MG), adipose tissue, milk, mesenteric lymph nodes (MLN), salivary gland (SG), feces and cecal content were collected from the mothers. Results: The immunoglobulinome profile showed increased IgG2c in plasma and milk, as well as elevated sIgA in feces at weaning. The supplementation improved lipid metabolism through enhanced brown adipose tissue activity and reinforced the intestinal barrier by increasing the expression of Muc3, Cldn4, and Ocln. The higher production of short chain fatty acids in the cecum and increased Bifidobacterium counts suggest a potential positive impact on the gastrointestinal tract. Discussion: These findings indicate that maternal synbiotic supplementation during gestation and lactation improves their immunological status and improved milk composition.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/364098
https://api.elsevier.com/content/abstract/scopus_id/85197504261
url http://hdl.handle.net/10261/364098
https://api.elsevier.com/content/abstract/scopus_id/85197504261
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX 2021-001189-S
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001234-M
Frontiers in Immunology
The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.3389/fimmu.2024.1418594
https://doi.org/10.3389/fimmu.2024.1418594
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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