Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity

Mesoporous bioactive glass nanoparticles (MBGNs) have gained considerable attention as multifunctional platforms for simultaneously releasing ions and phytotherapeutic compounds. Thus, in the first part of this study, MBGNs based on the 53SiO₂–4P₂O₅–20CaO–23Na₂O (wt %) (S53P4) composition were synth...

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Detalles Bibliográficos
Autores: Damian-Buda, Andrada-Ioana, Nawaz, Qaisar, Unalan, Irem, Beltrán, Ana M., Boccaccini, Aldo R.
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2023
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/148609
Acceso en línea:https://hdl.handle.net/11441/148609
https://doi.org/10.1016/j.ceramint.2023.06.250
Access Level:acceso abierto
Palabra clave:Mesoporous bioactive glass nanoparticles
Control release
Gallic acid
Antibacterial effect
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spelling Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activityDamian-Buda, Andrada-IoanaNawaz, QaisarUnalan, IremBeltrán, Ana M.Boccaccini, Aldo R.Mesoporous bioactive glass nanoparticlesControl releaseGallic acidAntibacterial effectMesoporous bioactive glass nanoparticles (MBGNs) have gained considerable attention as multifunctional platforms for simultaneously releasing ions and phytotherapeutic compounds. Thus, in the first part of this study, MBGNs based on the 53SiO₂–4P₂O₅–20CaO–23Na₂O (wt %) (S53P4) composition were synthesized by a microemulsion assisted sol-gel method. More precisely, P₂O₅ was substituted with B₂O₃ and Na₂O with MgO and/or ZnO. For B containing MBGNs all ions were successfully incorporated into the borosilicate structure without inducing crystallisation. In contrast, for S53P4 a poorly crystalline hydroxyapatite phase was identified. All MBGNs had a typical spherical shape with an internal radial network of mesopores. Additionally, for S53P4 a second fraction of particles with a smaller size and compact core was observed. Secondly, the feasibility of MBGNs as nanocarriers for gallic acid (GA) was evaluated. All drug-loaded samples showed a similar in vitro release profile which can be divided into three main phases: burst release, slow release and sustained release. Among the different compositions, S53P4 exhibited the highest cumulative release, whereas B and Mg containing particles exhibited the opposite. The presence of Zn in the MBGN compositions improved their antibacterial effect against both E. coli and S. aureus. Moreover, it was shown that depending on the MBGNs’ composition, the antibacterial activity of GA loaded MBGNs can be enhanced. Thus, the results proved that MBGNs can be used as controlled drug delivery system and, by tailoring the composition, a synergistic antibacterial effect can be achieved, considering that GA and biologically active ions are simultaneously released.Universidad de Sevilla (CITUS)ElsevierIngeniería y Ciencia de los Materiales y del TransporteTEP123: Metalurgia e Ingeniería de los Materiales2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/148609https://doi.org/10.1016/j.ceramint.2023.06.250reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésCeramics International, 49 (18), 29923-29932.https://www.sciencedirect.com/science/article/pii/S0272884223018370info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1486092026-06-17T12:51:07Z
dc.title.none.fl_str_mv Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity
title Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity
spellingShingle Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity
Damian-Buda, Andrada-Ioana
Mesoporous bioactive glass nanoparticles
Control release
Gallic acid
Antibacterial effect
title_short Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity
title_full Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity
title_fullStr Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity
title_full_unstemmed Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity
title_sort Quaternary and pentanar mesoporous bioactive glass nanoparticles as novel nanocarriers for gallic acid: Characterisation, drug release and antibacterial activity
dc.creator.none.fl_str_mv Damian-Buda, Andrada-Ioana
Nawaz, Qaisar
Unalan, Irem
Beltrán, Ana M.
Boccaccini, Aldo R.
author Damian-Buda, Andrada-Ioana
author_facet Damian-Buda, Andrada-Ioana
Nawaz, Qaisar
Unalan, Irem
Beltrán, Ana M.
Boccaccini, Aldo R.
author_role author
author2 Nawaz, Qaisar
Unalan, Irem
Beltrán, Ana M.
Boccaccini, Aldo R.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ingeniería y Ciencia de los Materiales y del Transporte
TEP123: Metalurgia e Ingeniería de los Materiales
dc.subject.none.fl_str_mv Mesoporous bioactive glass nanoparticles
Control release
Gallic acid
Antibacterial effect
topic Mesoporous bioactive glass nanoparticles
Control release
Gallic acid
Antibacterial effect
description Mesoporous bioactive glass nanoparticles (MBGNs) have gained considerable attention as multifunctional platforms for simultaneously releasing ions and phytotherapeutic compounds. Thus, in the first part of this study, MBGNs based on the 53SiO₂–4P₂O₅–20CaO–23Na₂O (wt %) (S53P4) composition were synthesized by a microemulsion assisted sol-gel method. More precisely, P₂O₅ was substituted with B₂O₃ and Na₂O with MgO and/or ZnO. For B containing MBGNs all ions were successfully incorporated into the borosilicate structure without inducing crystallisation. In contrast, for S53P4 a poorly crystalline hydroxyapatite phase was identified. All MBGNs had a typical spherical shape with an internal radial network of mesopores. Additionally, for S53P4 a second fraction of particles with a smaller size and compact core was observed. Secondly, the feasibility of MBGNs as nanocarriers for gallic acid (GA) was evaluated. All drug-loaded samples showed a similar in vitro release profile which can be divided into three main phases: burst release, slow release and sustained release. Among the different compositions, S53P4 exhibited the highest cumulative release, whereas B and Mg containing particles exhibited the opposite. The presence of Zn in the MBGN compositions improved their antibacterial effect against both E. coli and S. aureus. Moreover, it was shown that depending on the MBGNs’ composition, the antibacterial activity of GA loaded MBGNs can be enhanced. Thus, the results proved that MBGNs can be used as controlled drug delivery system and, by tailoring the composition, a synergistic antibacterial effect can be achieved, considering that GA and biologically active ions are simultaneously released.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/148609
https://doi.org/10.1016/j.ceramint.2023.06.250
url https://hdl.handle.net/11441/148609
https://doi.org/10.1016/j.ceramint.2023.06.250
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Ceramics International, 49 (18), 29923-29932.
https://www.sciencedirect.com/science/article/pii/S0272884223018370
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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