In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients

Background and Aims: Influenza mortality rates varying across different populations. This study aims to assess influenza lethality in hospitalized adults (>= 15 years) and identify key risk factors according to age. Methods: We designed a retrospective study at Dr. Balmis General University Hospi...

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Autores: Ramos-Rincon, JM, Pinargote-Celorio, H, Sanchez-Martinez, R, Rodriguez-Diaz, JC, Otero, S, Valero-Sempere, F, Torrus, D, Valero-Novella, B, Riera, G, Boix, V, Merino, E
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p11162
Acesso em linha:https://isabial.portalinvestigacion.com/publicaciones11162
https://doi.org/10.1002/hsr2.70458
Access Level:acceso abierto
Palavra-chave:aged
influenza
mortality
over 80 and older
respiratory insufficiency
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spelling In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older PatientsRamos-Rincon, JMPinargote-Celorio, HSanchez-Martinez, RRodriguez-Diaz, JCOtero, SValero-Sempere, FTorrus, DValero-Novella, BRiera, GBoix, VMerino, Eagedinfluenzamortalityover 80 and olderrespiratory insufficiencyBackground and Aims: Influenza mortality rates varying across different populations. This study aims to assess influenza lethality in hospitalized adults (>= 15 years) and identify key risk factors according to age. Methods: We designed a retrospective study at Dr. Balmis General University Hospital (Alicante, Spain), including patients hospitalized for influenza from 2016 to 2022. In-hospital death was expressed as the case fatality rate (CFR). Variables yielding a p value under 0.1 on univariable analysis were included in the multivariable logistic regression model to identify risk factors for lethality. Results: Of 1613 patients admitted for influenza (incidence 86 per 10,000 admissions), 96 died (CFR 5.95%). Lethality increased with age, reaching 8.4% in patients aged 80-89 years and 19.5% in those over 90. In all of the cohort, risk factors were age, dementia, respiratory failure, influenza pneumonia, and sepsis, while treatment with oseltamivir acted as a protective factor. In patients < 80 years of age, risk factors were neoplasia, respiratory failure, and influenza pneumonia, whereas oseltamivir treatment was a protective factor. In patients 80 years (n = 554; 34.3%), the risk of mortality increased with age, dementia, respiratory failure, noninfluenza pneumonia, and sepsis. Conclusion: Influenza deaths increase with age; this relationship is accentuated in people aged 80 or older. Respiratory failure was the main risk factor in all patients hospitalized for influenza. Treatment with oseltamivir protected patients (especially those < 80 years) against deaths. Patients < 80 years-old carried a higher risk of death if they had a neoplasia, whereas in >= 80 patients, the risk was associated with dementia and noninfluenza pneumonia.WILEY2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones11162https://doi.org/10.1002/hsr2.70458Health Science ReportsISSN: 23988835reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p111622026-06-12T10:20:37Z
dc.title.none.fl_str_mv In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients
title In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients
spellingShingle In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients
Ramos-Rincon, JM
aged
influenza
mortality
over 80 and older
respiratory insufficiency
title_short In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients
title_full In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients
title_fullStr In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients
title_full_unstemmed In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients
title_sort In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients
dc.creator.none.fl_str_mv Ramos-Rincon, JM
Pinargote-Celorio, H
Sanchez-Martinez, R
Rodriguez-Diaz, JC
Otero, S
Valero-Sempere, F
Torrus, D
Valero-Novella, B
Riera, G
Boix, V
Merino, E
author Ramos-Rincon, JM
author_facet Ramos-Rincon, JM
Pinargote-Celorio, H
Sanchez-Martinez, R
Rodriguez-Diaz, JC
Otero, S
Valero-Sempere, F
Torrus, D
Valero-Novella, B
Riera, G
Boix, V
Merino, E
author_role author
author2 Pinargote-Celorio, H
Sanchez-Martinez, R
Rodriguez-Diaz, JC
Otero, S
Valero-Sempere, F
Torrus, D
Valero-Novella, B
Riera, G
Boix, V
Merino, E
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv aged
influenza
mortality
over 80 and older
respiratory insufficiency
topic aged
influenza
mortality
over 80 and older
respiratory insufficiency
description Background and Aims: Influenza mortality rates varying across different populations. This study aims to assess influenza lethality in hospitalized adults (>= 15 years) and identify key risk factors according to age. Methods: We designed a retrospective study at Dr. Balmis General University Hospital (Alicante, Spain), including patients hospitalized for influenza from 2016 to 2022. In-hospital death was expressed as the case fatality rate (CFR). Variables yielding a p value under 0.1 on univariable analysis were included in the multivariable logistic regression model to identify risk factors for lethality. Results: Of 1613 patients admitted for influenza (incidence 86 per 10,000 admissions), 96 died (CFR 5.95%). Lethality increased with age, reaching 8.4% in patients aged 80-89 years and 19.5% in those over 90. In all of the cohort, risk factors were age, dementia, respiratory failure, influenza pneumonia, and sepsis, while treatment with oseltamivir acted as a protective factor. In patients < 80 years of age, risk factors were neoplasia, respiratory failure, and influenza pneumonia, whereas oseltamivir treatment was a protective factor. In patients 80 years (n = 554; 34.3%), the risk of mortality increased with age, dementia, respiratory failure, noninfluenza pneumonia, and sepsis. Conclusion: Influenza deaths increase with age; this relationship is accentuated in people aged 80 or older. Respiratory failure was the main risk factor in all patients hospitalized for influenza. Treatment with oseltamivir protected patients (especially those < 80 years) against deaths. Patients < 80 years-old carried a higher risk of death if they had a neoplasia, whereas in >= 80 patients, the risk was associated with dementia and noninfluenza pneumonia.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones11162
https://doi.org/10.1002/hsr2.70458
url https://isabial.portalinvestigacion.com/publicaciones11162
https://doi.org/10.1002/hsr2.70458
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv Health Science Reports
ISSN: 23988835
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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