Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease

9 pages, 1 figure.-- PMID: 19102766 [PubMed].-- PMCID: PMC2635381.

Detalles Bibliográficos
Autores: Collado, María Carmen, Donat, Ester, Ribes-Koninckx, Carmen, Calabuig, Miguel, Sanz Herranz, Yolanda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/10574
Acceso en línea:http://hdl.handle.net/10261/10574
Access Level:acceso abierto
Palabra clave:Gut bifidobacteria
Faecal samples
Duodenal biopsy specimens
Coeliac disease
Children
B. longum
B. catenulatum
B. dentium
Adjuvant dietary therapies
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spelling Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac diseaseCollado, María CarmenDonat, EsterRibes-Koninckx, CarmenCalabuig, MiguelSanz Herranz, YolandaGut bifidobacteriaFaecal samplesDuodenal biopsy specimensCoeliac diseaseChildrenB. longumB. catenulatumB. dentiumAdjuvant dietary therapies9 pages, 1 figure.-- PMID: 19102766 [PubMed].-- PMCID: PMC2635381.[Background] Gut bifidobacteria are believed to influence immune-related diseases. The objective of this study was to assess the possible relationships between the gut bifidobacteria composition and coeliac disease (CD) in children.A total of 48 faecal samples (30 and 18 samples from active and no active CD patients, respectively) and 33 duodenal biopsy specimens of CD patients (25 and 8 samples from active and non-active CD patients, respectively) were analysed. Samples (30 faecal samples and 8 biopsies) from a control age-matched group of children were also included for comparative purposes. Gut Bifidobacterium genus and species were analyzed by real-time PCR.[Results] Active and non-active CD patients showed lower numbers of total Bifidobacterium and B. longum species in faeces and duodenal biopsies than controls, and these differences were particularly remarkable between active CD patients and controls. B. catenulatum prevalence was higher in biopsies of controls than in those of active and non-active CD patients, whereas B. dentium prevalence was higher in faeces of non-active CD patients than in controls. Correlations between levels of Bifidobacterium and B. longum species in faecal and biopsy samples were detected in both CD patients and controls.[Conclusion] Reductions in total Bifidobacterium and B. longum populations were associated with both active and non-active CD when compared to controls. These bacterial groups could constitute novel targets for adjuvant dietary therapies although the confirmation of this hypothesis would require further investigations.This work was supported by grant AGL2005-05788-C02-01 and Consolider Fun-C-Food CSD2007-00063 from the Spanish Ministry of Science and Innovation. The I3P-CSIC Postdoctoral Contract from the European Social Fund to MC. Collado is fully acknowledged.Peer reviewedBioMed Central200920092008info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersion289394 bytesapplication/pdfhttp://hdl.handle.net/10261/10574reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1186/1471-2180-8-232info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/105742026-05-22T06:33:51Z
dc.title.none.fl_str_mv Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease
title Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease
spellingShingle Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease
Collado, María Carmen
Gut bifidobacteria
Faecal samples
Duodenal biopsy specimens
Coeliac disease
Children
B. longum
B. catenulatum
B. dentium
Adjuvant dietary therapies
title_short Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease
title_full Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease
title_fullStr Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease
title_full_unstemmed Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease
title_sort Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease
dc.creator.none.fl_str_mv Collado, María Carmen
Donat, Ester
Ribes-Koninckx, Carmen
Calabuig, Miguel
Sanz Herranz, Yolanda
author Collado, María Carmen
author_facet Collado, María Carmen
Donat, Ester
Ribes-Koninckx, Carmen
Calabuig, Miguel
Sanz Herranz, Yolanda
author_role author
author2 Donat, Ester
Ribes-Koninckx, Carmen
Calabuig, Miguel
Sanz Herranz, Yolanda
author2_role author
author
author
author
dc.subject.none.fl_str_mv Gut bifidobacteria
Faecal samples
Duodenal biopsy specimens
Coeliac disease
Children
B. longum
B. catenulatum
B. dentium
Adjuvant dietary therapies
topic Gut bifidobacteria
Faecal samples
Duodenal biopsy specimens
Coeliac disease
Children
B. longum
B. catenulatum
B. dentium
Adjuvant dietary therapies
description 9 pages, 1 figure.-- PMID: 19102766 [PubMed].-- PMCID: PMC2635381.
publishDate 2008
dc.date.none.fl_str_mv 2008
2009
2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/10574
url http://hdl.handle.net/10261/10574
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1186/1471-2180-8-232
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 289394 bytes
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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